Title:
ANTIBODIES BINDING RANKL AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/115465
Kind Code:
A1
Abstract:
An isolated monoclonal antibody that specifically binds human RANKL, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or the antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. A treatment method using an anti-RANKL antibody or the antigen-binding portion is provided.
Inventors:
CHEN MINGJIU (CN)
ZHONG CATHY XIAOYAN (CN)
XIA SHUKAI (CN)
ZHONG CATHY XIAOYAN (CN)
XIA SHUKAI (CN)
Application Number:
PCT/CN2020/135970
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
BIOSION INC (CN)
International Classes:
A61K39/00; C07K16/00; A61K39/395; A61P7/06; C07K16/28; C07K16/44; C12N5/20; C12N15/09
Domestic Patent References:
| WO2010134507A1 | 2010-11-25 | |||
| WO2018223182A1 | 2018-12-13 | |||
| WO2012045481A2 | 2012-04-12 | |||
| WO2019080909A1 | 2019-05-02 |
Foreign References:
| EP3085709A1 | 2016-10-26 | |||
| CN103060274A | 2013-04-24 |
Other References:
DOUGALL WILLIAM C., ROMAN AGUILERA AMELIA, SMYTH MARK J.: "Dual targeting of RANKL and PD-1 with a bispecific antibody improves anti-tumor immunity", CLINICAL & TRANSLATIONAL IMMUNOLOGY, JOHN WILEY & SONS LTD, GB, vol. 8, no. 10, 1 January 2019 (2019-01-01), GB, XP055820188, ISSN: 2050-0068, DOI: 10.1002/cti2.1081
B. J. SCHMIEDEL, C. A. SCHEIBLE, T. NUEBLING, H.-G. KOPP, S. WIRTHS, M. AZUMA, P. SCHNEIDER, G. JUNG, L. GROSSE-HOVEST, H. R. SALI: "RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 73, no. 2, 15 January 2013 (2013-01-15), US, pages 683 - 694, XP055392588, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2280
DATABASE PROTEIN 10 March 2016 (2016-03-10), ANONYMOUS: "immunoglobulin heavy chain variable region, partial [Mus musculus]", XP055820191, retrieved from NCBI Database accession no. AML31476
B. J. SCHMIEDEL, C. A. SCHEIBLE, T. NUEBLING, H.-G. KOPP, S. WIRTHS, M. AZUMA, P. SCHNEIDER, G. JUNG, L. GROSSE-HOVEST, H. R. SALI: "RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 73, no. 2, 15 January 2013 (2013-01-15), US, pages 683 - 694, XP055392588, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2280
DATABASE PROTEIN 10 March 2016 (2016-03-10), ANONYMOUS: "immunoglobulin heavy chain variable region, partial [Mus musculus]", XP055820191, retrieved from NCBI Database accession no. AML31476
Attorney, Agent or Firm:
SHENZHEN SERMON PATENT FIRM (CN)
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