Title:
ANTI-MALARIAL AGENT
Document Type and Number:
WIPO Patent Application WO/2015/105184
Kind Code:
A1
Abstract:
The objective of the present invention is to prevent and/or treat malaria with an anti-malarial agent comprising, as an active ingredient, a metal chelator such as Tris(2-pyridylmethyl)amine represented by formula (I), (III), (IV), (V), (VI), or (VII). (I) (III) (IV) (V) (VI) (VII)
More Like This:
| JP5847533 | New thyroid hormone β-receptor agonist |
| JP2013530230 | Compounds for the treatment of disability and disease in the posterior plot |
| WO/2002/034748 | IMIDAZOPYRIDINE DERIVATIVES |
Inventors:
WADA AKIRA (JP)
HAYASE HIROKI (JP)
WATANABE NOBUMOTO (JP)
OSADA HIROYUKI (JP)
SHIMIZU TAKESHI (JP)
WIERZBA KONSTANTY (JP)
HAYASE HIROKI (JP)
WATANABE NOBUMOTO (JP)
OSADA HIROYUKI (JP)
SHIMIZU TAKESHI (JP)
WIERZBA KONSTANTY (JP)
Application Number:
PCT/JP2015/050513
Publication Date:
July 16, 2015
Filing Date:
January 09, 2015
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K31/444; A61K31/4439; A61K31/4745; A61P33/06
Foreign References:
| JP2000503982A | 2000-04-04 | |||
| JP2014002428A | 2014-01-09 |
Other References:
KITJAROENTHAM, A. ESDMSM160: "EFFECT OF METALLOPR cell by Plasmodium falciparum", ACTA TROPICA, vol. 97, no. 1, 2006, pages REF: - CITATIO, XP025061521, DOI: ACTIVITY ISR (INT. SRCH RPT)
YAPI, A.D. ET AL.: "New potential antimalarial agents: synthesis and biological activities of original diaza-analogs of phenanthrene", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 48, no. 12, 2000, pages 1886 - 1889, XP055357104
YAPI, A.D. ET AL.: "In vitro and in vivo antimalarial activity of derivatives of 1,10- phenanthroline framework", ARCHIV DER PHARMAZIE, vol. 339, no. 4, 2006, pages 201 - 206, XP055357117
SALL, C. ET AL.: "Design, synthesis, and biological activities of conformationally restricted analogs of primaquine with a 1,10- phenanthroline framework", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 16, 2008, pages 4666 - 4669, XP023613445
KUTER, D. ET AL.: "Linear free energy relationships predict coordination and PI - stacking interactions of small molecules with ferriprotoporphyrin IX", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, no. 5, 2011, pages 684 - 692, XP028195037
EGAN, T.J. ET AL.: "In Vitro Antimalarial Activity of a Series of Cationic 2,2'- Bipyridyl-and 1,10-Phenanthrolineplatinum(II) Benzoylthiourea Complexes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 11, 2004, pages 2926 - 2934, XP055357129
RASOLOSON, D. ET AL.: "Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase", THE BIOCHEMICAL JOURNAL, vol. 381, no. 3, 1 August 2004 (2004-08-01), pages 803 - 811, XP055357135
MARVIN, R.G. ET AL.: "Fluxes in ''Free'' and Total Zinc Are Essential for Progression of Intraerythrocytic Stages of Plasmodium falciparum", CHEMISTRY & BIOLOGY, vol. 19, no. 6, 2012, pages 731 - 741, XP028497236
MARVIN RG ET AL., CHEM BIOL., vol. 19, no. 6, 22 June 2012 (2012-06-22), pages 731 - 41
GINSBURG H ET AL., BIOCHIM BIOPHYS ACTA, vol. 886, no. 3, 29 May 1986 (1986-05-29), pages 337 - 44
GLICKSTEIN H ET AL., BLOOD, vol. 87, no. 11, 1 June 1996 (1996-06-01), pages 4871 - 8
See also references of EP 3093020A4
YAPI, A.D. ET AL.: "New potential antimalarial agents: synthesis and biological activities of original diaza-analogs of phenanthrene", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 48, no. 12, 2000, pages 1886 - 1889, XP055357104
YAPI, A.D. ET AL.: "In vitro and in vivo antimalarial activity of derivatives of 1,10- phenanthroline framework", ARCHIV DER PHARMAZIE, vol. 339, no. 4, 2006, pages 201 - 206, XP055357117
SALL, C. ET AL.: "Design, synthesis, and biological activities of conformationally restricted analogs of primaquine with a 1,10- phenanthroline framework", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 16, 2008, pages 4666 - 4669, XP023613445
KUTER, D. ET AL.: "Linear free energy relationships predict coordination and PI - stacking interactions of small molecules with ferriprotoporphyrin IX", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, no. 5, 2011, pages 684 - 692, XP028195037
EGAN, T.J. ET AL.: "In Vitro Antimalarial Activity of a Series of Cationic 2,2'- Bipyridyl-and 1,10-Phenanthrolineplatinum(II) Benzoylthiourea Complexes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 11, 2004, pages 2926 - 2934, XP055357129
RASOLOSON, D. ET AL.: "Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase", THE BIOCHEMICAL JOURNAL, vol. 381, no. 3, 1 August 2004 (2004-08-01), pages 803 - 811, XP055357135
MARVIN, R.G. ET AL.: "Fluxes in ''Free'' and Total Zinc Are Essential for Progression of Intraerythrocytic Stages of Plasmodium falciparum", CHEMISTRY & BIOLOGY, vol. 19, no. 6, 2012, pages 731 - 741, XP028497236
MARVIN RG ET AL., CHEM BIOL., vol. 19, no. 6, 22 June 2012 (2012-06-22), pages 731 - 41
GINSBURG H ET AL., BIOCHIM BIOPHYS ACTA, vol. 886, no. 3, 29 May 1986 (1986-05-29), pages 337 - 44
GLICKSTEIN H ET AL., BLOOD, vol. 87, no. 11, 1 June 1996 (1996-06-01), pages 4871 - 8
See also references of EP 3093020A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
Download PDF: