Title:
ANTIBODY BINDING TO FIBRIN, FIBRINOLYTIC PROTEIN CONTAINING ANTIBODY, AND PHARMACEUTICAL FORMULATION CONTAINING PROTEIN
Document Type and Number:
WIPO Patent Application WO/2023/195535
Kind Code:
A1
Abstract:
The present invention provides: a stable fibrin clot-soluble protein excellent in production in protein-expressing cells in a serum-free medium and suppressing the production of impurities such as degradation products; a pharmaceutical formulation containing the protein; and a production method for the protein and pharmaceutical formulation.
Inventors:
MATSUMURA YASUHIRO (JP)
HANAOKA SHINGO (JP)
HANAOKA SHINGO (JP)
Application Number:
PCT/JP2023/014377
Publication Date:
October 12, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
RIN INST INC (JP)
International Classes:
C12N15/62; A61K38/49; A61K39/395; A61K47/68; A61P7/02; A61P9/00; C07K14/745; C07K16/18; C07K19/00; C12N9/72; C12N15/13; C12N15/54; C12N15/58; C12P21/02
Domestic Patent References:
| WO2021200922A1 | 2021-10-07 | |||
| WO2018203517A1 | 2018-11-08 | |||
| WO2021200932A1 | 2021-10-07 |
Foreign References:
| JPS62272975A | 1987-11-27 | |||
| JPH0491792A | 1992-03-25 |
Other References:
QUAX PAUL H A; GRIMBERGEN JOS M; LANSINK MIRIAN; BAKKER ARJEN H F; BLATTER MARIE-CLAUDE; BELIN DOMINIQUE; VAN HINSBERGH VICTORW M;: "Binding of human urokinase-type plasminogen activator to its receptor: Residues involved in species specificity and binding", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 18, no. 5, 1 May 1998 (1998-05-01), pages 693 - 701, XP009154201, ISSN: 1079-5642, DOI: 10.1161/01.ATV.18.5.693
CHEN ZHUO, LIN LIN, HUAI QING, HUANG MINGDONG: "Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, BENTHAM SCIENCE PUBLISHERS, NL, vol. 12, no. 10, 1 December 2009 (2009-12-01), NL , pages 961 - 967, XP093097197, ISSN: 1386-2073, DOI: 10.2174/138620709789824727
CHEN ZHUO, LIN LIN, HUAI QING, HUANG MINGDONG: "Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, BENTHAM SCIENCE PUBLISHERS, NL, vol. 12, no. 10, 1 December 2009 (2009-12-01), NL , pages 961 - 967, XP093097197, ISSN: 1386-2073, DOI: 10.2174/138620709789824727
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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