Title:
ANTI-INFLAMMATORY DRUG AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/121862
Kind Code:
A1
Abstract:
This anti-inflammatory drug, which contains a G0/G1 switch 2 (G0S2) inhibitor as the active ingredient, is useful as a novel anti-inflammatory drug.
Inventors:
OHDO SHIGEHIRO (JP)
MATSUNAGA NAOYA (JP)
OJIDA AKIO (JP)
SHINDO NAOYA (JP)
MATSUNAGA NAOYA (JP)
OJIDA AKIO (JP)
SHINDO NAOYA (JP)
Application Number:
PCT/JP2016/052470
Publication Date:
August 04, 2016
Filing Date:
January 28, 2016
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/155; A61K31/7105; A61K31/713; A61K48/00; A61P1/16; A61P29/00; A61P35/00; A61P43/00; C07C279/04; C07C279/16; C07C279/18; C12N15/113; C12Q1/68
Domestic Patent References:
| WO1999002145A1 | 1999-01-21 |
Foreign References:
| JP2014530813A | 2014-11-20 | |||
| JPH06506455A | 1994-07-21 | |||
| JPH09255589A | 1997-09-30 | |||
| JP2000515895A | 2000-11-28 | |||
| FR2147881A1 | 1973-03-11 | |||
| US3109859A | 1963-11-05 |
Other References:
CRISTILLO, A.D. ET AL.: "Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (GOS2) in cultured human blood mononuclear cells", DNA CELL BIOL., vol. 16, no. 12, 1997, pages 1449 - 1458
CHIKAKO TANAKA ET AL., NEW YAKURIGAKU, 1997, pages 467 - 469
XIN LU ET AL.: "NF-KB increased expression of 17beta-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol", MOL. CELL ENDOCRINOL., vol. 401, 2015, pages 1 - 11
CHEN, CHUN-YEN ET AL.: "One-flask' transformation of isocyanates and isothiocyanates to guanidines hydrochloride by using sodium bis(trimethylsilyl)amide", TETRAHEDRON, vol. 66, no. 10, 2010, pages 1892 - 1897
BOGUSZEWSKI, PAUL A. ET AL.: "Modular Three- Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 6, no. 1, 2004, pages 32 - 34
GOESSNITZER, EDITH ET AL.: "Novel high energy intermediate analogues with a triazasterol structure as potential ergosterol biosynthesis inhibitors IV: Antimicrobial activity of mono-, bi-, and tricyclic 8,13,15-triazasteroid analogues including the synthesis of novel 4-alkylamino- and 4-alkenylamino-9- hydroxypyrimidoisoquinol", ARCHIV DER PHARMAZIE, vol. 336, no. 6-7, 2003, pages 336 - 344
GOESSNITZER, EDITH ET AL.: "Novel high energy intermediate analogs with triazasterol-related structures as inhibitors of ergosterol biosynthesis. Part I: Synthesis and antifungal activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines", ARCHIV DER PHARMAZIE, vol. 335, 2002, pages 535 - 546
MCKAY, A. F. ET AL.: "Bacteriostats. VI. Bacteriostatic activities of some substituted guanidines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 6, no. 5, 1963, pages 587 - 595
NEIDLEIN, RICHARD ET AL., N-ACYLCARBODIIMIDES, ARCHIV DER PHARMAZIE, vol. 299, no. 8, 1966, pages 709 - 714
O'DONOVAN, DANIEL H. ET AL.: "A concise synthesis of asymmetrical N,N'-disubstituted guanidines", TETRAHEDRON LETTERS, vol. 52, no. 32, 2011, pages 4117 - 4119
MA, DAWEI ET AL.: "Aromatic Nucleophilic Substitution or CuI-Catalyzed Coupling Route to Martinellic Acid", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 2, 2003, pages 442 - 451
LINTON, BRIAN R. ET AL.: "A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 5, 2000, pages 1566 - 1568
CHIKAKO TANAKA ET AL., NEW YAKURIGAKU, 1997, pages 467 - 469
XIN LU ET AL.: "NF-KB increased expression of 17beta-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol", MOL. CELL ENDOCRINOL., vol. 401, 2015, pages 1 - 11
CHEN, CHUN-YEN ET AL.: "One-flask' transformation of isocyanates and isothiocyanates to guanidines hydrochloride by using sodium bis(trimethylsilyl)amide", TETRAHEDRON, vol. 66, no. 10, 2010, pages 1892 - 1897
BOGUSZEWSKI, PAUL A. ET AL.: "Modular Three- Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 6, no. 1, 2004, pages 32 - 34
GOESSNITZER, EDITH ET AL.: "Novel high energy intermediate analogues with a triazasterol structure as potential ergosterol biosynthesis inhibitors IV: Antimicrobial activity of mono-, bi-, and tricyclic 8,13,15-triazasteroid analogues including the synthesis of novel 4-alkylamino- and 4-alkenylamino-9- hydroxypyrimidoisoquinol", ARCHIV DER PHARMAZIE, vol. 336, no. 6-7, 2003, pages 336 - 344
GOESSNITZER, EDITH ET AL.: "Novel high energy intermediate analogs with triazasterol-related structures as inhibitors of ergosterol biosynthesis. Part I: Synthesis and antifungal activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines", ARCHIV DER PHARMAZIE, vol. 335, 2002, pages 535 - 546
MCKAY, A. F. ET AL.: "Bacteriostats. VI. Bacteriostatic activities of some substituted guanidines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 6, no. 5, 1963, pages 587 - 595
NEIDLEIN, RICHARD ET AL., N-ACYLCARBODIIMIDES, ARCHIV DER PHARMAZIE, vol. 299, no. 8, 1966, pages 709 - 714
O'DONOVAN, DANIEL H. ET AL.: "A concise synthesis of asymmetrical N,N'-disubstituted guanidines", TETRAHEDRON LETTERS, vol. 52, no. 32, 2011, pages 4117 - 4119
MA, DAWEI ET AL.: "Aromatic Nucleophilic Substitution or CuI-Catalyzed Coupling Route to Martinellic Acid", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 2, 2003, pages 442 - 451
LINTON, BRIAN R. ET AL.: "A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 5, 2000, pages 1566 - 1568
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Sumio Tanai (JP)
Sumio Tanai (JP)
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