ANTI-SICKLING AGENTS - UNIV VIRGINIA COMMONWEALTH

Title:

ANTI-SICKLING AGENTS

Document Type and Number:

WIPO Patent Application WO2004050030

Kind Code:

A3

Abstract:

The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.

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Inventors:

SAFO MARTIN K
DANSO-DANQUAH RICHMOND
NOKURI SAMUEL
MUSAYEV FAIK N
JOSHI GAJANAN S
BURNETT JAMES C
ABRAHAM DONALD J

Application Number:

PCT/US2003/038264

Publication Date:

July 29, 2004

Filing Date:

December 03, 2003

Export Citation:

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Assignee:

UNIV VIRGINIA COMMONWEALTH (US)

International Classes:

A61K31/34; A61K31/381; A61K31/40; A61K31/401; A61K31/66; C07D207/30; C07D417/04; (IPC1-7): C07D207/30; C07D307/34; A61K31/34; A61K31/40; A61K31/381

Foreign References:

US4987132A	1991-01-22
US6300332B1	2001-10-09

Other References: