ANTI-PRION ACTIVE COMPOUND, ANTI-PRION ACTIVE AGENT, AND METHOD FOR INHIBITION OF THE PRODUCTION OF ABNORMAL PRION PROTEIN

Title:

ANTI-PRION ACTIVE COMPOUND, ANTI-PRION ACTIVE AGENT, AND METHOD FOR INHIBITION OF THE PRODUCTION OF ABNORMAL PRION PROTEIN

Document Type and Number:

WIPO Patent Application WO/2008/053764

Kind Code:

A1

Abstract:

[PROBLEMS] To provide an anti-prion active compound having an excellent effect of preventing the increase in the level of an abnormal prion protein, and also provide an anti-prion active agent and a method for inhibiting the production of an abnormal prion protein, both utilizing the anti-prion active compound. [MEANS FOR SOLVING PROBLEMS] The anti-prion active compound is a pyrazolone derivative represented by the general formula (1). (1) wherein R1 represents an aryl group which may have a substituent or an alkyl group (including a cycloalkyl group) which may have a substituent; R2 represents a hydrogen atom, an aryl group which may have a substituent, a nitrogenated heterocyclic functional group which may have a substituent, an alkyl group (including a cycloalkyl group) which may have a substituent or an acyl group ; and R3 represents an aryl group which may have a substituent, an alkyl group (including a cycloalkyl group) which may have a substituent, RCONH-, RNHCO-, ROCONH- or RNHCONH- [wherein R represents an aryl group or an alkyl group (including a cycloalkyl group)].

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Inventors:

MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
NAKAGAWA HIDEHIKO (JP)
OHTA SHIGERU (JP)
DOH-URA KATSUMI (JP)
FUKUUCHI TOMOKO (JP)

Application Number:

PCT/JP2007/070748

Publication Date:

May 08, 2008

Filing Date:

October 24, 2007

Export Citation:

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Assignee:

UNIV NAGOYA CITY (JP)
MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
NAKAGAWA HIDEHIKO (JP)
OHTA SHIGERU (JP)
DOH-URA KATSUMI (JP)
FUKUUCHI TOMOKO (JP)

International Classes:

C07D231/20; A61K31/4152; A61K31/4155; A61K31/4439; A61P25/00; A61P31/00; C07D231/22; C07D231/52; C07D401/04

Domestic Patent References:

WO2006002421A2	2006-01-05
WO2004035522A1	2004-04-29

Foreign References:

US20060223812A1

2006-10-05

Attorney, Agent or Firm:

AOYAMA, Yo (4-6-6 Masaki, Nakaku, Nagoyashi Aichi 24, JP)

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