Title:
ANTIBACTERIAL HEXAPEPTIDE FROM PEDIOCOCCUS ACIDILACTICI, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/035892
Kind Code:
A1
Abstract:
An antibacterial hexapeptide from pediococcus acidilactici and a preparation method therefor, relating to the field of bioengineering. An amino acid sequence of the antibacterial peptide lactein R16 is ENGEEE, the antibacterial peptide lactein R16 has good pH stability and good heat stability, has inhibiting effects on escherichia coli, listeria monocytogene and staphylococcus aureus, and can effectively reduce the number of escherichia coli in soybean meal. The antibacterial peptide lactein R16 has a certain proliferative effect on saccharomyces cerevisiae and lactobacillus plantarum, and has a certain removal capacity to hydrogen peroxide, hydroxyl radicals, DPPH free radicals and superoxide anions. The antibacterial peptide lactein R16 can be used for biological control, can be used as a feed additive and will play an important role in replacing antibiotics and resolving a feed safety problem in the future.
Inventors:
LU JIAN (CN)
CAI GUOLIN (CN)
WANG JUAN (CN)
ZHU DEWEI (CN)
CAI GUOLIN (CN)
WANG JUAN (CN)
ZHU DEWEI (CN)
Application Number:
PCT/CN2016/098420
Publication Date:
March 01, 2018
Filing Date:
September 08, 2016
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C07K7/06; A01N63/50; A23L3/3526
Domestic Patent References:
| WO2016044683A1 | 2016-03-24 |
Foreign References:
| CN105816912A | 2016-08-03 | |||
| US20140178353A1 | 2014-06-26 |
Other References:
WANG, PEIPEI: "Cloning and Sequence Analysis of Pedicoccus Acidilactici 16SrRNA Gene and Pediocin Gene", BASIC SCIENCES, CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 April 2009 (2009-04-15), pages 21 - 25
ZHU, SHUANG ET AL.: "Bacteriocins and Their Application in Animal Production", CHINESE JOURNAL OF ANIMAL NUTRITION, vol. 26, no. 2, 31 December 2014 (2014-12-31), pages 327 - 333
LOZANO, J. CN . ET AL.: "Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici", JOURNAL OF GENERAL MICROBIOLOGY, vol. 138, 31 December 1992 (1992-12-31), pages 1985 - 1990
HENDERSON, J.T. ET AL.: "Purification and Primary Structure of Pediocin PA-1 Produced by Pediococcus acidilactici PAC-1.0", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 295, no. 1, 15 May 1992 (1992-05-15), pages 5 - 12, XP024760474
ZHU, SHUANG ET AL.: "Bacteriocins and Their Application in Animal Production", CHINESE JOURNAL OF ANIMAL NUTRITION, vol. 26, no. 2, 31 December 2014 (2014-12-31), pages 327 - 333
LOZANO, J. CN . ET AL.: "Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici", JOURNAL OF GENERAL MICROBIOLOGY, vol. 138, 31 December 1992 (1992-12-31), pages 1985 - 1990
HENDERSON, J.T. ET AL.: "Purification and Primary Structure of Pediocin PA-1 Produced by Pediococcus acidilactici PAC-1.0", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 295, no. 1, 15 May 1992 (1992-05-15), pages 5 - 12, XP024760474
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)
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