Title:
ANTI-INFLAMMATORY AGENT CONTAINING CITRULLUS-DERIVED COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/062966
Kind Code:
A1
Abstract:
The present invention provides an anti-inflammatory agent containing a compound having an anti-inflammatory effect and contained in juvenile citrullus. The anti-inflammatory agent comprises a compound represented by formula (1) or formula (2) as an active ingredient.
Inventors:
HASHIZUME TOSHIHARU (JP)
ITOH TOMOHIRO (JP)
ITOH TOMOHIRO (JP)
Application Number:
PCT/JP2023/033073
Publication Date:
March 28, 2024
Filing Date:
September 11, 2023
Export Citation:
Assignee:
HAGIHARA FARM PRODUCTION INST CO LTD (JP)
UNIV MIE (JP)
UNIV MIE (JP)
International Classes:
A61K31/7034; A23L33/10; A23L33/105; A61K8/60; A61P29/00; A61Q13/00; A61Q19/00
Domestic Patent References:
| WO2005105126A1 | 2005-11-10 | |||
| WO2020255989A1 | 2020-12-24 |
Foreign References:
| JP2016175861A | 2016-10-06 |
Other References:
ITOH TOMOHIRO, FUJITA SINGO, KOKETSU MAMORU, HASHIZUME TOSHIHARU: "Citrulluside H and citrulluside T from young watermelon fruit attenuate ultraviolet B radiation‐induced matrix metalloproteinase expression through the scavenging of generated reactive oxygen species in human dermal fibroblasts", PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, WILEY-BLACKWELL PUBLISHING, INC, UNITED STATES, UNITED KINGDOM, vol. 37, no. 5, 1 September 2021 (2021-09-01), United States, United Kingdom , pages 386 - 394, XP093149984, ISSN: 0905-4383, DOI: 10.1111/phpp.12669
NINOMIYA MASAYUKI; ITOH TOMOHIRO; FUJITA SHINGO; HASHIZUME TOSHIHARU; KOKETSU MAMORU: "Phenolic glycosides from young fruits of Citrullus lanatus", PHYTOCHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, 23 October 2020 (2020-10-23), AMSTERDAM, NL , pages 135 - 138, XP086366770, ISSN: 1874-3900, DOI: 10.1016/j.phytol.2020.09.014
PODURI ARUNA; RATERI DEBRA L.; SAHA SHUBIN K.; SAHA SIBU; DAUGHERTY ALAN: "Citrullus lanatus 'sentinel' (watermelon) extract reduces atherosclerosis in LDL receptor-defici", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 5, 16 August 2012 (2012-08-16), AMSTERDAM, NL , pages 882 - 886, XP028586063, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2012.05.011
HONG MEE YOUNG, HARTIG NICOLE, KAUFMAN KATY, HOOSHMAND SHIRIN, FIGUEROA ARTURO, KERN MARK: "Watermelon consumption improves inflammation and antioxidant capacity in rats fed an atherogenic diet", NUTRITION RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 3, 1 March 2015 (2015-03-01), AMSTERDAM, NL, pages 251 - 258, XP093149987, ISSN: 0271-5317, DOI: 10.1016/j.nutres.2014.12.005
ITOH TOMOHIRO, MURAMATSU MAI, MIYAZONO DAIKI, KOKETSU MAMORU, FUJITA SHINGO, HASHIZUME TOSHIHARU: "Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon ( Citrullus lanatus ) Fruit Have Beneficial Effects Against Cutibacterium acnes -Induced Skin Inflammation", NATURAL PRODUCT COMMUNICATIONS, NATURAL PRODUCT INC., US, vol. 18, no. 1, 1 January 2023 (2023-01-01), US , XP093149996, ISSN: 1934-578X, DOI: 10.1177/1934578X221143202
KIM HYEON-MI, MOON MI-YEON, HYUN CHANG-GU: "Citrulluside T, Isolated from the Citrullus lanatus Stem, Inhibits Melanogenesis in α-MSH-Induced Mouse B16F10 Cells", COSMETICS, MDPI AG, vol. 10, no. 4, 21 July 2023 (2023-07-21), pages 108, XP093150003, ISSN: 2079-9284, DOI: 10.3390/cosmetics10040108
NINOMIYA MASAYUKI; ITOH TOMOHIRO; FUJITA SHINGO; HASHIZUME TOSHIHARU; KOKETSU MAMORU: "Phenolic glycosides from young fruits of Citrullus lanatus", PHYTOCHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, 23 October 2020 (2020-10-23), AMSTERDAM, NL , pages 135 - 138, XP086366770, ISSN: 1874-3900, DOI: 10.1016/j.phytol.2020.09.014
PODURI ARUNA; RATERI DEBRA L.; SAHA SHUBIN K.; SAHA SIBU; DAUGHERTY ALAN: "Citrullus lanatus 'sentinel' (watermelon) extract reduces atherosclerosis in LDL receptor-defici", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 5, 16 August 2012 (2012-08-16), AMSTERDAM, NL , pages 882 - 886, XP028586063, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2012.05.011
HONG MEE YOUNG, HARTIG NICOLE, KAUFMAN KATY, HOOSHMAND SHIRIN, FIGUEROA ARTURO, KERN MARK: "Watermelon consumption improves inflammation and antioxidant capacity in rats fed an atherogenic diet", NUTRITION RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 3, 1 March 2015 (2015-03-01), AMSTERDAM, NL, pages 251 - 258, XP093149987, ISSN: 0271-5317, DOI: 10.1016/j.nutres.2014.12.005
ITOH TOMOHIRO, MURAMATSU MAI, MIYAZONO DAIKI, KOKETSU MAMORU, FUJITA SHINGO, HASHIZUME TOSHIHARU: "Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon ( Citrullus lanatus ) Fruit Have Beneficial Effects Against Cutibacterium acnes -Induced Skin Inflammation", NATURAL PRODUCT COMMUNICATIONS, NATURAL PRODUCT INC., US, vol. 18, no. 1, 1 January 2023 (2023-01-01), US , XP093149996, ISSN: 1934-578X, DOI: 10.1177/1934578X221143202
KIM HYEON-MI, MOON MI-YEON, HYUN CHANG-GU: "Citrulluside T, Isolated from the Citrullus lanatus Stem, Inhibits Melanogenesis in α-MSH-Induced Mouse B16F10 Cells", COSMETICS, MDPI AG, vol. 10, no. 4, 21 July 2023 (2023-07-21), pages 108, XP093150003, ISSN: 2079-9284, DOI: 10.3390/cosmetics10040108
Attorney, Agent or Firm:
HIROKOH Masaki (JP)
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