Title:
ANTI-ULCER COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2000/004891
Kind Code:
A2
Abstract:
A pharmaceutical composition for the prophylaxis or treatment of peptic ulcers includes a biocompatible anionic polysaccharide material containing glucuronic acid.
Inventors:
SANTAR IVAN (CZ)
KISS FRANTISEK (CZ)
BRIESTENSKY JIRI (CZ)
KISS FRANTISEK (CZ)
BRIESTENSKY JIRI (CZ)
Application Number:
PCT/IE1999/000068
Publication Date:
February 03, 2000
Filing Date:
July 21, 1999
Export Citation:
Assignee:
ALPENSTOCK HOLDINGS LTD (IE)
SANTAR IVAN (CZ)
KISS FRANTISEK (CZ)
BRIESTENSKY JIRI (CZ)
SANTAR IVAN (CZ)
KISS FRANTISEK (CZ)
BRIESTENSKY JIRI (CZ)
International Classes:
A01N43/04; A61K31/715; A61C8/00; A61K6/00; A61K6/898; A61K8/72; A61K8/96; A61K9/00; A61K9/02; A61K9/14; A61K9/16; A61K9/20; A61K9/22; A61K9/50; A61K9/52; A61K9/64; A61K9/70; A61K31/00; A61K31/4164; A61K31/70; A61K31/7048; A61K31/717; A61K31/718; A61K31/722; A61K31/74; A61K31/78; A61K31/785; A61K38/00; A61K38/16; A61K47/18; A61K47/32; A61K47/36; A61K47/38; A61K47/42; A61L15/16; A61L15/28; A61L27/00; A61P1/04; A61P3/06; A61P7/04; A61P11/00; A61P17/00; A61P31/04; A61P31/12; A61P35/00; C01D15/08; C08B15/00; C08B31/00; C08B37/00; C08J5/10; C08J9/00; C08L1/00; C08L3/00; C08L5/00; C08L89/00; C08B; (IPC1-7): A61K31/00
Domestic Patent References:
| WO1998033822A1 | 1998-08-06 | |||
| WO1998000180A1 | 1998-01-08 |
Foreign References:
| FR2167219A1 | 1973-08-24 | |||
| US5593682A | 1997-01-14 | |||
| US4728650A | 1988-03-01 | |||
| US5300493A | 1994-04-05 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 014, no. 531 (C-0780), 21 November 1990 (1990-11-21) & JP 02 221224 A (TATSUAKI YAMAGUCHI), 4 September 1990 (1990-09-04)
BRIESTENSKY J ET AL: "Production of oxidized cellulose-based sorbent as a resorbable hemostaic material" STN CHEMICAL ABSTRACTS, vol. 10, no. 110, 3 April 1989 (1989-04-03), XP002120226
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 01, 29 January 1999 (1999-01-29) & JP 10 287571 A (KAKEN PHARMACEUT CO LTD;TAKARA SHUZO CO LTD), 27 October 1998 (1998-10-27)
DOMSZY, J. G. ET AL: "Ionic interactions between chitosan and oxidized cellulose" CHITIN NAT. TECHNOL., ÄPROC. INT. CONF. CHITIN CHITOSANÜ, 3RD (1986), MEETING DATE 1985, 331-6. EDITOR(S): MUZZARELLI, RICCARDO A. A.;JEUNIAUX, CHARLES; GOODAY, GRAHAM W. PUBLISHER: PLENUM, NEW YORK, N. Y. , XP002121013
BRIESTENSKY J ET AL: "Production of oxidized cellulose-based sorbent as a resorbable hemostaic material" STN CHEMICAL ABSTRACTS, vol. 10, no. 110, 3 April 1989 (1989-04-03), XP002120226
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 01, 29 January 1999 (1999-01-29) & JP 10 287571 A (KAKEN PHARMACEUT CO LTD;TAKARA SHUZO CO LTD), 27 October 1998 (1998-10-27)
DOMSZY, J. G. ET AL: "Ionic interactions between chitosan and oxidized cellulose" CHITIN NAT. TECHNOL., ÄPROC. INT. CONF. CHITIN CHITOSANÜ, 3RD (1986), MEETING DATE 1985, 331-6. EDITOR(S): MUZZARELLI, RICCARDO A. A.;JEUNIAUX, CHARLES; GOODAY, GRAHAM W. PUBLISHER: PLENUM, NEW YORK, N. Y. , XP002121013
Attorney, Agent or Firm:
O'brien, John A. (County Dublin, IE)
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Claims:
CLAIMS
| 1. | A pharmaceutical composition for the prophylaxis or treatment of peptic ulcers including a biocompatible anionic polysaccharide material containing glucuronic acid. |
| 2. | A composition as claimed in claim 1 wherein the polysaccharide is derived from a starch, cellulose or gum, or is of microbial origin. |
| 3. | A composition as claimed in claim 1 or 2 wherein the polysaccharide material is polyanhydroglucuronic acid, biocompatible salts thereof, copolymers thereof and intermolecular polymer complexes thereof. |
