Title:
ANTIBODY-DRUG CONJUGATE COMPRISING APOLIPOPROTEIN
Document Type and Number:
WIPO Patent Application WO/2013/125769
Kind Code:
A1
Abstract:
The present invention relates to a mutant lipoprotein which can capture drugs and in which one or more amino acid residues of a hydrophilic region exposed outwardly from the lipoprotein during drug capture are substituted by cysteine. The present invention also relates to a nanostructure in which drugs are captured inside a three-dimensional structure of the mutant lipoprotein, to a method for producing the nanostructure, to an antibody-drug conjugate (ADC) in which the nanostructure and an antibody are conjugated, and to a method for producing the conjugate. The ADC of the present invention can be produced into a form in which a significantly larger number of drugs are conjugated to an antibody compared with conventional conjugates, thus achieving excellent treatment effects of drugs. Further, the ADC of the present invention may exhibit low treatment effects or low water solubility, but may exhibit excellent treatment effects when drugs are used with superior safety, thus improving treatment safety. The ADC of the present invention does not modify the chemical structures of drugs, thus preventing risks that might be caused by a drug modification. The ADC of the present invention does not cause a complex conjugation reaction, and therefore, can be widely used in the development of effective drug therapeutic agents.
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Inventors:
KWEON DAE HYUK (KR)
SHIN JAE YOON (KR)
SHIN JAE YOON (KR)
Application Number:
PCT/KR2012/009464
Publication Date:
August 29, 2013
Filing Date:
November 09, 2012
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN RES & BUS (KR)
International Classes:
C07K14/775; A61K9/10; A61K47/42; A61K47/48
Foreign References:
| US6897039B2 | 2005-05-24 |
Other References:
BURGESS, B. L. ET AL.: "A phospholipid-apolipoprotein A-1 nanoparticle containing amphotericin B as a drug delivery platform with cell membrane protective properties.", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 399, 7 August 2010 (2010-08-07), pages 148 - 155, XP027298466
NIKANJAM, M. ET AL.: "Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme.", JOURNAL OF CONTROLLED RELEASE, vol. 124, 2007, pages 163 - 171, XP022347965
ALLEN, T. M. ET AL.: "Therapeutic opportunities for targeted liposomal drug delivery.", ADVANCED DRUG DELIVERY REVIEWS, vol. 21, 1996, pages 117 - 133, XP055082417
NIKANJAM, M. ET AL.: "Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme.", JOURNAL OF CONTROLLED RELEASE, vol. 124, 2007, pages 163 - 171, XP022347965
ALLEN, T. M. ET AL.: "Therapeutic opportunities for targeted liposomal drug delivery.", ADVANCED DRUG DELIVERY REVIEWS, vol. 21, 1996, pages 117 - 133, XP055082417
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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Claims: