Title:
ANTI-TNFR2 ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/023098
Kind Code:
A1
Abstract:
An antibody or an antigen-binding fragment thereof capable of specifically binding to TNFR2, the antibody or the antigen-binding fragment thereof is capable of regulating the function of immune cells and may be used as a medicament to treat diseases related to immune abnormalities, such as tumors.
Inventors:
ZHAO XINYAN (CN)
ZHAO XIAOFENG (CN)
LU SHIQIANG (CN)
PANG RAN (CN)
LI XINXIN (CN)
REN JINSHENG (CN)
ZHAO XIAOFENG (CN)
LU SHIQIANG (CN)
PANG RAN (CN)
LI XINXIN (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2020/106057
Publication Date:
February 11, 2021
Filing Date:
July 31, 2020
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
SIMCERE BIO PHARMACEUTICAL TECH LTD (CN)
SIMCERE BIO PHARMACEUTICAL TECH LTD (CN)
International Classes:
A61K39/395; C07K16/28; A61P35/00; A61P35/04; C12N15/13
Domestic Patent References:
| WO2017083525A1 | 2017-05-18 |
Foreign References:
| CN109476745A | 2019-03-15 | |||
| CN107849142A | 2018-03-27 | |||
| CN201910713742A | 2019-08-02 |
Other References:
WAHL ET AL., J. NUCL. MED., vol. 24, 1983, pages 316
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
MORRISON, SCIENCE, vol. 229, no. 4719, 1985, pages 1202 - 7
OI ET AL., BIO TECHNIQUES, vol. 4, 1986, pages 224 - 221
GILLIES ET AL., J IMMUNOL METHODS, vol. 125, 1985, pages 191 - 202
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
HARLOWLANE: "Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
HARLOWLANE: "Using Antibodies, A Laboratory Manual", 1999, COLD SPRING HARBOR PRESS
ZARAGOZA B ET AL., NAT MED., vol. 22, no. 1, January 2016 (2016-01-01), pages 16 - 7
ABDICHE YN ET AL., PLOS ONE, 20 March 2014 (2014-03-20)
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
MORRISON, SCIENCE, vol. 229, no. 4719, 1985, pages 1202 - 7
OI ET AL., BIO TECHNIQUES, vol. 4, 1986, pages 224 - 221
GILLIES ET AL., J IMMUNOL METHODS, vol. 125, 1985, pages 191 - 202
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
HARLOWLANE: "Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
HARLOWLANE: "Using Antibodies, A Laboratory Manual", 1999, COLD SPRING HARBOR PRESS
ZARAGOZA B ET AL., NAT MED., vol. 22, no. 1, January 2016 (2016-01-01), pages 16 - 7
ABDICHE YN ET AL., PLOS ONE, 20 March 2014 (2014-03-20)
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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