Title:
ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF THAT SPECIFICALLY RECOGNIZES B CELL MALIGNANCIES, CHIMERIC ANTIGEN RECEPTOR COMPRISING SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/125070
Kind Code:
A1
Abstract:
The present invention relates to: a novel antibody or an antigen-binding fragment thereof for use in the treatment of cancer by targeting B cell malignancies; a chimeric antigen receptor comprising the same; and uses thereof. The antibody of the present invention is an antibody specifically binding to CD19 highly expressed in cancer cells (particularly, blood cancer) and has very low homology compared to the CDR sequences of conventional CD19 target antibodies, and thus the sequence thereof is unique. In addition, cells expressing a chimeric antigen receptor comprising an anti-CD19 antibody or antigen-binding fragment of the present invention induce immune cell activity in response to a positive cell line expressing CD19, and thus can be usefully used as a therapeutic agent for CAR-immune cells.
More Like This:
| WO/2021/140222 | ANTI-CD40 ANTIBODIES AND COMPOSITIONS |
| WO/1995/025167 | ANTI-EGFR SINGLE-CHAIN FVS AND ANTI-EGFR ANTIBODIES |
| WO/2002/084286 | SCREENING METHOD |
Inventors:
LEE JONG SEO (KR)
KIM KYU TAE (KR)
KO BONG KOOK (KR)
KIM KI HYUN (KR)
KIM KYU TAE (KR)
KO BONG KOOK (KR)
KIM KI HYUN (KR)
Application Number:
PCT/KR2018/016515
Publication Date:
June 27, 2019
Filing Date:
December 21, 2018
Export Citation:
Assignee:
ABCLON INC (KR)
International Classes:
C07K16/28; A61K35/17; C07K14/725; C12N5/0783
Foreign References:
| US20050070693A1 | 2005-03-31 | |||
| KR20160037667A | 2016-04-06 | |||
| KR20110122859A | 2011-11-11 | |||
| KR20170178559A | 2017-12-22 | |||
| US4554101A | 1985-11-19 | |||
| US20160090427A1 | 2016-03-31 |
Other References:
DATABASE Protein 26 July 2016 (2016-07-26), "Immunoglobulin Heavy Chain Variable Region, Partial [Homo sapiens", XP055621246, retrieved from NCBI Database accession no. ACF37471.1
DATABASE Protein 21 June 2016 (2016-06-21), "Anti-HIV'-1 Immunoglobulin Light Chain Variable Region, Partial [Homo sapiens", XP055621253, retrieved from NCBI Database accession no. ALG00303.1
NICHOLSON ET AL., MOLECULAR IMMUNOLOGY, vol. 34, no. 6-17, 1997, pages 1157 - 1165
KOCHENDERFER ET AL., NATURE REVIEW CLINICAL ONCOL., vol. 10, no. 5, 2013, pages 267 - 276
PORTER ET AL., NEW ENG. J. MED., vol. 365, no. 8, 2011, pages 725 - 733
KALOS ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 95, 2011, pages 95ra73
KOCHENDERFER ET AL., BLOOD, vol. 116, no. 20, 2010, pages 4099 - 4102
KOCHENDERFER ET AL., BLOOD, vol. 119, no. 12, 2012, pages 2709 - 2720
KINDT ET AL.: "Kuby Immunology", 2007, W.H. FREEMAN AND CO., pages: 91
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Remington's Pharmaceutical Sciences", 1995
CARLOS BARBAS III ET AL.: "Phage display: a laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3730519A4
DATABASE Protein 21 June 2016 (2016-06-21), "Anti-HIV'-1 Immunoglobulin Light Chain Variable Region, Partial [Homo sapiens", XP055621253, retrieved from NCBI Database accession no. ALG00303.1
NICHOLSON ET AL., MOLECULAR IMMUNOLOGY, vol. 34, no. 6-17, 1997, pages 1157 - 1165
KOCHENDERFER ET AL., NATURE REVIEW CLINICAL ONCOL., vol. 10, no. 5, 2013, pages 267 - 276
PORTER ET AL., NEW ENG. J. MED., vol. 365, no. 8, 2011, pages 725 - 733
KALOS ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 95, 2011, pages 95ra73
KOCHENDERFER ET AL., BLOOD, vol. 116, no. 20, 2010, pages 4099 - 4102
KOCHENDERFER ET AL., BLOOD, vol. 119, no. 12, 2012, pages 2709 - 2720
KINDT ET AL.: "Kuby Immunology", 2007, W.H. FREEMAN AND CO., pages: 91
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Remington's Pharmaceutical Sciences", 1995
CARLOS BARBAS III ET AL.: "Phage display: a laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3730519A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
Download PDF: