Title:
ANTIBODY CONJUGATE AND APPLICATION OF PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/232638
Kind Code:
A1
Abstract:
An application of an antibody conjugate in the preparation of a drug for treating CD30 positive tumors, which is characterized in that: the antibody conjugate is F0002-ADC; the general formula of the structure thereof is Ab-Lm-Yn; and the CD30-positive tumors are CD30-positive tumors that express a multidrug resistance gene 1. In addition, a pharmaceutical combination and a pharmaceutical composition containing the antibody conjugate, which may be applied to the preparation of a drug used for treating CD30-positive tumors.
Inventors:
SHEN YIJUN (CN)
YANG TONG (CN)
LIU YANJUN (CN)
GUO QINGSONG (CN)
CAO XUEMEI (CN)
LI HUA (CN)
GAO BEI (CN)
WU GUANGHAO (CN)
MENG LIKAI (CN)
GAO YANBO (CN)
ZHU YANG (CN)
YANG TONG (CN)
LIU YANJUN (CN)
GUO QINGSONG (CN)
CAO XUEMEI (CN)
LI HUA (CN)
GAO BEI (CN)
WU GUANGHAO (CN)
MENG LIKAI (CN)
GAO YANBO (CN)
ZHU YANG (CN)
Application Number:
PCT/CN2019/087831
Publication Date:
November 26, 2020
Filing Date:
May 21, 2019
Export Citation:
Assignee:
SHANGHAI FUDAN ZHANGJIANG BIO PHARMACEUTICAL CO LTD (CN)
SHANGHAI JIAOLIAN MEDICINE RES AND DEVELOPMENT CO LTD (CN)
SHANGHAI JIAOLIAN MEDICINE RES AND DEVELOPMENT CO LTD (CN)
International Classes:
A61K47/68; A61K31/537; A61K47/54; A61P35/00
Foreign References:
| CN110075315A | 2019-08-02 | |||
| CN103596590A | 2014-02-19 | |||
| CN108883191A | 2018-11-23 | |||
| CN101087611A | 2007-12-12 |
Other References:
ZHU, GUIDONG ET AL.: "Design of next generation antibody drug conjugates", ACTA PHARMACEUTICA SINICA, vol. 48, no. 07, 31 July 2013 (2013-07-31), ISSN: 0513-4870, DOI: 9140302
MOHAMMAD, S. ET AL.: "Catabolism of antibody drug conjugates and characterization methods.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 25, no. 12, 11 April 2017 (2017-04-11), XP085030759, ISSN: 0968-0896, DOI: 20200228115735A
MOHAMMAD, S. ET AL.: "Catabolism of antibody drug conjugates and characterization methods.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 25, no. 12, 11 April 2017 (2017-04-11), XP085030759, ISSN: 0968-0896, DOI: 20200228115735A
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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