Title:
ANTI-TUMOR VACCINES DELIVERED BY DENDRITIC CELLS DEVOID OF INTERLEUKIN-10
Document Type and Number:
WIPO Patent Application WO2008071093
Kind Code:
A8
Abstract:
It has been discovered that reducing, inhibiting or preventing the expression of immunosuppressive cytokines or tolergenic agents in antigen presenting cells improves the ability of the antigen presenting cell to promote an immune response. One embodiment provides a genetically engineered antigen presenting cell that has reduced or no expression of IL-10. Preferred antigen presenting cells are dendritic cells. Expression of IL-10 can be inhibited or blocked by genetically engineering the antigen presenting cell to express inhibitory nucleic acids that inhibit or prevent the expression mRNA encoding immunosuppressive cytokines. Inhibitory nucleic acids include siRNA, antisense RNA, antisense DNA, microRNA, and enzymatic nucleic acids that target mRNA encoding immunosuppressive cytokines.
Inventors:
HUANG FANGPING (GB)
CHEN YUXIAO (CN)
MAN KWAN (CN)
CHEN YUXIAO (CN)
MAN KWAN (CN)
Application Number:
PCT/CN2007/003619
Publication Date:
October 30, 2008
Filing Date:
December 17, 2007
Export Citation:
Assignee:
UNIV HONG KONG (CN)
HUANG FANGPING (GB)
CHEN YUXIAO (CN)
MAN KWAN (CN)
HUANG FANGPING (GB)
CHEN YUXIAO (CN)
MAN KWAN (CN)
International Classes:
A61K39/00; A61K48/00; A61P35/04; C12N15/09; C12N15/11; C12N15/113
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