| 4. | A composition as claimed in claim 3 wherein the biocompatible intermolecular polymer complex is a complex of an anionic component comprising a linear or branched polysaccharide chain containing glucuronic acid ; and a non protein cationic component comprising a linear or branched natural, semisynthetic or synthetic oligomer or polymer. |
| 5. | A composition as claimed in claim 4 wherein at least 5% of the basic structural units of the anionic component are glucuronic acid. |
| 6. | A composition as claimed in claims 4 or 5 wherein the cationic component contains nitrogen that either carries a positive charge or wherein the positive charge is induced by contact with the polysaccharidic anionic component. |
| 7. | A composition as claimed in claim 6 wherein the cationic component is selected from derivatives of acrylamide, methacrylamide and copolymers thereof. |
| 8. | A complex as claimed in claim 7 wherein the cationic component is selected from polyacrylamide, copolymer of hydroxyethylmethacrylate and hydroxypropylmetacrylamide, copolymers of acrylamide, butylacrylate, maleinanhydride and/or methylmetacrylate. |
| 9. | A composition as claimed in claim 4 wherein the cationic component is a cationised natural polysaccharide. |
| 10. | A composition as claimed in claim 9 wherein the polysaccharide is a starch, cellulose or gum. |
| 11. | A composition as claimed in claim 10 wherein the gum is guargumhydroxypropyltriammonium chloride. |
| 12. | A complex as claimed in claim 4 wherein the cationic component is a synthetic or semisynthetic polyamino acid. |
| 13. | A complex as claimed in claim 12 wherein the cationic component is polylysin, polyarginin, or a, (3poly [N (2hydroxyethyl) DLaspartamide]. |
| 14. | A complex as claimed in claim 4 wherein the cationic component is a synthetic antifibrinolytic. |
| 15. | A complex as claimed in claim 14 wherein the antifibrinolytic is a hexadimethrindibromide (polybren). |
| 16. | A composition as claimed in claim 4 wherein the cationic component is a natural or semisynthetic peptide. |
| 17. | A composition as claimed in claim 15 wherein the peptide is a protamine, gelatine, fibrinopeptide, or derivatives thereof. |
| 18. | A composition as claimed in claim 4 wherein the cationic component is an aminoglucane or derivatives thereof. |
| 19. | A composition as claimed in claim 18 wherein the aminoglucane is fractionated chitin or its deacetylated derivative chitosan. |
| 20. | A composition as claimed in claim 18 or 19 wherein the aminoglucane is of microbial origin or is isolated from the shells of arthropods such as crabs. |
| 21. | A composition as claimed in any of claims 4 to 20 wherein the anionic component is polyanhydroglucuronic acid [PAGA]. |
| 22. | A composition as claimed in any of claims 3 to 21 wherein the polyanhydroglucuronic acid and salts thereof contain in their polymeric chain from 8 to 30 per cent by weight of carboxyl groups, at least 80 per cent by weight of these groups being of the uronic type, at most 5 per cent by weight of carbonyl groups, and at most 0. 5 per cent by weight of bound nitrogen. |
| 23. | A composition as claimed in claim 22 wherein the polyanhydroglucuronic acid and salts thereof contain in their polymeric chain at most 0. 2 per cent by weight of bound nitrogen. |
| 24. | A composition as claimed in claim 22 or 23 wherein the molecular mass of the polymeric chain of the anionic component is from 1XI03 to 3xi05 Daltons. |
| 25. | A composition as claimed in claim 24 wherein the molecular mass of the polymeric chain of the anionic component ranges from 5x103 to 1.5 x 105 Daltons. |
| 26. | A composition as claimed in any of the claims 22 to 25 wherein the content of carboxyl groups is in the range of from 12 to 26 per cent by weight, at least 95 per cent of these groups being of the uronic type. |
| 27. | A composition as claimed in any of claims 22 to 26 wherein the anionic component contains at most 1 per cent by weight of carbonyl groups. |
