Title:
ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF THAT TARGETS COTININE, CHIMERIC ANTIGEN RECEPTOR COMPRISING SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/171958
Kind Code:
A1
Abstract:
The present invention relates to an antibody or antigen-binding fragment thereof that targets cotinine, a chimeric antigen receptor comprising same, and uses thereof. The antibody of the present invention is an antibody that specifically binds to cotinine, and in particular, an antibody that binds more specifically to the S-isomer of cotinine than to the R-isomer thereof. In addition, the antibody has very low homology and a unique sequence, compared to the CDR sequences of conventional cotinine target antibodies. Cells expressing a chimeric antigen receptor comprising the anti-cotinine antibody or antigen-binding fragment of the present invention bind to a cotinine-conjugated switch and respond to a target cell line, thereby inducing immune cell activity. Therefore, the antibody or antigen-binding fragment thereof of the present invention can be used to suppress immune side effects due to overactivation of T cells through cotinine-mediated activation regulation of chimeric antigen receptor effector cells, and can be effectively used as a CAR-immune cell therapeutic agent.
Inventors:
LEE JONG-SEO (KR)
LEE YOUNG HA (KR)
LEE JONG-HO (KR)
KIM KI HYUN (KR)
LEE YOUNG HA (KR)
LEE JONG-HO (KR)
KIM KI HYUN (KR)
Application Number:
PCT/KR2023/002676
Publication Date:
September 14, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
ABCLON INC (KR)
International Classes:
C07K16/44; A61K35/17; A61K39/00; A61P37/00; C07K14/705; C07K14/725; C12N5/0783
Domestic Patent References:
| WO2019036419A1 | 2019-02-21 |
Foreign References:
| KR20210129318A | 2021-10-28 | |||
| KR20180031727A | 2018-03-28 | |||
| KR20180081010A | 2018-07-13 |
Other References:
BJERCKE R. J., ET AL.: "STEREOSPECIFIC MONOCLONAL ANTIBODIES TO NICOTINE AND COTININE AND THEIR USE IN ENZYME-LINKED IMMUNOSORBENT ASSAYS.", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, vol. 90, 1 January 1986 (1986-01-01), NL , pages 203 - 213, XP000916472, ISSN: 0022-1759, DOI: 10.1016/0022-1759(86)90077-3
Attorney, Agent or Firm:
KONG, Byung Wook (KR)
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