Title:
ANTIBODY BINDING TO CHONDROITIN SULFATE PROTEOGLYCAN-5
Document Type and Number:
WIPO Patent Application WO/2020/004490
Kind Code:
A1
Abstract:
The present invention relates to: an antibody or a fragment of said antibody that binds to chondroitin sulfate proteoglycan-5 (CSPG5); a hybridoma that produces the antibody or the antibody fragment; a nucleic acid that contains a base sequence coding for the antibody or the antibody fragment; a transformed cell that contains a vector containing said nucleic acid; a method for manufacturing the antibody or the antibody fragment; a composition containing the antibody or the antibody fragment; a method for detecting or measuring an antigen present in the brain by employing the antibody or the antibody fragment; a method for diagnosing or treating a brain disease; a method for enhancing the retention of the antibody in the brain; a method for increasing the antibody quantity in the brain; and so forth.
More Like This:
| WO/2013/053021 | ANTIBODIES TO CD1d |
| JP7319348 | Bispecific anti-BCMA x anti-CD3 antibodies and their uses |
| JP2004041221 | MONOMER AND DIMER ANTIBODY FRAGMENT FUSION PROTEIN |
Inventors:
TAKAHASHI NOBUAKI (JP)
NAKANO RYOSUKE (JP)
MAEDA SAYAKA (JP)
ITO YUJI (JP)
NAKANO RYOSUKE (JP)
MAEDA SAYAKA (JP)
ITO YUJI (JP)
Application Number:
PCT/JP2019/025450
Publication Date:
January 02, 2020
Filing Date:
June 26, 2019
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
UNIV KAGOSHIMA (JP)
UNIV KAGOSHIMA (JP)
International Classes:
C12N15/13; A61K39/395; A61K47/56; A61K47/60; A61K47/68; A61K50/00; A61K51/10; A61P25/00; A61P29/00; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| WO2016175307A1 | 2016-11-03 | |||
| WO2012023623A2 | 2012-02-23 | |||
| WO2016081640A1 | 2016-05-26 | |||
| WO2016081643A1 | 2016-05-26 | |||
| WO2014033074A1 | 2014-03-06 | |||
| WO2016175307A1 | 2016-11-03 | |||
| WO2014054804A1 | 2014-04-10 | |||
| WO2011090754A1 | 2011-07-28 | |||
| WO2007048037A2 | 2007-04-26 | |||
| WO2012116927A1 | 2012-09-07 | |||
| WO2009131239A1 | 2009-10-29 | |||
| WO2001077342A1 | 2001-10-18 | |||
| WO2007024715A2 | 2007-03-01 | |||
| WO2009080251A1 | 2009-07-02 | |||
| WO2010151792A1 | 2010-12-29 | |||
| WO2006033386A1 | 2006-03-30 | |||
| WO2006075668A1 | 2006-07-20 | |||
| WO2011122011A2 | 2011-10-06 | |||
| WO2009125825A1 | 2009-10-15 | |||
| WO1997010354A1 | 1997-03-20 | |||
| WO2010143698A1 | 2010-12-16 | |||
| WO1994023021A1 | 1994-10-13 | |||
| WO2005035586A1 | 2005-04-21 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002088186A1 | 2002-11-07 |
Foreign References:
| JP2003079374A | 2003-03-18 | |||
| JPH09194502A | 1997-07-29 | |||
| CA2623841A1 | 2007-04-05 | |||
| US20070071675A1 | 2007-03-29 | |||
| JPS58110600A | 1983-07-01 | |||
| JPS60221091A | 1985-11-05 | |||
| US4686191A | 1987-08-11 | |||
| US4939094A | 1990-07-03 | |||
| US0160735A | 1875-03-09 | |||
| JPH0322979A | 1991-01-31 | |||
| JPH02227075A | 1990-09-10 | |||
| US6001358A | 1999-12-14 | |||
| JPS63299A | 1988-01-05 | |||
| JPH05336963A | 1993-12-21 | |||
| JPH02257891A | 1990-10-18 | |||
| US20070148165A1 | 2007-06-28 | |||
| US6737056B1 | 2004-05-18 | |||
| US7297775B2 | 2007-11-20 | |||
| US7317091B2 | 2008-01-08 | |||
| JP2013165716A | 2013-08-29 | |||
| JP2012021004A | 2012-02-02 | |||
| JP2018120476A | 2018-08-02 |
Other References:
WATANABE, E. ET AL.: "Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain", J. BIOL. CHEM., vol. 270, no. 45, 1995, pages 26876 - 26882, XP055326580, DOI: 10.1074/jbc.270.45.26876
