Title:
ANTIBACTERIAL CHIRAL 8-(SUBSTITUTED PIPERIDINO)-BENZO [I, J] QUINOLIZINES, PROCESSES, COMPOSITIONS AND METHODS OF TREATMENT
Document Type and Number:
WIPO Patent Application WO2001085728
Kind Code:
A3
Abstract:
The present invention relates to optically pure 8-(substituted piperidino)-benzo [i,j] quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo [i,j] quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.
Inventors:
DE SOUZA NOEL JOHN (IN)
PATEL MAHESH VITHALBHAI (IN)
AGARWAL SHIV KUMAR (IN)
GUPTE SHRIKANT VINAYAK (IN)
UPADHYAY DILIP JATASHANKAR (IN)
BHAWSAR SATISH BALIRAM (IN)
JAFRI MOHAMMAD ALAM (IN)
KHORAKIWALA HABIL FAKHRUDDIN (IN)
PATEL MAHESH VITHALBHAI (IN)
AGARWAL SHIV KUMAR (IN)
GUPTE SHRIKANT VINAYAK (IN)
UPADHYAY DILIP JATASHANKAR (IN)
BHAWSAR SATISH BALIRAM (IN)
JAFRI MOHAMMAD ALAM (IN)
KHORAKIWALA HABIL FAKHRUDDIN (IN)
Application Number:
PCT/IN2001/000100
Publication Date:
September 12, 2002
Filing Date:
May 08, 2001
Export Citation:
Assignee:
DE SOUZA NOEL JOHN (IN)
PATEL MAHESH VITHALBHAI (IN)
AGARWAL SHIV KUMAR (IN)
GUPTE SHRIKANT VINAYAK (IN)
UPADHYAY DILIP JATASHANKAR (IN)
BHAWSAR SATISH BALIRAM (IN)
JAFRI MOHAMMAD ALAM (IN)
KHORAKIWALA HABIL FAKHRUDDIN (IN)
PATEL MAHESH VITHALBHAI (IN)
AGARWAL SHIV KUMAR (IN)
GUPTE SHRIKANT VINAYAK (IN)
UPADHYAY DILIP JATASHANKAR (IN)
BHAWSAR SATISH BALIRAM (IN)
JAFRI MOHAMMAD ALAM (IN)
KHORAKIWALA HABIL FAKHRUDDIN (IN)
International Classes:
C07C279/14; C07D455/04; (IPC1-7): C07D455/04; A61K31/4375; A61P31/04; C07F9/6561
Foreign References:
| US4399134A | 1983-08-16 |
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