Title:
ANTI-INFLAMMATORY COMPOSITION CONTAINING 5-HYDROXYMALTOL
Document Type and Number:
WIPO Patent Application WO/2023/224166
Kind Code:
A1
Abstract:
The present invention relates to an anti-inflammatory composition containing 5-hydroxymaltol, and a composition for preventing, ameliorating, or treating inflammatory diseases, and according to the present invention, 5-hydroxymaltol inhibits NO generation, iNOS expression, and ROS accumulation, and controls signal transmission of MAPK, NF-κB, and Nrf-2/HO-1 to be effective as an anti-inflammatory agent, and thus can be effectively used in preventing, ameliorating, or treating inflammatory diseases.
Inventors:
LEE DONG SUN (KR)
CHOI HACK SUN (KR)
CHOI HACK SUN (KR)
Application Number:
PCT/KR2022/010110
Publication Date:
November 23, 2023
Filing Date:
July 12, 2022
Export Citation:
Assignee:
JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K31/351; A23L33/10; A61K8/49; A61P29/00; A61Q19/00
Domestic Patent References:
| WO2020167663A1 | 2020-08-20 | |||
| WO2008134712A2 | 2008-11-06 | |||
| WO2010129138A2 | 2010-11-11 |
Other References:
KARUNANITHI M, RAJ C DAVID, JEGADEESAN M, KAVIMANI S: "COMPARATIVE GC-MS ANALYSIS AND IN VITRO SCREENING OF FOUR SPECIES OF MUCUNA", ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH, INDORE, IN, vol. 5, no. 4, 1 January 2012 (2012-01-01), IN , pages 239 - 243, XP093109357, ISSN: 0974-2441
JUNG JI-SUN, CHOI MIN-JI, LEE YU YOUNG, MOON BYUNG-IN, PARK JIN-SUN, KIM HEE-SUN: "Suppression of Lipopolysaccharide-Induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway Modulation", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 2, 18 January 2017 (2017-01-18), US , pages 373 - 382, XP093109361, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.6b05147
KIM SU-LIM, CHOI HACK SUN, KO YU-CHAN, YUN BONG-SIK, LEE DONG-SUN: "5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression", ANTIOXIDANTS, MDPI AG, vol. 10, no. 8, 23 August 2021 (2021-08-23), pages 1324, XP093109364, ISSN: 2076-3921, DOI: 10.3390/antiox10081324
JUNG JI-SUN, CHOI MIN-JI, LEE YU YOUNG, MOON BYUNG-IN, PARK JIN-SUN, KIM HEE-SUN: "Suppression of Lipopolysaccharide-Induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway Modulation", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 2, 18 January 2017 (2017-01-18), US , pages 373 - 382, XP093109361, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.6b05147
KIM SU-LIM, CHOI HACK SUN, KO YU-CHAN, YUN BONG-SIK, LEE DONG-SUN: "5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression", ANTIOXIDANTS, MDPI AG, vol. 10, no. 8, 23 August 2021 (2021-08-23), pages 1324, XP093109364, ISSN: 2076-3921, DOI: 10.3390/antiox10081324
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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