AONO SACHIKO ,TOKITA YOSHIHITO, YASUDA YOKO, HIRANO KANAKO, YAMAUCHI SHINOBU, SHUO TAKUYA, MATSUI FUMIKO, KEINO HIROOMI, KASHIWAI : "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 83, no. 1, 1 January 2006 (2006-01-01), pages 110 - 118, XP055763205, ISSN: 0360-4012, DOI: 10.1002/jnr.20698
MASARU INATANI; HIDENOBU TANIHARA; ATSUHIKO OOHIRA; YASUMASA OTORI; AKIHIRO NISHIDA; MEGUMI HONJO; NORIAKI KIDO; YOSHIHITO HONDA: "Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 41, no. 13, 2000, pages 4338 - 4346, XP055763211, ISSN: 0146-0404
TAKUYA SHUO, SACHIKO AONO, KEIKO NAKANISHI, YOSHIHITO TOKITA, YOSHIYUKI KURODA, MICHIRU IDA, FUMIKO MATSUI, HIROYO MARUYAMA, TOSHI: "Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3- sensitive proteolysis", JOURNAL OF NEUROCHEMISTRY, vol. 102, no. 5, 15 September 2007 (2007-09-15), pages 1561 - 1568, XP055763216, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2007.04658.x
NOBUAKI TAKAHASHI, RINPEI NIWA , RYOUSUKE NAKANO , KAZUMA TOMIZUKA: "Strategy for technology development of antibody therapeutics", FOLIA PHARMACOLOGICA JAPONICA, vol. 147, no. 4, 1 January 2016 (2016-01-01), pages 235 - 240, XP055763221, ISSN: 0015-5691, DOI: 10.1254/fpj.147.235
KYLA RR.RICHARD CC., BIOTECHNOL ADV, vol. pii: S0734-9750, no. 16, 2016
PARDRIDGE WM., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1327 - 1338
WANG W. ET AL., CLIN. PHARMACOL. THER., vol. 84, 2008, pages 548 - 558
GARGA. ET AL., AAPSJ., vol. 11, 2009, pages 553 - 557
KAJ B. ET AL., ARCH. NEUROL., vol. 69, no. 8, 2012, pages 1002 - 1010
WRAITH JE. ET AL., J. PEDIATR., vol. 144, no. 5, 2004, pages 581 - 588
MUENZER J. ET AL., GENET MED, vol. 8, no. 8, 2006, pages 465 - 473
PACKAGE INSERT OF INTRAVENOUS INFUSION 2.9 MG OF ALDURAZYME, July 2016 (2016-07-01)
"Package insert of intravenous infusion 6 mg of Elaprase", July 2016
BROOKS, D. A. ET AL., TRENDS MOL. MED., vol. 9, 2003, pages 450 - 453
SORRENTINO NC. ET AL., PEDIATR ENDOCRINOL REV., vol. 1, 2016, pages 630 - 638
COUCH JA. ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 5, 2013, pages 183ra57
YU YJ. ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 6, 2014, pages 261ra154
NIEWOEHNER J. ET AL., NEURON, vol. 81, 2014, pages 49 - 60
JUN Y. ET AL., MACROMOL. BIOSCI., vol. 12, 2012, pages 1209 - 1219
PARDRIDGE WM.BOADO RJ., METHODS IN ENZYMOLOGY, vol. 503, pages 269 - 292
BOADO RJ. ET AL., DRUG METAB. DISPOS., vol. 37, no. 12, 2009, pages 2299 - 2304
BOADO RJ. ET AL., J. PHARMACOL. EXP. THER., vol. 333, no. 3, 2010, pages 961 - 969
BOADO RJ. ET AL., BIOCONJUGATE CHEM., vol. 1, 2012, pages 97 - 104
YUN ZHANG. ET AL., J. PHARMACOL. EXP. THER., vol. 313, no. 3, 2005, pages 1075 - 1081
ABULROB A. ET AL., J. NEUYROCHEM., vol. 95, no. 4, 2005, pages 1201 - 1214
FARRINGTON GK. ET AL., FASEB J., vol. 28, 2014, pages 4764 - 4778
WEBSTER CI. ET AL., FASEB J., vol. 30, 2016, pages 1927 - 1940
ZHANG Y. ET AL., J. NEUROIMMUNOL., vol. 114, no. 1-2, 2001, pages 168 - 172
PHILIP RC. ET AL., BRAIN RESEARCH, vol. 1534, 2013, pages 13 - 21
WATANABE E. ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 26876 - 26882
YASUDA Y. ET AL., NEUROSCI. RES., vol. 32, 1998, pages 313 - 322
AONO S. ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 337 - 342
SCHUMACHER S. ET AL., J. CELL BIOL., vol. 136, 1997, pages 895 - 906
INATANI M. ET AL., INVEST. OPHTHALMOL. VIS. SCI., vol. 41, 2000, pages 4338 - 46
