ANTIBODY-BASED CONSTRUCTS DIRECTED AGAINST TYROSINE KINASE RECEPTORS

Title:

ANTIBODY-BASED CONSTRUCTS DIRECTED AGAINST TYROSINE KINASE RECEPTORS

Document Type and Number:

WIPO Patent Application WO/2012/024659

Kind Code:

A9

Abstract:

The present invention features antibody-based constructs that include a combination of two or more of a tetrameric antibody, a single chain antibody, a diabody, a triabody, another immunoglobulin-based moiety, as described herein, or biologically active variants thereof.

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Inventors:

WITTRUP KARL DANE (US)
SPANGLER JAMIE B (US)
EPSTEIN BENJAMIN E (US)
ROSS BRIAN L (US)

Application Number:

PCT/US2011/048529

Publication Date:

December 20, 2012

Filing Date:

August 20, 2011

Export Citation:

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Assignee:

MASSACHUSETTS INST TECHNOLOGY (US)
WITTRUP KARL DANE (US)
SPANGLER JAMIE B (US)
EPSTEIN BENJAMIN E (US)
ROSS BRIAN L (US)

International Classes:

C07K16/28; A61K39/395; A61P35/00; C07K16/46; C12N15/13

Attorney, Agent or Firm:

MANDRAGOURAS, Amy E. et al. (One Post Office SquareBoston, MA, US)

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