Title:
ANTIBACTERIAL POLYPEPTIDE COMPOUND, MEDICAL INSTRUMENT, HYDROGEL, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143219
Kind Code:
A1
Abstract:
An antibacterial polypeptide compound, a medical instrument, a hydrogel, and an application thereof. The antibacterial polypeptide compound has high antibacterial activity, high enzymatic hydrolysis stability, high bioavailability, and low cytotoxicity. The hydrogel does not adhere to wounds, has antibacterial activity and a hemostatic effect, and can be used for the loading and slow release of drugs, for example, an anti-inflammatory drug, an epidermal growth factor, a vascular growth factor or the like can be loaded; moreover, the healing of wounds is accelerated, and the formation of scar tissue fiber is reduced. The preparation method for the hydrogel involves few processing steps and simple raw materials and is convenient to perform.
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Inventors:
LI YUE (CN)
Application Number:
PCT/CN2021/139094
Publication Date:
July 07, 2022
Filing Date:
December 17, 2021
Export Citation:
Assignee:
GUANGZHOU TOWE BIOTECH CO LTD (CN)
International Classes:
C07K7/06; A61K9/06; A61K38/08; A61K45/06; A61P17/02; A61P31/04
Foreign References:
| CN109456389A | 2019-03-12 | |||
| CN112121226A | 2020-12-25 | |||
| US20180086792A1 | 2018-03-29 |
Other References:
ZHOU JINGJING, ZHANG LISHI, HE YUHANG, LIU KEXIN, ZHANG FANGFANG, ZHANG HANRU, LU YAQI, YANG CHANGYAN, WANG ZHAOPENG, FAREED MUHAM: "An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 219, 1 July 2021 (2021-07-01), AMSTERDAM, NL , pages 1 - 13, XP055948997, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113433
MARTINS DANUBIA BATISTA; PACCA CAROLINA COLOMBELLI; DA SILVA ANNIELLE MENDES BRITO; DE SOUZA BIBIANA MONSON; DE ALMEIDA MARGARETE : "Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation", AMINO ACIDS, vol. 52, no. 5, 1 May 2020 (2020-05-01), AU , pages 725 - 741, XP037146554, ISSN: 0939-4451, DOI: 10.1007/s00726-020-02847-y
JIA FENGJING, ZHANG YI, WANG JIAYI, PENG JINXIU, ZHAO PING, ZHANG LISHI, YAO HAIYAN, NI JINGMAN, WANG KAIRONG: "The effect of halogenation on the antimicrobial activity, antibiofilm activity, cytotoxicity and proteolytic stability of the antimicrobial peptide Jelleine-I", PEPTIDES, vol. 112, 1 February 2019 (2019-02-01), AMSTERDAM, NL , pages 56 - 66, XP055948999, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2018.11.006
MARTINS DANUBIA BATISTA; PACCA CAROLINA COLOMBELLI; DA SILVA ANNIELLE MENDES BRITO; DE SOUZA BIBIANA MONSON; DE ALMEIDA MARGARETE : "Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation", AMINO ACIDS, vol. 52, no. 5, 1 May 2020 (2020-05-01), AU , pages 725 - 741, XP037146554, ISSN: 0939-4451, DOI: 10.1007/s00726-020-02847-y
JIA FENGJING, ZHANG YI, WANG JIAYI, PENG JINXIU, ZHAO PING, ZHANG LISHI, YAO HAIYAN, NI JINGMAN, WANG KAIRONG: "The effect of halogenation on the antimicrobial activity, antibiofilm activity, cytotoxicity and proteolytic stability of the antimicrobial peptide Jelleine-I", PEPTIDES, vol. 112, 1 February 2019 (2019-02-01), AMSTERDAM, NL , pages 56 - 66, XP055948999, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2018.11.006
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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