JUTTNER R. ET AL., EUR. J. NEUROSCI., vol. 38, 2013, pages 3270 - 3280
SCHUMACHER S. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 7337 - 7345
SCHUMACHER S.STUBE E. M., J. NEUROCHEM., vol. 87, 2003, pages 1213 - 1223
KINUGASA Y. ET AL., BIOCHEM. BIOPH. RES. CO., vol. 321, 2004, pages 1045 - 1049
AONO S. ET AL., J. NEUROSCI. RES., vol. 83, 2006, pages 110 - 118
MARK A. ET AL., NATURE, vol. 532, 2016, pages 195 - 200
"NCBI", Database accession no. XM 015131074.1
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
CELL, vol. 41, 1985, pages 4431
"DNA Cloning 1: Core Techniques, A Practical Approach", 1995, OXFORD UNIVERSITY
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389
GENOME RES., vol. 7, 1997, pages 649, Retrieved from the Internet
RIDGWAY ET AL., PROTEIN ENGINEERING, vol. 9, no. 7, 1996, pages 617 - 621
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
TOMIZUKA K. ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722 - 7
WINTER G. ET AL., ANNU REV IMMUNOL, vol. 12, 1994, pages 433 - 55
ROSEN A. ET AL., NATURE, vol. 267, 1977, pages 52 - 54
WU ET AL., NATURE BIOTECHNOLOGY, vol. 25, no. 11, 2007, pages 1290 - 1297
LABRIJN ET AL., PNAS, vol. 110, no. 13, 2013, pages 5145 - 5150
KONTERMANN ET AL., MABS, vol. 4, 2012, pages 182 - 197
SPIESS ET AL., MOLECULAR IMMUNOLOGY, vol. 67, 2015, pages 95 - 106
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
KOLB, ANGEW CHEM INT ED ENGL, vol. 40, 2001, pages 2004 - 21
CLINICAL ONCOLOGY, JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, 1996
GENE, vol. 17, 1982, pages 107
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
NATURE, vol. 276, 1978, pages 269
JOURNAL OF EXPERIMENTAL MEDICINE, vol. 108, 1958, pages 945
PROC. NATL. ACAD. SCI. USA, vol. 60, 1968, pages 1275
GENETICS, vol. 55, 1968, pages 513
CHROMOSOMA, vol. 41, 1973, pages 129
METHODS IN CELL SCIENCE, vol. 18, 1996, pages 115
RADIATION RESEARCH, vol. 148, 1997, pages 260
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
CELL, vol. 6, 1975, pages 121
MOLECULAR CELL GENETICS, pages 883 - 900
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 18, 1978, pages 1
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
MIYAZAKI ET AL., J. BIOCHEM., vol. 158, no. 3, 2015, pages 205 - 215
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
CYTOTECHNOL., vol. 4, 1990, pages 173
CYTOTECHNOL., vol. 13, 1993, pages 79
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 33, 1983, pages 717
HYBRIDOMA, vol. 17, 1998, pages 559
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
STRATEGIES, vol. 5, 1992, pages 81
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
DNA CLONING: A PRACTICAL APPROACH, vol. 1, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENE, vol. 38, 1985, pages 275
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
"Methods in Nucleic Acids Res.", 1991, CRC PRESS, pages: 283
"Monoclonal Antibody Experimental Manual", 1987, KODANSHA SCIENTIFIC BOOKS
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
"Monoclonal Antibodies - Principles and Practice", 1996, ACADEMIC PRESS
NATURE, vol. 227, 1970, pages 680
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC., article "Immunologic studies in humans"
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Bioluminescence and Chemiluminescence", vol. 42, 1998, HIROKAWA-SHOTEN LTD., article "Clinical Test"
See also references of EP 3816291A4
