Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTIBODY-DRUG CONJUGATES AND PREPARATION METHODS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208216
Kind Code:
A1
Abstract:
Provided is an antibody-drug conjugate and its preparation methods and use, and specifically is an antibody-drug conjugate for treating HER3-positive cancers. Provided is a fully human HER3 antibody, which has excellent binding activity to HER3-positive cells and can efficiently deliver drugs to HER3-positive cells. Provided is a drug-linker molecule coupled to the antibody, and the drug comprises a DNA topoisomerase inhibitor. The obtained antibody-drug conjugate has a better drug-to-antibody ratio, and has a good targeted killing effect on colon cancer, gastric cancer, breast cancer, and lung cancer (e.g., non-small cell lung cancer, specifically, lung adenocarcinoma). Provided is a preparation method for the antibody-drug conjugate and application of the antibody-drug conjugate in the treatment of a HER3-positive cancer.

Inventors:
HU JIANGJIANG (CN)
TIAN QIANG (CN)
YUAN XIAOXI (CN)
WANG XIAOBEI (CN)
BAI YUN (CN)
LI LIRONG (CN)
LONG HU (CN)
ZHANG YITAO (CN)
ZHENG YONG (CN)
HU RUIBIN (CN)
PU YUZHI (CN)
HUANG XIUYING (CN)
SONG HONGMEI (CN)
Application Number:
PCT/CN2023/091744
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/68; A61P35/00; C07K16/28; C07K16/32
Domestic Patent References:
WO2022078425A12022-04-21
Foreign References:
US20220072144A12022-03-10
US20170035906A12017-02-09
US20190336615A12019-11-07
CN102633881A2012-08-15
CN102812045A2012-12-05
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: SECONDARY BATTERY TOP COVER AND SECONDARY BATTERY

Next Patent: POWER SUPPLY CONTROL SYSTEM AND POWER SUPPLY CONTROL METHOD