Title:
ANTI-HUMAN CLAUDIN 18.2 ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/058000
Kind Code:
A1
Abstract:
The present invention provides an antibody that binds to human Claudin 18.2 or a fragment thereof, as well as encoded nucleic acids and the like thereof. The anti-human Claudin 18.2 antibody of the present invention has strong affinity to an antigen Claudin 18.2 and significant complement-dependent cytotoxicity (CDC) activity and antibody-dependent cytotoxicity (ADCC) activity to target expression cells, and exhibits high specificity to human CLDN 18.2.
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Inventors:
LIN JIAN (CN)
DENG XIAOFANG (CN)
GAO PAN (CN)
XU XIAOHONG (CN)
WANG LICHUN (CN)
REN HONGYUAN (CN)
BI JIANJUN (CN)
WANG JIN (CN)
DENG XIAOFANG (CN)
GAO PAN (CN)
XU XIAOHONG (CN)
WANG LICHUN (CN)
REN HONGYUAN (CN)
BI JIANJUN (CN)
WANG JIN (CN)
Application Number:
PCT/CN2020/118424
Publication Date:
April 01, 2021
Filing Date:
September 28, 2020
Export Citation:
Assignee:
MABWELL SHANGHAI BIOSCIENCE CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/63; G01N33/574
Domestic Patent References:
| WO2018006882A1 | 2018-01-11 |
Foreign References:
| CN107219351A | 2017-09-29 | |||
| CN108047331A | 2018-05-18 | |||
| CN108047331A | 2018-05-18 | |||
| CN109762067A | 2019-05-17 | |||
| CN109762067A | 2019-05-17 | |||
| CN201910929614A | 2019-09-29 |
Other References:
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
"Fundamental Immunology", 1989, RAVEN PRESS
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
See also references of EP 4063386A4
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
"Fundamental Immunology", 1989, RAVEN PRESS
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
See also references of EP 4063386A4
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
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