AONO SACHIKO ,TOKITA YOSHIHITO, YASUDA YOKO, HIRANO KANAKO, YAMAUCHI SHINOBU, SHUO TAKUYA, MATSUI FUMIKO, KEINO HIROOMI, KASHIWAI : "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 83, no. 1, 1 January 2006 (2006-01-01), pages 110 - 118, XP055763205, ISSN: 0360-4012, DOI: 10.1002/jnr.20698
MASARU INATANI; HIDENOBU TANIHARA; ATSUHIKO OOHIRA; YASUMASA OTORI; AKIHIRO NISHIDA; MEGUMI HONJO; NORIAKI KIDO; YOSHIHITO HONDA: "Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 41, no. 13, 2000, pages 4338 - 4346, XP055763211, ISSN: 0146-0404
TAKUYA SHUO, SACHIKO AONO, KEIKO NAKANISHI, YOSHIHITO TOKITA, YOSHIYUKI KURODA, MICHIRU IDA, FUMIKO MATSUI, HIROYO MARUYAMA, TOSHI: "Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3- sensitive proteolysis", JOURNAL OF NEUROCHEMISTRY, vol. 102, no. 5, 15 September 2007 (2007-09-15), pages 1561 - 1568, XP055763216, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2007.04658.x
NOBUAKI TAKAHASHI, RINPEI NIWA , RYOUSUKE NAKANO , KAZUMA TOMIZUKA: "Strategy for technology development of antibody therapeutics", FOLIA PHARMACOLOGICA JAPONICA, vol. 147, no. 4, 1 January 2016 (2016-01-01), pages 235 - 240, XP055763221, ISSN: 0015-5691, DOI: 10.1254/fpj.147.235
KYLA RR.RICHARD CC., BIOTECHNOL ADV, vol. pii: S0734-9750, no. 16, 2016
PARDRIDGE WM., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1327 - 1338
WANG W. ET AL., CLIN. PHARMACOL. THER., vol. 84, 2008, pages 548 - 558
GARGA. ET AL., AAPSJ., vol. 11, 2009, pages 553 - 557
KAJ B. ET AL., ARCH. NEUROL., vol. 69, no. 8, 2012, pages 1002 - 1010
WRAITH JE. ET AL., J. PEDIATR., vol. 144, no. 5, 2004, pages 581 - 588
MUENZER J. ET AL., GENET MED, vol. 8, no. 8, 2006, pages 465 - 473
PACKAGE INSERT OF INTRAVENOUS INFUSION 2.9 MG OF ALDURAZYME, July 2016 (2016-07-01)
"Package insert of intravenous infusion 6 mg of Elaprase", July 2016
BROOKS, D. A. ET AL., TRENDS MOL. MED., vol. 9, 2003, pages 450 - 453
SORRENTINO NC. ET AL., PEDIATR ENDOCRINOL REV., vol. 1, 2016, pages 630 - 638
COUCH JA. ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 5, 2013, pages 183ra57
YU YJ. ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 6, 2014, pages 261ra154
NIEWOEHNER J. ET AL., NEURON, vol. 81, 2014, pages 49 - 60
JUN Y. ET AL., MACROMOL. BIOSCI., vol. 12, 2012, pages 1209 - 1219
PARDRIDGE WM.BOADO RJ., METHODS IN ENZYMOLOGY, vol. 503, pages 269 - 292
BOADO RJ. ET AL., DRUG METAB. DISPOS., vol. 37, no. 12, 2009, pages 2299 - 2304
BOADO RJ. ET AL., J. PHARMACOL. EXP. THER., vol. 333, no. 3, 2010, pages 961 - 969
BOADO RJ. ET AL., BIOCONJUGATE CHEM., vol. 1, 2012, pages 97 - 104
YUN ZHANG. ET AL., J. PHARMACOL. EXP. THER., vol. 313, no. 3, 2005, pages 1075 - 1081
ABULROB A. ET AL., J. NEUYROCHEM., vol. 95, no. 4, 2005, pages 1201 - 1214
FARRINGTON GK. ET AL., FASEB J., vol. 28, 2014, pages 4764 - 4778
WEBSTER CI. ET AL., FASEB J., vol. 30, 2016, pages 1927 - 1940
ZHANG Y. ET AL., J. NEUROIMMUNOL., vol. 114, no. 1-2, 2001, pages 168 - 172
PHILIP RC. ET AL., BRAIN RESEARCH, vol. 1534, 2013, pages 13 - 21
WATANABE E. ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 26876 - 26882
YASUDA Y. ET AL., NEUROSCI. RES., vol. 32, 1998, pages 313 - 322
AONO S. ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 337 - 342
SCHUMACHER S. ET AL., J. CELL BIOL., vol. 136, 1997, pages 895 - 906
INATANI M. ET AL., INVEST. OPHTHALMOL. VIS. SCI., vol. 41, 2000, pages 4338 - 46
JUTTNER R. ET AL., EUR. J. NEUROSCI., vol. 38, 2013, pages 3270 - 3280
SCHUMACHER S. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 7337 - 7345
