Title:
ANTIBODY FC REGION HAVING ENHANCED FCγRIIB AFFINITY
Document Type and Number:
WIPO Patent Application WO/2021/110110
Kind Code:
A1
Abstract:
Provided is a modified Fc region. The Fc region has at least one amino acid mutation with respect to a parent Fc region. The modified Fc region has improved affinity to FcγRIIB with respect to the affinity of the parent Fc region to FcγRIIB. Also provided is an antibody containing the modified Fc region, especially an agonistic antibody. The modified Fc region has significant use for optimizing the agonistic activity of the antibody.
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Inventors:
LI FUBIN (CN)
ZHANG YAN (CN)
ZHANG MI (CN)
BI YANXIA (CN)
TIAN SHIHAO (CN)
ZHANG HUIHUI (CN)
LIU SHUJUN (CN)
ZHANG YAN (CN)
ZHANG MI (CN)
BI YANXIA (CN)
TIAN SHIHAO (CN)
ZHANG HUIHUI (CN)
LIU SHUJUN (CN)
Application Number:
PCT/CN2020/133685
Publication Date:
June 10, 2021
Filing Date:
December 03, 2020
Export Citation:
Assignee:
SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
C07K16/00; A61K39/00
Domestic Patent References:
| WO2011120135A1 | 2011-10-06 | |||
| WO1998051793A1 | 1998-11-19 | |||
| WO1999037684A1 | 1999-07-29 |
Foreign References:
| CN101014619A | 2007-08-08 | |||
| CN1867583A | 2006-11-22 | |||
| US20090042291A1 | 2009-02-12 | |||
| CN2017087620W | 2017-06-08 | |||
| EP0988371A1 | 2000-03-29 | |||
| US20090042291A1 | 2009-02-12 |
Other References:
F. MIMOTO, H. KATADA, S. KADONO, T. IGAWA, T. KURAMOCHI, M. MURAOKA, Y. WADA, K. HARAYA, T. MIYAZAKI, K. HATTORI: "Engineered antibody Fc variant with selectively enhanced Fc�RIIb binding over both Fc�RIIaR131 and Fc�RIIaH131", PROTEIN ENGINEERING DESIGN AND SELECTION, IRL PRESS, vol. 26, no. 10, 1 October 2013 (2013-10-01), pages 589 - 598, XP055087986, ISSN: 17410126, DOI: 10.1093/protein/gzt022
CHU, S.Y. ; VOSTIAR, I. ; KARKI, S. ; MOORE, G.L. ; LAZAR, G.A. ; PONG, E. ; JOYCE, P.F. ; SZYMKOWSKI, D.E. ; DESJARLAIS, J.R.: "Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and Fc@cRIIb with Fc-engineered antibodies", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 15, 1 September 2008 (2008-09-01), GB, pages 3926 - 3933, XP023976264, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2008.06.027
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1992, GREENE PUBLISHING ASSOCIATES
HARLOWLANE: "Antibodies: A Laboratory Manual", 1990, COLD SPRING HARBOR LABORATORY PRESS
PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31
ADDGENE, PEAR ET AL., BLOOD, vol. 92, no. 10, 15 November 1998 (1998-11-15), pages 3780 - 92
RASMUS WERNERSSON, NUCL. ACIDS RES., vol. 34, 2006, pages W385 - W388, Retrieved from the Internet
SEUNG Y CHU ET AL., MOLECULAR IMMUNOLOGY, vol. 45, 2008, pages 3926 - 3933
F MIMOTO ET AL., PROTEIN ENGINEERING, DESIGN & SELECTION, vol. 26, no. 10, 2013, pages 589 - 598
See also references of EP 4071167A4
CHU, S.Y. ; VOSTIAR, I. ; KARKI, S. ; MOORE, G.L. ; LAZAR, G.A. ; PONG, E. ; JOYCE, P.F. ; SZYMKOWSKI, D.E. ; DESJARLAIS, J.R.: "Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and Fc@cRIIb with Fc-engineered antibodies", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 15, 1 September 2008 (2008-09-01), GB, pages 3926 - 3933, XP023976264, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2008.06.027
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1992, GREENE PUBLISHING ASSOCIATES
HARLOWLANE: "Antibodies: A Laboratory Manual", 1990, COLD SPRING HARBOR LABORATORY PRESS
PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31
ADDGENE, PEAR ET AL., BLOOD, vol. 92, no. 10, 15 November 1998 (1998-11-15), pages 3780 - 92
RASMUS WERNERSSON, NUCL. ACIDS RES., vol. 34, 2006, pages W385 - W388, Retrieved from the Internet
SEUNG Y CHU ET AL., MOLECULAR IMMUNOLOGY, vol. 45, 2008, pages 3926 - 3933
F MIMOTO ET AL., PROTEIN ENGINEERING, DESIGN & SELECTION, vol. 26, no. 10, 2013, pages 589 - 598
See also references of EP 4071167A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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