Title:
ANTIBODIES SPECIFICALLY RECOGNIZING PSEUDOMONAS PCRV AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/004446
Kind Code:
A1
Abstract:
Provided are antibodies including antigen-binding fragment thereof that specifically recognizing Pseudomonas PcrV. Also provided are methods of making and using these antibodies.
Inventors:
YU MAORONG (CN)
LI ZHONG (CN)
WANG CHAO (CN)
JIANG LIXIN (CN)
LI ZHONG (CN)
WANG CHAO (CN)
JIANG LIXIN (CN)
Application Number:
PCT/CN2020/100592
Publication Date:
January 14, 2021
Filing Date:
July 07, 2020
Export Citation:
Assignee:
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K16/12; A61P31/04
Domestic Patent References:
| WO2013128031A1 | 2013-09-06 | |||
| WO2013070615A1 | 2013-05-16 | |||
| WO2014074528A2 | 2014-05-15 |
Other References:
EVELYN DE TAVERNIER; LAURENT DETALLE; ERIKA MORIZZO; ANNELIES ROOBROUCK; SEVERINE DE TAEYE; MELANIE RIEGER; TOM VERHAEGHE; ANDREIA: "High Throughput Combinatorial Formatting of PcrV Nanobodies for Efficient Potency Improvement", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 29, 15 July 2016 (2016-07-15), pages 15243 - 15255, XP055376757, ISSN: 0021-9258, DOI: 10.1074/jbc.M115.684241
DARA W FRANK ,AMY VALLIS , JEANINE P WIENER-KRONISH , ARUP ROY-BURMA , EDWARD G SPACK , BRIAN P MULLANEY , MEHDI NEGDOUD , JAMES D: "Generation and Characterization of a Protective Monoclonal Antibody to Pseudomonas aeruginosa PcrV", THE JOURNAL OF INFECTIOUS DISEASES, vol. 186, no. 1, 1 July 2002 (2002-07-01), pages 64 - 73, XP008007095, ISSN: 0022-1899, DOI: 10.1086/341069
WARRENER P; VARKEY R; BONNELL J C; DIGIANDOMENICO A; CAMARA M; COOK K; PENG L; ZHA J; CHOWDURY P; SELLMAN B; STOVER C K: "A Novel Anti-PcrV Antibody Providing Enhanced Protection against Pseudomonas aeruginosa in Multiple Animal Infection Models", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, no. 8, 1 August 2014 (2014-08-01), pages 4384 - 4391, XP055242256, ISSN: 0066-4804, DOI: 10.1128/AAC.02643-14
See also references of EP 3997121A4
DARA W FRANK ,AMY VALLIS , JEANINE P WIENER-KRONISH , ARUP ROY-BURMA , EDWARD G SPACK , BRIAN P MULLANEY , MEHDI NEGDOUD , JAMES D: "Generation and Characterization of a Protective Monoclonal Antibody to Pseudomonas aeruginosa PcrV", THE JOURNAL OF INFECTIOUS DISEASES, vol. 186, no. 1, 1 July 2002 (2002-07-01), pages 64 - 73, XP008007095, ISSN: 0022-1899, DOI: 10.1086/341069
WARRENER P; VARKEY R; BONNELL J C; DIGIANDOMENICO A; CAMARA M; COOK K; PENG L; ZHA J; CHOWDURY P; SELLMAN B; STOVER C K: "A Novel Anti-PcrV Antibody Providing Enhanced Protection against Pseudomonas aeruginosa in Multiple Animal Infection Models", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, no. 8, 1 August 2014 (2014-08-01), pages 4384 - 4391, XP055242256, ISSN: 0066-4804, DOI: 10.1128/AAC.02643-14
See also references of EP 3997121A4
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