Title:
ANTI-IL-17 APTAMER HAVING IMPROVED RETENTION IN BLOOD
Document Type and Number:
WIPO Patent Application WO/2017/094897
Kind Code:
A1
Abstract:
The present invention provides an anti-IL-17 aptamer having improved in-vivo stability, said aptamer comprising a compound represented by formula (I) (wherein the symbols are as defined in the description) or a pharmaceutically acceptable salt thereof, and a solvate or hydrate.
Inventors:
HARUTA KAZUHIKO (JP)
YAMAZAKI HIROAKI (JP)
YAMAZAKI HIROAKI (JP)
Application Number:
PCT/JP2016/085948
Publication Date:
June 08, 2017
Filing Date:
December 02, 2016
Export Citation:
Assignee:
ZENYAKU KOGYO CO LTD (JP)
International Classes:
C12N15/115; A61K31/7088; A61K48/00; A61P29/00; A61P31/00; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| WO2014148638A1 | 2014-09-25 | |||
| WO2008048079A1 | 2008-04-24 | |||
| WO2014148638A1 | 2014-09-25 | |||
| WO2006029258A2 | 2006-03-16 | |||
| WO2008048079A1 | 2008-04-24 |
Foreign References:
| JP2013502218A | 2013-01-24 | |||
| JP2006516288A | 2006-06-29 | |||
| US20030114647A1 | 2003-06-19 | |||
| JP2009517414A | 2009-04-30 | |||
| US5660985A | 1997-08-26 | |||
| US5756703A | ||||
| JP2010512421A | 2010-04-22 | |||
| JP2006513244A | 2006-04-20 |
Other References:
HARUTA, KAZUHIKO ET AL.: "A Novel PEGylation Method for Improving the Pharmacokinetic Properties of Anti-Interleukin-17A RNA Aptamers", NUCLEIC ACID THER., vol. 27, no. 1, 9 November 2016 (2016-11-09), pages 36 - 44, XP055496581, Retrieved from the Internet
SHINSUKE HIRAMOTO ET AL.: "Improvements of pharmacokinetic properties of anti-Interleukin- 17A aptamer by a novel PEGylation method", THE 39TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ONLINE SUMMARY, 16 November 2016 (2016-11-16), XP9510742
BIOCHEMICAL PHARMACOLOGY, vol. 77, 2009, pages 878 - 887
ARTHRITIS RES THER, vol. 12, 2010, pages 92
SPROAT ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 7059 - 7071
CHEMISTRY A EUROPEAN JOURNAL, vol. 20, 2014, pages 12165 - 12171
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 18, 2010, pages 8277 - 8282
JUDITH M. HEALY ET AL., PHARMACEUTICAL RESEARCH, vol. 21, no. 12, December 2004 (2004-12-01), pages 2234 - 2246
S TOYAMA ET AL., ARTHRITIS RES THER, vol. 12, 2010, pages R92
SHINSUKE HIRAMOTO ET AL.: "Improvements of pharmacokinetic properties of anti-Interleukin- 17A aptamer by a novel PEGylation method", THE 39TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ONLINE SUMMARY, 16 November 2016 (2016-11-16), XP9510742
BIOCHEMICAL PHARMACOLOGY, vol. 77, 2009, pages 878 - 887
ARTHRITIS RES THER, vol. 12, 2010, pages 92
SPROAT ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 7059 - 7071
CHEMISTRY A EUROPEAN JOURNAL, vol. 20, 2014, pages 12165 - 12171
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 18, 2010, pages 8277 - 8282
JUDITH M. HEALY ET AL., PHARMACEUTICAL RESEARCH, vol. 21, no. 12, December 2004 (2004-12-01), pages 2234 - 2246
S TOYAMA ET AL., ARTHRITIS RES THER, vol. 12, 2010, pages R92
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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