SCHUMACHER S.STUBE E. M., J. NEUROCHEM., vol. 87, 2003, pages 1213 - 1223
KINUGASA Y. ET AL., BIOCHEM. BIOPH. RES. CO., vol. 321, 2004, pages 1045 - 1049
AONO S. ET AL., J. NEUROSCI. RES., vol. 83, 2006, pages 110 - 118
MARK A. ET AL., NATURE, vol. 532, 2016, pages 195 - 200
"NCBI", Database accession no. XM 015131074.1
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
CELL, vol. 41, 1985, pages 4431
"DNA Cloning 1: Core Techniques, A Practical Approach", 1995, OXFORD UNIVERSITY
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389
GENOME RES., vol. 7, 1997, pages 649, Retrieved from the Internet
RIDGWAY ET AL., PROTEIN ENGINEERING, vol. 9, no. 7, 1996, pages 617 - 621
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
TOMIZUKA K. ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722 - 7
WINTER G. ET AL., ANNU REV IMMUNOL, vol. 12, 1994, pages 433 - 55
ROSEN A. ET AL., NATURE, vol. 267, 1977, pages 52 - 54
WU ET AL., NATURE BIOTECHNOLOGY, vol. 25, no. 11, 2007, pages 1290 - 1297
LABRIJN ET AL., PNAS, vol. 110, no. 13, 2013, pages 5145 - 5150
KONTERMANN ET AL., MABS, vol. 4, 2012, pages 182 - 197
SPIESS ET AL., MOLECULAR IMMUNOLOGY, vol. 67, 2015, pages 95 - 106
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
KOLB, ANGEW CHEM INT ED ENGL, vol. 40, 2001, pages 2004 - 21
CLINICAL ONCOLOGY, JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, 1996
GENE, vol. 17, 1982, pages 107
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
NATURE, vol. 276, 1978, pages 269
JOURNAL OF EXPERIMENTAL MEDICINE, vol. 108, 1958, pages 945
PROC. NATL. ACAD. SCI. USA, vol. 60, 1968, pages 1275
GENETICS, vol. 55, 1968, pages 513
CHROMOSOMA, vol. 41, 1973, pages 129
METHODS IN CELL SCIENCE, vol. 18, 1996, pages 115
RADIATION RESEARCH, vol. 148, 1997, pages 260
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
CELL, vol. 6, 1975, pages 121
MOLECULAR CELL GENETICS, pages 883 - 900
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 18, 1978, pages 1
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
MIYAZAKI ET AL., J. BIOCHEM., vol. 158, no. 3, 2015, pages 205 - 215
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
CYTOTECHNOL., vol. 4, 1990, pages 173
CYTOTECHNOL., vol. 13, 1993, pages 79
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 33, 1983, pages 717
HYBRIDOMA, vol. 17, 1998, pages 559
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
STRATEGIES, vol. 5, 1992, pages 81
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
DNA CLONING: A PRACTICAL APPROACH, vol. 1, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENE, vol. 38, 1985, pages 275
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
"Methods in Nucleic Acids Res.", 1991, CRC PRESS, pages: 283
"Monoclonal Antibody Experimental Manual", 1987, KODANSHA SCIENTIFIC BOOKS
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
"Monoclonal Antibodies - Principles and Practice", 1996, ACADEMIC PRESS
NATURE, vol. 227, 1970, pages 680
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC., article "Immunologic studies in humans"
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Bioluminescence and Chemiluminescence", vol. 42, 1998, HIROKAWA-SHOTEN LTD., article "Clinical Test"
See also references of EP 3816291A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
Download PDF:
Previous Patent: COMMUNICATION SYSTEM AND COMMUNICATION METHOD
Next Patent: LIQUID PRODUCTION METHOD AND LIQUID PRODUCTION DEVICE
Next Patent: LIQUID PRODUCTION METHOD AND LIQUID PRODUCTION DEVICE