| 28. | A composition as claimed in any of claims 22 to 27 wherein the carbonyl groups are intra and intermolecular 2, 6 and 3, 6 hemiacetals, 2, 4 hemialdals and C2C3 aldehydes. |
| 29. | A composition as claimed in claim 4 wherein the cationic component is gelatine. |
| 30. | A composition as claimed in claim 4 wherein the cationic component is chitosan. |
| 31. | A composition as claimed in claim 28 including at least one biocompatible biologically active substance. |
| 32. | A composition as claimed in claims 28 or 29 including at least one biologically acceptable adjuvant. |
| 33. | A composition as claimed in any preceding claim including at least one pharmaceutically active adjuvant. |
| 34. | A composition as claimed in claim 31 wherein the adjuvant is an antiulcer agent. |
| 35. | A composition as claimed in claim 32 therein the antiulcer agent is an antibiotic which is active against Helicobacter pylori. |
| 36. | A composition as claimed in claim 33 wherein the antibiotic is clarithyromycin. |
| 37. | A composition as claimed in claim 31 wherein the adjuvant is a H2 antagonist. |
| 38. | A composition as claimed in claim 35 wherein the adjuvant is cimetidine. |
| 39. | A composition as claimed in claim 31 wherein the adjuvant is a combination of an antibiotic which is active against Helicobacter pylori and a H2antagonist. |
| 40. | A composition as claimed in any of claims 31 to 39 including bismuth salt. |
| 41. | A composition as claimed in any preceding claim in a form for oral administration. |
| 42. | A composition as claimed in any preceding claim in the form of a tablet, pellet, capsule, granule, or microsphere. |
| 43. | A composition substantially as herein before described with reference to the examples. |
Description:
INTERNATIONALSEARCHREPORTApplication No PCT/IE99/00068 C.(Contfnuation)DOCUMENTSCONSIDEREDTOBERELEVANT CategoryCitationofdocument,withindication,whereappropriate,o
ftherelevantpassagesRelevanttodaim No. XFR2167219A(FAURELABORATOIRES)1-3 24August1973(1973-08-24) page1,line34-37 page2,line31-page4,line4 claims1-4 XBRIESTENSKYJETAL:"Productionof1-3 oxidizedcellulose-basedsorbentasa resorbablehemostaicmaterial" STNCHEMICALABSTRACTS, vol.10,no.110, 3April1989(1989-04-03),XP002120226 thewholedocument XUS5593682A(PAPASANDREASMETAL)1-3 14January1997(1997-01-14) claim1;examples1-10 P,XPATENTABSTRACTSOFJAPAN1-3 vol.1999,no.01, 29January1999(1999-01-29) &JP10287571A(KAKENPHARMACEUTCO LTD;TAKARASHUZOCOLTD), 27October1998(1998-10-27) abstract XUS4728650A(EZIRIKATSUSHIETAL)1-3 1March1988(1988-03-01) column58 example37 column20-24 AUS5300493A(ROMEOAURELIOETAL)1-3 5April1994(1994-04-05) claims1,16,17 ADOMSZY,J.G.ETAL:"Ionic interactions1-30 betweenchitosanandoxidizedcellulose" CHITINNAT.TECHNOL.,'PROC.INT.CONF. CHITINCHITOSAN!,3RD(1986),MEETINGDATE 1985,331-6.EDITOR(S):MUZZARELLI, RICCARDOA.A.;JEUNIAUX,CHARLES;GOODAY, GRAHAMW.PUBLISHER:PLENUM,NEWYORK,N. Y.,XP002121013 thewholedocument 1 INTERNATIONALSEARCH!----------------- ! International ApplicationNo Infonnatlon on patvnt 1amily membous PatentdocumentPublicationPatentfamilyPublication citedinsearchreportdate member (s)date JP02221224A04-09-1990NONE __________________--_-----___---_______-__-________T_-_ WO9833822A06-08-1998AU6004398A25-08-1998 GB2335921A06-10-1999 ZA9800783A17-08-1998 WO9800180A08-01-1998GB2314842A14-01-1998 AU3269297A21-01-1998 CA2258990A08-01-1998 CZ9804251A12-05-1999 EP0918548A02-06-1999 PL 330824 A 07-06-1999 PL 330824 A 07-06-1999 FR 2167219 A 24-08-1973 NONE US 5593682 A 14-01-1997 NONE JP10287571A 27-10-1998 NONE US4728650A01-03-1988JP1902888C08-02-1995 JP6031207B27-04-1994 JP61260077A18-11-1986 AT51400T15-04-1990 CA1286299A16-07-1991 EP0202580A26-11-1986 JP 62089676 A 24-04-1987 JP 62089676 A 24-04-1987 US5300493A05-04-1994IT1263755B29-08-1996 AU2548192A27-04-1993 WO9305792A01-04-1993 EP 0605478 A 13-07-1994 EP 0605478 A 13-07-1994