Title:
ANTI-VEGF A AND -VEGF C BISPECIFIC ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016516
Kind Code:
A1
Abstract:
A single-domain antibody polypeptide specifically binding to VEGF C and a construct thereof, an anti-VEGF C/VEGF A bispecific binding protein, polynucleotides encoding the polypeptide and protein, an expression vector, a host cell, a pharmaceutical composition thereof, and a method and use for treating diseases related to neovascularization.
Inventors:
LI YIMING (CN)
HU SIYI (CN)
CHEN BINGLIANG (CN)
ZHOU SHUAIXIANG (CN)
HU SIYI (CN)
CHEN BINGLIANG (CN)
ZHOU SHUAIXIANG (CN)
Application Number:
PCT/CN2022/111717
Publication Date:
February 16, 2023
Filing Date:
August 11, 2022
Export Citation:
Assignee:
INNOVENT BIOLOGICS SUZHOU CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; C07K16/22; C12N15/13
Domestic Patent References:
| WO1998045331A2 | 1998-10-15 |
Foreign References:
| US20130344072A1 | 2013-12-26 | |||
| US20150110787A1 | 2015-04-23 | |||
| US6403088B1 | 2002-06-11 | |||
| CN108640994A | 2018-10-12 | |||
| CN103842380A | 2014-06-04 | |||
| US20120207671A1 | 2012-08-16 | |||
| US20200308267A1 | 2020-10-01 | |||
| CN103562222A | 2014-02-05 |
Other References:
QASEMI MARYAM; BEHDANI MAHDI; SHOKRGOZAR MOHAMMAD ALI; MOLLA-KAZEMIHA VAHID; MOHSENI-KUCHESFAHANI HOMA; HABIBI-ANBOUHI MAHDI: "Construction and expression of an anti-VEGFR2 Nanobody-Fc fusionbody in NS0 host cell", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA., vol. 123, 1 January 1900 (1900-01-01), SAN DIEGO, CA. , pages 19 - 25, XP029536156, ISSN: 1046-5928, DOI: 10.1016/j.pep.2016.03.004
MORADI AZITA, POURSEIF MOHAMMAD M., JAFARI BEHZAD, PARVIZPOUR SEPIDEH, OMIDI YADOLLAH: "Nanobody-based therapeutics against colorectal cancer: Precision therapies based on the personal mutanome profile and tumor neoantigens", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 156, 1 June 2020 (2020-06-01), AMSTERDAM, NL, pages 1 - 15, XP055942121, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104790
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
NORTH ET AL.: "A New Clustering of Antibody CDR Loop Conformations", JOURNAL OF MOLECULAR BIOLOGY, vol. 406, 2011, pages 228 - 256, XP028129711, DOI: 10.1016/j.jmb.2010.10.030
"UniProt", Database accession no. P49767
YAZAKIWU: "Methods in Molecular Biology", vol. 248, 2003, HUMANA PRESS, pages: 255 - 268
J IMMUNOL METHODS., vol. 324, no. 1-2, 31 July 2007 (2007-07-31), pages 13 - 25
ESTEP, P. ET AL.: "High throughput solution Based measurement of antibody-antigen affinity and epitope binning", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
MORADI AZITA, POURSEIF MOHAMMAD M., JAFARI BEHZAD, PARVIZPOUR SEPIDEH, OMIDI YADOLLAH: "Nanobody-based therapeutics against colorectal cancer: Precision therapies based on the personal mutanome profile and tumor neoantigens", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 156, 1 June 2020 (2020-06-01), AMSTERDAM, NL, pages 1 - 15, XP055942121, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104790
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
NORTH ET AL.: "A New Clustering of Antibody CDR Loop Conformations", JOURNAL OF MOLECULAR BIOLOGY, vol. 406, 2011, pages 228 - 256, XP028129711, DOI: 10.1016/j.jmb.2010.10.030
"UniProt", Database accession no. P49767
YAZAKIWU: "Methods in Molecular Biology", vol. 248, 2003, HUMANA PRESS, pages: 255 - 268
J IMMUNOL METHODS., vol. 324, no. 1-2, 31 July 2007 (2007-07-31), pages 13 - 25
ESTEP, P. ET AL.: "High throughput solution Based measurement of antibody-antigen affinity and epitope binning", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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