Title:
ANTIBACTERIAL PEPTIDE CONSISTING OF TRANSMEMBRANE PEPTIDE DOMAIN AND BASIC OR POLAR AMINO ACIDS AT OPPOSITE ENDS THEREOF AND VARIANTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/049232
Kind Code:
A1
Abstract:
The present invention relates to a fusion polypeptide comprising a polypeptide containing a transmembrane domain (TMD) having the C-terminus and the N-terminus to which a polypeptide of general formula I is bound, and the fusion polypeptide can provide antibacterial activity against Gram-positive, Gram-negative, and multidrug-resistant bacteria.
Inventors:
LEE SO RA (KR)
YOO YOUNG DO (KR)
YOO YOUNG DO (KR)
Application Number:
PCT/KR2023/012962
Publication Date:
March 07, 2024
Filing Date:
August 31, 2023
Export Citation:
Assignee:
ANDANTE FM CO LTD (KR)
UNIV KOREA RES & BUS FOUND (KR)
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07K14/00; A01N37/46
Foreign References:
| KR20200144065A | 2020-12-28 |
Other References:
LEE JONG-KOOK, PARK YOONKYUNG: "Mechanism of Action of Antimicrobial Peptides Against Bacterial Membrane", JOURNAL OF BACTERIOLOGY AND VIROLOGY, KOREAN SOCIETY FOR MICROBIOLOGY, SEOUL, KR, vol. 44, no. 2, 1 June 2014 (2014-06-01), KR , pages 140 - 151, XP093145579, ISSN: 1598-2467, DOI: 10.4167/jbv.2014.44.2.140
DATABASE Protein 12 April 2022 (2022-04-12), ANONYMOUS: "HIG1 hypoxia inducible domain family member 1A [Homo sapiens]", XP093145586, retrieved from NCBI Database accession no. KAI2529107.1
YOU DEOK-GYUN, LEE HYE-RA, KIM HONG-KYU, LEE GI-YOUNG, YOO YOUNG-DO: "A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 15, 31 July 2021 (2021-07-31), Basel, CH , pages 8243, XP093109295, ISSN: 1422-0067, DOI: 10.3390/ijms22158243
PIRTSKHALAVA M, VISHNEPOLSKY B, GRIGOLAVA M: "Transmembrane and Antimicrobial Peptides. Hydrophobicity, Amphiphilicity and Propensity to Aggregation", ARXIV (CORNELL UNIVERSITY), CORNELL UNIVERSITY LIBRARY, ARXIV.ORG, ITHACA, 23 July 2013 (2013-07-23), Ithaca, XP093145588, Retrieved from the Internet [retrieved on 20240326], DOI: 10.48550/arxiv.1307.6160
DATABASE Protein 12 April 2022 (2022-04-12), ANONYMOUS: "HIG1 hypoxia inducible domain family member 1A [Homo sapiens]", XP093145586, retrieved from NCBI Database accession no. KAI2529107.1
YOU DEOK-GYUN, LEE HYE-RA, KIM HONG-KYU, LEE GI-YOUNG, YOO YOUNG-DO: "A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 15, 31 July 2021 (2021-07-31), Basel, CH , pages 8243, XP093109295, ISSN: 1422-0067, DOI: 10.3390/ijms22158243
PIRTSKHALAVA M, VISHNEPOLSKY B, GRIGOLAVA M: "Transmembrane and Antimicrobial Peptides. Hydrophobicity, Amphiphilicity and Propensity to Aggregation", ARXIV (CORNELL UNIVERSITY), CORNELL UNIVERSITY LIBRARY, ARXIV.ORG, ITHACA, 23 July 2013 (2013-07-23), Ithaca, XP093145588, Retrieved from the Internet
Attorney, Agent or Firm:
PARK, Hyuk (KR)
Download PDF: