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Title:
ANTIBACTERIAL PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/184399
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition that is effective against various β-lactamase-producing bacteria.　The present invention provides a pharmaceutical composition characterized by comprising a combination of (a) a compound represented by formula (I), or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt and (b) at least one component selected from the group consisting of: (i) ceftazidime, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt, and avibactam, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt; (ii)ceftolozane, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt, and tazobactam, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt; (iii) fosfomycin, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt; (iv) avibactam, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt, and pyridine 2,6-dicarboxylic acid, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt; (v) ampicillin, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt; and sulbactam, or a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the pharmaceutically acceptable salt.

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Inventors:
YAMANO YOSHINORI (JP)
TSUJI MASAKATSU (JP)
SATO TAKAFUMI (JP)
KOHIRA NAOKI (JP)
Application Number:
PCT/JP2020/009545
Publication Date:
September 17, 2020
Filing Date:
March 06, 2020
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
International Classes:
A61P31/04; A61K31/431; A61K31/439; A61K31/44; A61K31/546; A61K31/665; A61P43/00
Domestic Patent References:
WO2017216765A12017-12-21
WO2016035846A12016-03-10
WO2016035845A12016-03-10
WO2011125967A12011-10-13
WO2010050468A12010-05-06
WO2018060484A12018-04-05
Foreign References:
JP2002356427A2002-12-13
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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