Title:
ANTI-TUMOR AGENT, ANTI-TUMOR EFFECT ENHANCER, AND ANTI-TUMOR KIT
Document Type and Number:
WIPO Patent Application WO/2018/043530
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an anti-tumor agent having a superior anti-tumor effect compared with a therapy with gemcitabine, paclitaxel or a combination thereof; an anti-tumor kit; and an anti-tumor effect enhancer. According to the present invention, an anti-tumor agent is provided, which comprises paclitaxel or a salt thereof and 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine or a salt or prodrug thereof.
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Inventors:
IWAKI YOSHIHIDE (JP)
KITAHASHI TSUKASA (JP)
MIMA SHINJI (JP)
KITAHASHI TSUKASA (JP)
MIMA SHINJI (JP)
Application Number:
PCT/JP2017/031074
Publication Date:
March 08, 2018
Filing Date:
August 30, 2017
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
A61K31/7068; A61K9/14; A61K31/337; A61K47/42; A61P35/00; A61P43/00
Domestic Patent References:
| WO1997038001A1 | 1997-10-16 | |||
| WO2013146833A1 | 2013-10-03 |
Other References:
MIURA, S. ET AL.: "Comparison of 1-(2-deoxy- 2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity", CANCER LETTERS, vol. 144, 1999, pages 177 - 182, XP055213437, ISSN: 1872-7980, DOI: doi:10.1016/S0304-3835(99)00221-9
VON HOFF, D. D. ET AL.: "Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 369, no. 18, 2013, pages 1691 - 1703, XP055250743, ISSN: 1533-4406, DOI: doi:10.1056/NEJMoa1304369
See also references of EP 3508205A4
VON HOFF, D. D. ET AL.: "Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 369, no. 18, 2013, pages 1691 - 1703, XP055250743, ISSN: 1533-4406, DOI: doi:10.1056/NEJMoa1304369
See also references of EP 3508205A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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