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Title:
ANTI-NEURODEGENERATIVE DISEASE AGENT
Document Type and Number:
WIPO Patent Application WO/2010/087306
Kind Code:
A1
Abstract:
Disclosed is a novel anti-neurodegenerative disease agent.  The anti-neurodegenerative disease agent comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represent a hydrogen atom or a proper substituent; Z1 represents a heterocyclic ring, and Z2 represents a heterocyclic ring which is the same as or different from the heterocyclic ring represented by Z1, or an aromatic ring, wherein each of the heterocyclic ring and the aromatic ring may have a substituent; o represents an integer of 0, 1 or 2, and p represents an integer of 0 or 1, wherein p is 1 when o is 0 or 2, p is 0 when o is 1, R1 and R2 do not exist when o is 0, and R3 does not exist and a carbon atom to which R2 is bound and Z2 are bound to each other through a single bond when p is 0; X1 - represents a proper counter anion; and q represents an integer of 1 or 2.

Inventors:
OHTA HITOMI (JP)
AKITA KENJI (JP)
OHTA TSUNETAKA (JP)
KAWATA TOSHIO (JP)
FUKUDA SHIGEHARU (JP)
Application Number:
PCT/JP2010/050903
Publication Date:
August 05, 2010
Filing Date:
January 25, 2010
Export Citation:
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Assignee:
HAYASHIBARA BIOCHEM LAB (JP)
OHTA HITOMI (JP)
AKITA KENJI (JP)
OHTA TSUNETAKA (JP)
KAWATA TOSHIO (JP)
FUKUDA SHIGEHARU (JP)
International Classes:
A61K31/352; A61K31/4709; A61K31/381; A61K31/403; A61K31/404; A61K31/4045; A61K31/41; A61K31/4152; A61K31/4155; A61K31/4184; A61K31/42; A61K31/421; A61K31/422; A61K31/423; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4439; A61K31/444; A61K31/47; A61K31/4706; A61K31/501; A61P11/00; A61P21/02; A61P21/04; A61P25/02; A61P25/14; A61P25/16; A61P25/24; A61P25/28; C07D209/14; C07D209/60; C07D213/34; C07D215/12; C07D231/22; C07D235/20; C07D261/12; C07D263/32; C07D263/56; C07D277/20; C07D277/30; C07D277/36; C07D277/64; C07D277/84; C07D311/74; C07D333/32; C07D333/64; C07D405/06; C07D413/06; C07D417/06
Domestic Patent References:
WO2009003147A12008-12-31
WO2007041358A22007-04-12
WO2002090314A12002-11-14
WO2002007781A22002-01-31
WO2004050088A12004-06-17
WO2003106439A12003-12-24
WO1997030703A11997-08-28
WO2003067979A12003-08-21
WO2004022543A12004-03-18
WO2005012255A12005-02-10
WO2002000260A12002-01-03
WO2003024446A12003-03-27
WO2004063167A12004-07-29
Foreign References:
JP2002121416A2002-04-23
JP2005505519A2005-02-24
US20030013656A12003-01-16
JP2000355579A2000-12-26
JP2002518380A2002-06-25
JP2005514368A2005-05-19
JP2003534341A2003-11-18
US20060018825A12006-01-26
JP2004250407A2004-09-09
JP2003137784A2003-05-14
JPH11228417A1999-08-24
JP2006143708A2006-06-08
JP2006321737A2006-11-30
JP2002234841A2002-08-23
JPH0531523B21993-05-12
JPH0535128B21993-05-25
JP2906512B21999-06-21
JP2906513B21999-06-21
JPH0725765A1995-01-27
JPH0952801A1997-02-25
JPH1179991A1999-03-23
JPH0952831A1997-02-25
JP2004099560A2004-04-02
JPH10279480A1998-10-20
JP2004131402A2004-04-30
JP2006096664A2006-04-13
JP2006182677A2006-07-13
JP2003335674A2003-11-25
JP2004277315A2004-10-07
JP2005029573A2005-02-03
JP2004137252A2004-05-13
JP2004137253A2004-05-13
JP2004143149A2004-05-20
JP2003252760A2003-09-10
JP2004123713A2004-04-22
JP2004137256A2004-05-13
JP2004161720A2004-06-10
JP2004331653A2004-11-25
JP2008037753A2008-02-21
JP2004339214A2004-12-02
JP2005089456A2005-04-07
JP2005162749A2005-06-23
JP2008247813A2008-10-16
JP2003300880A2003-10-21
JP2008193941A2008-08-28
Other References:
J.BIOLOGICAL CHEMISTRY, vol. 280, no. 9, 2005, pages 7614 - 7623, XP003014102
BIOCHEMISTRY, vol. 45, no. 19, 2006, pages 6085 - 6094, XP002436919
EUROPEAN J.PHARMACOLOGY, vol. 559, no. 2-3, 2007, pages 124 - 131, XP005907818
"Kankoso-Hyo", 1969, KANKOSHIKISO-KENKYU-SHO
CHEMICAL ABSTRACT INDEX GUIDE (N-Z, 1994, pages 1531G - 1536G
KASE H. ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 144, 1987, pages 35 - 40
VLAHOS C. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 5241-5, 1994
RENAE L. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 1999, pages 35499
WANLI W. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 17649 - 17656
AKITA K. ET AL., J. NEUROGENETICS, vol. 21, 2007, pages 19 - 29
FERNANDEZ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 1253 - 1258
RIVLIN ET AL., J. NEUROSURG., vol. 47, 1997, pages 577 - 581
HILAL A. LASHUEL ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 45, 2002, pages 42881 - 42890
KOIZUMI ET AL., CEREBRAL STROKE, vol. 8, no. 1, 1986, pages 1 - 8
PETULLO D. ET AL., LIFE SCIENCES, vol. 64, no. 13, 1999, pages 1099 - 1108
BENDERSON J. B. ET AL., STROKE, vol. 17, 1986, pages 1304 - 1308
"FREE RADICAL MONITOR JES-FR30", JOEL LTD.
NIHON-YAKURIGAKU-ZASSHI, vol. 119, 2002, pages 301 - 308
BRAIN RESEARCH, vol. 706, 1996, pages 181 - 193
See also references of EP 2397139A4
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