Title:
ANTIBODIES AGAINST DRUGS OF ABUSE
Document Type and Number:
WIPO Patent Application WO2004050032
Kind Code:
A3
Abstract:
The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man monoclonal antibodies directed to drugs of abuse. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FRI through FR3 or CDRl through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
Inventors:
OWENS SAMUEL M (US)
CARROLL FRANK I (US)
ABRAHAM PHILIP (US)
GUNNELL MELINDA G (US)
HAAK-FRENDSCHO MARY (US)
FENG XIAO (US)
CARROLL FRANK I (US)
ABRAHAM PHILIP (US)
GUNNELL MELINDA G (US)
HAAK-FRENDSCHO MARY (US)
FENG XIAO (US)
Application Number:
PCT/US2003/038384
Publication Date:
August 26, 2004
Filing Date:
December 02, 2003
Export Citation:
Assignee:
ABGENIX INC (US)
OWENS SAMUEL M (US)
CARROLL FRANK I (US)
ABRAHAM PHILIP (US)
GUNNELL MELINDA G (US)
HAAK-FRENDSCHO MARY (US)
FENG XIAO (US)
OWENS SAMUEL M (US)
CARROLL FRANK I (US)
ABRAHAM PHILIP (US)
GUNNELL MELINDA G (US)
HAAK-FRENDSCHO MARY (US)
FENG XIAO (US)
International Classes:
C07K16/44; (IPC1-7): A61K39/395
Foreign References:
| US20010051158A1 | 2001-12-13 |
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