Title:
ANTI-PANCREATIC CANCER POLYPEPTIDE DRUG CONJUGATE, AND CARRIER-FREE SELF-ASSEMBLY NANO DRUG THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/109618
Kind Code:
A1
Abstract:
Disclosed are an anti-pancreatic cancer polypeptide drug conjugate, and a carrier-free self-assembly nano drug thereof, and a preparation method therefor and the use thereof. The anti-pancreatic cancer polypeptide drug conjugate takes an active oxygen response fragment as a connecting arm, and chemically conjugates the pro-apoptotic peptide SmacN7 and gemcitabine. The carrier-free nano drug is formed by means of self-assembling the polypeptide drug conjugate and a photosensitizer molecule chlorin e6 (Ce6) by means of a one-step nano-precipitation method. The provided carrier-free nano drug has the advantages of small and uniform particle size, good stability, etc., can release the chemotherapeutic drug gemcitabine and the pro-apoptotic peptide SmacN7 as needed under the illumination stimulation of 630-670 nm in tumor cells, synergizes the effects of photodynamic therapy and chemotherapy, can significantly improve an anti-tumor effect thereof, and has an excellent clinical conversion prospect.
Inventors:
GENG JIN (CN)
ZHU LIWEI (CN)
ZHANG YICHUAN (CN)
LIN SHANMENG (CN)
XU YOUWEI (CN)
WANG LIANG (CN)
ZHU LIWEI (CN)
ZHANG YICHUAN (CN)
LIN SHANMENG (CN)
XU YOUWEI (CN)
WANG LIANG (CN)
Application Number:
PCT/CN2022/137362
Publication Date:
June 22, 2023
Filing Date:
December 07, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K38/08; A61K47/64; A61P35/00
Foreign References:
| CN102264396A | 2011-11-30 | |||
| CN106279321A | 2017-01-04 | |||
| CN112794917A | 2021-05-14 |
Other References:
ZHU LIWEI, LIN SHANMENG, CUI WENQIANG, XU YOUWEI, WANG LIANG, WANG ZHAOHAN, YUAN SHUGUANG, ZHANG YICHUAN, FAN YINGFANG, GENG JIN: "A nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 10, no. 13, 28 June 2022 (2022-06-28), GB , pages 3624 - 3636, XP093072871, ISSN: 2047-4830, DOI: 10.1039/D2BM00437B
ZHOU WUYUAN, SHI JUN, NIU ZUOXING, LUO HONGMIN, TIAN HE, GAO JIE, YU FACHANG, LI SHENG: "SmacN7 enhances the sensitivity of pancreatic cancer cells to tumor necrosis factor-related apoptosis-inducing ligand or gemcitabine", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 5, no. 6, 1 June 2013 (2013-06-01), GR , pages 1760 - 1764, XP093072873, ISSN: 1792-1074, DOI: 10.3892/ol.2013.1285
FAN RANGRANG, MEI LAN, GAO XIANG, WANG YUELONG, XIANG MINGLI, ZHENG YU, TONG AIPING, ZHANG XIAONING, HAN BO, ZHOU LIANGXUE, MI PEN: "Self-Assembled Bifunctional Peptide as Effective Drug Delivery Vector with Powerful Antitumor Activity", ADVANCED SCIENCE, vol. 4, no. 4, 1 April 2017 (2017-04-01), pages 1600285, XP093072876, ISSN: 2198-3844, DOI: 10.1002/advs.201600285
ZHOU WUYUAN, SHI JUN, NIU ZUOXING, LUO HONGMIN, TIAN HE, GAO JIE, YU FACHANG, LI SHENG: "SmacN7 enhances the sensitivity of pancreatic cancer cells to tumor necrosis factor-related apoptosis-inducing ligand or gemcitabine", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 5, no. 6, 1 June 2013 (2013-06-01), GR , pages 1760 - 1764, XP093072873, ISSN: 1792-1074, DOI: 10.3892/ol.2013.1285
FAN RANGRANG, MEI LAN, GAO XIANG, WANG YUELONG, XIANG MINGLI, ZHENG YU, TONG AIPING, ZHANG XIAONING, HAN BO, ZHOU LIANGXUE, MI PEN: "Self-Assembled Bifunctional Peptide as Effective Drug Delivery Vector with Powerful Antitumor Activity", ADVANCED SCIENCE, vol. 4, no. 4, 1 April 2017 (2017-04-01), pages 1600285, XP093072876, ISSN: 2198-3844, DOI: 10.1002/advs.201600285
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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