ANTIBODIES BINDING LAG3 AND USES THEREOF - BEIJING MABWORKS BIOTECH CO LTD

Title:

ANTIBODIES BINDING LAG3 AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/243919

Kind Code:

A1

Abstract:

Provided is an isolated monoclonal antibody or an antigen-binding portion that specifically binding to human LAG3, a nucleic acid molecule, an expression vector, a host cell and a method for expressing the antibody or antigen-binding portion thereof. Further provided is an immuneconjugate, a bispecific molecule, a chimeric antigen receptor, and a pharmaceutical composition comprising the antibody or antigen-binding portion thereof thereof, as well as a treatment method using the same.

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Inventors:

HU WENQI (CN)
LI JIANGMEI (CN)
LI FENG (CN)

Application Number:

PCT/CN2020/120614

Publication Date:

December 09, 2021

Filing Date:

February 04, 2021

Export Citation:

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Assignee:

BEIJING MABWORKS BIOTECH CO LTD (CN)
BEIJING MABRIDGE BIOPHARMACEUTICAL CO LTD (CN)

International Classes:

C07K16/28; A61K38/20; A61K39/395; A61K45/06; A61P17/06; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/02; C07K14/725; C07K19/00; C12N15/13

Domestic Patent References:

WO2017087901A2	2017-05-26
WO2018208868A1	2018-11-15
WO2016028672A1	2016-02-25
WO2017015560A2	2017-01-26
WO2017062888A1	2017-04-13

Other References: