ANTIBODIES THAT TARGET HLA-E-HOST PEPTIDE COMPLEXES AND USES THEREOF

Title:

ANTIBODIES THAT TARGET HLA-E-HOST PEPTIDE COMPLEXES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/060893

Kind Code:

A8

Abstract:

Recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E-peptide complex, including HLA-E-VL9 complexes, and regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A ("NKG2A+"). Herein, monoclonal antibodies were recombinantly derived from isolated functional HLA-E-VL9-specific mAbs from HLA-E-VL9 peptide-immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity and can preferentially recognize HLA-E-VL9 peptide complexes expressed on the surface of tumor cells. The invention provides methods for using HLA-E-VL9 m Abs to modulate NK and/or CD8+T-cell function as part of immunotherapeutic strategies.

Inventors:

WATLTERS LUCY (GB)
GILLESPIE GERALDINE (GB)
BRACKENRIDGE SIMON (GB)
MCMICHAEL ANDREW (GB)
SAUNDERS KEVIN (US)
HAYNES BARTON (US)
LI DAPENG (US)
AZOITEI MIHAI (US)

Application Number:

PCT/US2021/050537

Publication Date:

May 05, 2022

Filing Date:

September 15, 2021

Export Citation:

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Assignee:

UNIV DUKE (US)
WATLTERS LUCY C (GB)
GILLESPIE GERALDINE (GB)
BRACKENRIDGE SIMON (GB)
MCMICHAEL ANDREW JAMES (GB)
SAUNDERS KEVIN O (US)

International Classes:

C07K16/28; A61K39/395; C07K14/705; C12P21/02

Attorney, Agent or Firm:

PETRUZZI, Heather et al. (US)

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