Title:
ANTI-TUMOR EFFECT AND USE OF DIHETEROCYCLIC RIBAVIRIN ANALOG
Document Type and Number:
WIPO Patent Application WO/2019/052359
Kind Code:
A1
Abstract:
The aim of the present invention is to provide a compound containing a diheterocyclic ribavirin analog, a stereoisomer, a prodrug, a pharmaceutically acceptable salt, a compound salt and/or a solvated compound with structural general formula (I) as follows, and/or a stereoisomer, a tautomer, a prodrug, a pharmaceutically acceptable salt, a compound salt and/or a solvate thereof, which have an anti-tumor effect and use.
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Inventors:
XU LIFENG (CN)
Application Number:
PCT/CN2018/103763
Publication Date:
March 21, 2019
Filing Date:
September 03, 2018
Export Citation:
Assignee:
LIAONING LIFENG SCIENTIFIC & TECH DEVELOPMENT COMPANY LTD (CN)
International Classes:
A61K31/53; C07D487/04; A61K31/675; A61K31/706; A61P35/00; C07F9/6561; C07H1/00; C07H19/23
Domestic Patent References:
| WO2004037159A2 | 2004-05-06 |
Foreign References:
| CN105017258A | 2015-11-04 | |||
| CN101215289A | 2008-07-09 |
Other References:
MANFREDINI, S. ET AL.: "Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4, 3-d]-1, 2, 3-triazin-4-one Nucleosides", J. MED. CHEM., vol. 35, no. 5, 31 March 1992 (1992-03-31), pages 919, XP002018485, ISSN: 0022-2623, DOI: doi:10.1021/jm00083a017
GURENKO, A.O. ET AL.: "Synthesis of Novel Pyrazolo[3, 4-d] [1, 2, 3] Triazines", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 50, no. 4, 30 April 2014 (2014-04-30), XP055583638, ISSN: 0009-3122
CLARK, A.S. ET AL.: "Antitumor Imidazotetrazines. 32.1 Synthesis of Novel Imidazotetrazinones and Related Bicyclic Heterocycles to Probe the Mode of Action of the Antitumor Drug Temozolomide", J. MED. CHEM., vol. 38, no. 9, 30 April 1995 (1995-04-30), pages 1943 - 1504, XP001069007, ISSN: 0022-2623, DOI: doi:10.1021/jm00009a010
SRIVASTAVA, R. ET AL.: "Antithrombotic Effect of Thiopurinol", THROMBOSIS RESEARCH, vol. 54, no. 6, 15 June 1989 (1989-06-15), pages 741 - 749, XP026465095, ISSN: 0049-3848, DOI: doi:10.1016/0049-3848(89)90138-2
CHOI, J.H. ET AL.: "N-Glucosides of Fairy Chemicals, 2-Azahypoxanthine and 2-Aza-8- oxohypoxanthine, in Rice", ORG. LETT., vol. 20, no. 1, 13 December 2017 (2017-12-13), XP055583641, ISSN: 1523-7052
GURENKO, A.O. ET AL.: "Synthesis of Novel Pyrazolo[3, 4-d] [1, 2, 3] Triazines", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 50, no. 4, 30 April 2014 (2014-04-30), XP055583638, ISSN: 0009-3122
CLARK, A.S. ET AL.: "Antitumor Imidazotetrazines. 32.1 Synthesis of Novel Imidazotetrazinones and Related Bicyclic Heterocycles to Probe the Mode of Action of the Antitumor Drug Temozolomide", J. MED. CHEM., vol. 38, no. 9, 30 April 1995 (1995-04-30), pages 1943 - 1504, XP001069007, ISSN: 0022-2623, DOI: doi:10.1021/jm00009a010
SRIVASTAVA, R. ET AL.: "Antithrombotic Effect of Thiopurinol", THROMBOSIS RESEARCH, vol. 54, no. 6, 15 June 1989 (1989-06-15), pages 741 - 749, XP026465095, ISSN: 0049-3848, DOI: doi:10.1016/0049-3848(89)90138-2
CHOI, J.H. ET AL.: "N-Glucosides of Fairy Chemicals, 2-Azahypoxanthine and 2-Aza-8- oxohypoxanthine, in Rice", ORG. LETT., vol. 20, no. 1, 13 December 2017 (2017-12-13), XP055583641, ISSN: 1523-7052
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