Title:
ANTI-TUMOR COMPOUND AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/034126
Kind Code:
A1
Abstract:
A compound of formula (I) is disclosed, which has a low toxicity, can significantly inhibit the migration and invasion of tumor cells in vitro, and can inhibit tumor metastasis in vivo in mice at low concentration, while showing notable sensitizing effect on cytotoxic anti-tumor drugs such as Paclitaxel etc.
Inventors:
ZHANG NING (CN)
WANG YINSONG (CN)
ZHOU PING (CN)
GUO HUA (CN)
LUO YI (CN)
HAO XISHAN (CN)
GENG HUA (CN)
WANG YINSONG (CN)
ZHOU PING (CN)
GUO HUA (CN)
LUO YI (CN)
HAO XISHAN (CN)
GENG HUA (CN)
Application Number:
PCT/CN2015/088842
Publication Date:
March 10, 2016
Filing Date:
September 02, 2015
Export Citation:
Assignee:
TIANJIN CANCER INST (CN)
International Classes:
C07C233/87; A61K31/192; A61K31/198; A61K31/24; A61P35/00; A61P35/04; C07C63/06; C07C65/03; C07C69/78; C07C231/02
Domestic Patent References:
| WO2011099832A2 | 2011-08-18 | |||
| WO2014086739A1 | 2014-06-12 | |||
| WO2007141473A1 | 2007-12-13 |
Foreign References:
| CN104326937A | 2015-02-04 | |||
| JP2011026301A | 2011-02-10 | |||
| CN102807568A | 2012-12-05 | |||
| CN101627013A | 2010-01-13 |
Other References:
KHALAF, R.A. ET AL.: "Tryptophan and thiosemicarbazide derivatives:design, synthesis, and biological evaluation as potential b-D-galactosidase and b-D-glucosidase inhibitors", MED CHEM RES, vol. 24, 21 December 2014 (2014-12-21), pages 2529 - 2550, ISSN: 1554-8120
DATABASE REGISTRY. Database accession no. RN:1608722-99-1
XU, BIXUE ET AL.: "Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives", BIOORGANIC CHEMISTRY, vol. 56, 2 June 2014 (2014-06-02), pages 34 - 40, ISSN: 0045-2068
RONWIN EDWARD.: "Optical Activity and the Direct Method of Acylation", JOURNAL OF ORGANIC CHEMISTRY, vol. 22, 31 October 1957 (1957-10-31), pages 1180 - 1182, ISSN: 0022-3263
OKANO, SADASUKE ET AL.: "Studies on Azoprotein Immunization. IV. Synthesis of Haptenes (3). Na-Aminobenzoyl-L-histidines and Nw-Aminobenzoylhistamines", YAKUGAKU ZASSHI, vol. 77, no. 10, 31 December 1957 (1957-12-31), pages 1105 - 1107, ISSN: 0031-6903
RIEKER, ANTON ET AL.: "Zur radikalischen Reaktionsweise von Isonitrilen", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 761, 31 December 1972 (1972-12-31), pages 1 - 13, ISSN: 0075-4617
LI, MENGHUI ET AL.: "Basic Research of Cell Migration Inhibitor 4-methyl-3-nitro-benzoic Acid", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 37, no. 11, 31 December 2010 (2010-12-31), pages 601 - 604, ISSN: 1000-8179
LI, MENGHUI ET AL.: "Basic Research of Cell Migration Inhibitor 4-methyl-3-nitro-benzoic Acid", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 37, no. 11, 31 December 2010 (2010-12-31), ISSN: 1000-8179
DATABASE REGISTRY. Database accession no. RN:1608722-99-1
XU, BIXUE ET AL.: "Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives", BIOORGANIC CHEMISTRY, vol. 56, 2 June 2014 (2014-06-02), pages 34 - 40, ISSN: 0045-2068
RONWIN EDWARD.: "Optical Activity and the Direct Method of Acylation", JOURNAL OF ORGANIC CHEMISTRY, vol. 22, 31 October 1957 (1957-10-31), pages 1180 - 1182, ISSN: 0022-3263
OKANO, SADASUKE ET AL.: "Studies on Azoprotein Immunization. IV. Synthesis of Haptenes (3). Na-Aminobenzoyl-L-histidines and Nw-Aminobenzoylhistamines", YAKUGAKU ZASSHI, vol. 77, no. 10, 31 December 1957 (1957-12-31), pages 1105 - 1107, ISSN: 0031-6903
RIEKER, ANTON ET AL.: "Zur radikalischen Reaktionsweise von Isonitrilen", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 761, 31 December 1972 (1972-12-31), pages 1 - 13, ISSN: 0075-4617
LI, MENGHUI ET AL.: "Basic Research of Cell Migration Inhibitor 4-methyl-3-nitro-benzoic Acid", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 37, no. 11, 31 December 2010 (2010-12-31), pages 601 - 604, ISSN: 1000-8179
LI, MENGHUI ET AL.: "Basic Research of Cell Migration Inhibitor 4-methyl-3-nitro-benzoic Acid", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 37, no. 11, 31 December 2010 (2010-12-31), ISSN: 1000-8179
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (No. 87 West 3rd Ring North Rd.,Haidian District, Beijing 9, CN)
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