Title:
ANTI-HUMAN IL-2 MONOCLONAL ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/077773
Kind Code:
A1
Abstract:
Provided are an anti-human IL-2 monoclonal antibody, an antibody complex and use thereof. Once the anti-human IL-2 monoclonal antibody binds to IL2, binding of IL2 to IL2Rβ/γ (CD122/132) is maintained but binding of IL-2 to IL-2Rα (CD25) is blocked, thus effectively inhibiting growth of transplanted tumors in mice. Further provided is an anti-human IL-2 monoclonal antibody having an Fc constant region mutation, which can reduce the side effects of the antibody and improve drug safety.
Inventors:
LOU JING (CN)
CHEN JIANHE (CN)
SU DONGMEI (CN)
JIN ZHENG (CN)
LV YUNYING (CN)
ZHANG RUOLAN (CN)
PEI RUOCHEN (CN)
OU YANMEI (CN)
QU XIAO (CN)
XIE XIE (CN)
ZHANG JING (CN)
ZENG LIN (CN)
CHEN JIANHE (CN)
SU DONGMEI (CN)
JIN ZHENG (CN)
LV YUNYING (CN)
ZHANG RUOLAN (CN)
PEI RUOCHEN (CN)
OU YANMEI (CN)
QU XIAO (CN)
XIE XIE (CN)
ZHANG JING (CN)
ZENG LIN (CN)
Application Number:
PCT/CN2022/141438
Publication Date:
April 18, 2024
Filing Date:
December 23, 2022
Export Citation:
Assignee:
SHENZHEN BAISHITONG TECH DEVELOPMENT COMPANY LIMITED (CN)
International Classes:
C07K16/24; A61K39/395; A61P35/00; C12N15/13
Attorney, Agent or Firm:
GUANGDONG JINSUI INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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