Title:
ANTIBACTERIAL SODIUM ALGINATE TISSUE ENGINEERING SCAFFOLD AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/179255
Kind Code:
A1
Abstract:
Disclosed are an antibacterial sodium alginate tissue engineering scaffold, a preparation method therefor and use thereof. The preparation method comprises the following steps: (1) preparing a biological ink comprising sodium alginate, amino glycoside antibiotics, and a solvent; (2) performing 3D printing processing molding on the biological ink to obtain an antibacterial sodium alginate tissue engineering scaffold precursor; and (3) activating the carboxyl group on sodium alginate in the antibacterial sodium alginate tissue engineering scaffold precursor, and amidating same with an amino group on amino glycoside antibiotics to generate a cross-link, so as to obtain the antibacterial sodium alginate tissue engineering scaffold. The antibacterial sodium alginate tissue engineering scaffold can slowly release amino glycoside antibiotics while being degraded, thereby achieving an antibacterial effect.
Inventors:
RUAN CHANGSHUN (CN)
HU CHENGSHEN (CN)
HU NAN (CN)
TANG LAN (CN)
ZHANG XINZHOU (CN)
HU CHENGSHEN (CN)
HU NAN (CN)
TANG LAN (CN)
ZHANG XINZHOU (CN)
Application Number:
PCT/CN2021/137747
Publication Date:
September 01, 2022
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
C08J3/24; A61L27/20; A61L27/54; A61L27/58; C08L5/04
Domestic Patent References:
| WO2016004216A2 | 2016-01-07 |
Foreign References:
| CN112898607A | 2021-06-04 | |||
| CN106421900A | 2017-02-22 | |||
| CN108721690A | 2018-11-02 | |||
| CN108567992A | 2018-09-25 | |||
| CN106822911A | 2017-06-13 |
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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