Title:
ANTI-MESOTHELIN ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2024/012395
Kind Code:
A1
Abstract:
Provided are antibodies that bind to mesothelin and antigen-binding fragments thereof, as well as uses thereof, nucleic acids encoding the antibodies and antigen-binding fragments, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also provided are pharmaceutical compositions and conjugates comprising the antibodies, and therapeutic methods by administering the antibodies.
Inventors:
ZHANG MEIHONG (CN)
WANG DI (CN)
WANG XIAOXIAO (CN)
GUAN GUANGKUO (CN)
DENG CHANGJING (CN)
WANG DI (CN)
WANG XIAOXIAO (CN)
GUAN GUANGKUO (CN)
DENG CHANGJING (CN)
Application Number:
PCT/CN2023/106519
Publication Date:
January 18, 2024
Filing Date:
July 10, 2023
Export Citation:
Assignee:
NONA BIOSCIENCES SUZHOU CO LTD (CN)
International Classes:
A61K39/00; C07K16/28; A61P35/00; C07K16/30
Domestic Patent References:
| WO2021207242A2 | 2021-10-14 | |||
| WO2020011970A1 | 2020-01-16 | |||
| WO2017021356A1 | 2017-02-09 | |||
| WO2017032293A1 | 2017-03-02 | |||
| WO2022078286A1 | 2022-04-21 |
Other References:
FUJII, Y. ET AL.: "Early administration of amatuximab, a chimeric high-affinity anti-mesothelin monoclonal antibody, suppresses liver metastasis of mesothelin-expressing pancreatic cancer cells and enhances gemcitabine sensitivity in a xenograft mouse model", INVESTIGATIONAL NEW DRUGS, vol. 39, 27 April 2021 (2021-04-27), XP037558150, DOI: 10.1007/s10637-021-01118-1
WANG XUDONG, WANG FENG, HAN JINTAO, YANG ZHI, ZHU HUA, YANG GEN: "Construction and Preclinical Evaluation of a 124/131 I-Labeled Radiotracer for the Detection of Mesothelin-Overexpressing Cancer", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 6, 1 June 2020 (2020-06-01), US , pages 1875 - 1883, XP093127434, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b01281
WANG XUDONG, WANG FENG, HAN JINTAO, YANG ZHI, ZHU HUA, YANG GEN: "Construction and Preclinical Evaluation of a 124/131 I-Labeled Radiotracer for the Detection of Mesothelin-Overexpressing Cancer", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 6, 1 June 2020 (2020-06-01), US , pages 1875 - 1883, XP093127434, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b01281
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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