Title:
ANTI-PD-1 ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/016497
Kind Code:
A1
Abstract:
Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
Inventors:
LIU LILE (CN)
YANG XINXIU (CN)
LUO HAISHAN (CN)
LIU HU (CN)
SHUAI ZHENGRONG (CN)
WANG JIAN (CN)
ZHONG QIN (CN)
DUAN QING (CN)
GU HONGZHUAN (CN)
YANG TATCHI TEDDY (CN)
YANG XINXIU (CN)
LUO HAISHAN (CN)
LIU HU (CN)
SHUAI ZHENGRONG (CN)
WANG JIAN (CN)
ZHONG QIN (CN)
DUAN QING (CN)
GU HONGZHUAN (CN)
YANG TATCHI TEDDY (CN)
Application Number:
PCT/CN2016/091962
Publication Date:
February 02, 2017
Filing Date:
July 27, 2016
Export Citation:
Assignee:
HARBOUR BIOMED LTD (GB)
LIU LILE (CN)
LIU LILE (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12N15/63
Domestic Patent References:
| WO2004056875A1 | 2004-07-08 | |||
| WO2006121168A1 | 2006-11-16 |
Other References:
BLANK ET AL., CANCER IMMUNOTHERAPY, vol. 54, 2005, pages 307 - 314
FREEMAN ET AL., J. EXP. MED., vol. 192, 2000, pages 1027 - 34
ZIPPELIUS ET AL., CANCER IMMUNOL RES., vol. 3, no. 3, 2015, pages 236 - 44
WHERRY, NAT. IMMUNOL., vol. 12, 2011, pages 492 - 99
BRAHMER ET AL., J. CLIN. ONCOL., vol. 28, 2010, pages 3167 - 75
GREENWALD ET AL., ANNU. REV. IMMUNOL., vol. 23, 2005, pages 515 - 48
HARDINGLONBERG, ANN. N.Y. ACAD. SCI., vol. 764, 1995, pages 536 - 546
HIRANO ET AL., CANCER RES., vol. 65, 2005, pages 1089 - 96
KABAT: "Sequences of proteins of objective interest", 1991, NIH
KIPRIYANOV ET AL., PEDS., vol. 10, 1997, pages 445 - 453
LONBERGHUSZAR, INTERNAL REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
LONBERG ET AL., NATURE, vol. 368, 1994, pages 856 - 859
SAMBROOKRUSSELL: "Molecular cloning: a laboratory manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SHARPE ET AL., NAT. IMMUNOL., vol. 8, 2007, pages 239 - 45
TOPALIAN ET AL., J. CLIN. ONCOL., vol. 32, 2014, pages 1020 - 30
WEINSTOCKMCDERMOTT, THERADV UROL., vol. 7, no. 6, 2015, pages 365 - 77
ZOUCHEN L, NAT REV IMMUNOL., vol. 8, no. 6, 2008, pages 467 - 77
See also references of EP 3328895A4
FREEMAN ET AL., J. EXP. MED., vol. 192, 2000, pages 1027 - 34
ZIPPELIUS ET AL., CANCER IMMUNOL RES., vol. 3, no. 3, 2015, pages 236 - 44
WHERRY, NAT. IMMUNOL., vol. 12, 2011, pages 492 - 99
BRAHMER ET AL., J. CLIN. ONCOL., vol. 28, 2010, pages 3167 - 75
GREENWALD ET AL., ANNU. REV. IMMUNOL., vol. 23, 2005, pages 515 - 48
HARDINGLONBERG, ANN. N.Y. ACAD. SCI., vol. 764, 1995, pages 536 - 546
HIRANO ET AL., CANCER RES., vol. 65, 2005, pages 1089 - 96
KABAT: "Sequences of proteins of objective interest", 1991, NIH
KIPRIYANOV ET AL., PEDS., vol. 10, 1997, pages 445 - 453
LONBERGHUSZAR, INTERNAL REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
LONBERG ET AL., NATURE, vol. 368, 1994, pages 856 - 859
SAMBROOKRUSSELL: "Molecular cloning: a laboratory manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SHARPE ET AL., NAT. IMMUNOL., vol. 8, 2007, pages 239 - 45
TOPALIAN ET AL., J. CLIN. ONCOL., vol. 32, 2014, pages 1020 - 30
WEINSTOCKMCDERMOTT, THERADV UROL., vol. 7, no. 6, 2015, pages 365 - 77
ZOUCHEN L, NAT REV IMMUNOL., vol. 8, no. 6, 2008, pages 467 - 77
See also references of EP 3328895A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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