Title:
ANTI-HUMAN LAG-3 MONOCLONAL ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/192493
Kind Code:
A1
Abstract:
Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.
Inventors:
SONG NINGNING (CN)
DUAN QING (CN)
SHAO XIAOHUI (CN)
WANG PENG (CN)
BIAN XIAOJIAO (CN)
WANG QIAN (CN)
WEI PEIPEI (CN)
HUANG YAJUN (CN)
WU JIAN (CN)
WANG MEILING (CN)
WANG YUANDONG (CN)
XU LINA (CN)
YANG TATCHI TEDDY (CN)
LIU LILE (CN)
DUAN QING (CN)
SHAO XIAOHUI (CN)
WANG PENG (CN)
BIAN XIAOJIAO (CN)
WANG QIAN (CN)
WEI PEIPEI (CN)
HUANG YAJUN (CN)
WU JIAN (CN)
WANG MEILING (CN)
WANG YUANDONG (CN)
XU LINA (CN)
YANG TATCHI TEDDY (CN)
LIU LILE (CN)
Application Number:
PCT/CN2019/081063
Publication Date:
October 10, 2019
Filing Date:
April 02, 2019
Export Citation:
Assignee:
SHANGHAI PHARMAEXPLORER CO LTD (CN)
PHARMAEXPLORER LTD (VG)
PHARMAEXPLORER LTD (VG)
International Classes:
A61K39/395; C07K16/18; A61P35/00; C07K1/00; C12N15/13; C12N15/63
Domestic Patent References:
| WO2017149143A1 | 2017-09-08 | |||
| WO2017037203A1 | 2017-03-09 |
Foreign References:
| CN107474137A | 2017-12-15 | |||
| US4816567A | 1989-03-28 | |||
| US4816397A | 1989-03-28 | |||
| US5585089A | 1996-12-17 | |||
| CN102176921A | 2011-09-07 |
Other References:
WORKMAN ET AL., IMMUNOL, vol. 174, 2005, pages 688 - 695
KABAT ET AL., NIH PUBL. NO. 91-3242, 1991, pages 647 - 669
CARILLO, H.LIPMAN, D., SIAM J. APPLIED MATH., vol. 48, 1988, pages 1073
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", 1987, ACADEMIC PRESS
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
SAMBROOK. J ET AL.: "Guide to Molecular Cloning Laboratory", 2002, SCIENCE PRESS
SAMBROOK, J.FRITSCH, E.F.MANIATIS T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
METHODS IN ENZYMOLOGY, vol. 220
DAVID H ET AL., METHODS MOL BIOL, vol. 960, 2013, pages 297 - 307
See also references of EP 3778632A4
KABAT ET AL., NIH PUBL. NO. 91-3242, 1991, pages 647 - 669
CARILLO, H.LIPMAN, D., SIAM J. APPLIED MATH., vol. 48, 1988, pages 1073
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", 1987, ACADEMIC PRESS
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
SAMBROOK. J ET AL.: "Guide to Molecular Cloning Laboratory", 2002, SCIENCE PRESS
SAMBROOK, J.FRITSCH, E.F.MANIATIS T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
METHODS IN ENZYMOLOGY, vol. 220
DAVID H ET AL., METHODS MOL BIOL, vol. 960, 2013, pages 297 - 307
See also references of EP 3778632A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: