Title:
ANTIBODY FOR SPECIFICALLY RECOGNIZING LIGHT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067344
Kind Code:
A1
Abstract:
The present invention relates to an antibody or an antigen-binding fragment for specifically recognizing LIGHT, a preparation method therefor, and use thereof.
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Inventors:
ZHANG MIAOMIN (CN)
WANG GUOWU (CN)
YU DEBIN (CN)
CUI JINGLAN (CN)
WANG GUOWU (CN)
YU DEBIN (CN)
CUI JINGLAN (CN)
Application Number:
PCT/CN2023/120362
Publication Date:
April 04, 2024
Filing Date:
September 21, 2023
Export Citation:
Assignee:
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P11/00; A61P37/00; C12N15/13
Domestic Patent References:
| WO2008027338A2 | 2008-03-06 |
Foreign References:
| US20050129614A1 | 2005-06-16 | |||
| US20040096835A1 | 2004-05-20 |
Other References:
KEXING FAN: "Preparation and Characterization of a Monoclonal Antibody Against the Protein LIGHT", HYBRIDOMA, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 24, no. 6, 1 December 2005 (2005-12-01), US , pages 309 - 313, XP093153432, ISSN: 1554-0014, DOI: 10.1089/hyb.2005.24.309
MENG ZHANG; LAURENT PERRIN; PATRICIA PARDO: "A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti‐LIGHT Antibody, SAR252067", CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 6, no. 3, 28 September 2016 (2016-09-28), GB , pages 292 - 301, XP072461739, ISSN: 2160-763X, DOI: 10.1002/cpdd.295
TAMADA, K. ET AL.: "Modulation of T-Cell-Mediated Immunity in Tumor and Graft-Versus-Host Disease Models through the LIGHT Co-stimulatory Pathway.", NATURE MEDICINE, vol. 6, no. 3, 31 March 2000 (2000-03-31), XP002246831, DOI: 10.1038/73136
PERLIN, D.S. ET AL.: "Randomized, Double-Blind, Controlled Trial of Human Anti-LIGHT Monoclonal Antibody in COVID-19 Acute Respiratory Distress Syndrome.", THE JOURNAL OF CLINICAL INVESTIGATION., vol. 132, no. 3, 1 February 2022 (2022-02-01), XP093114353, DOI: 10.1172/JCI153173
MENG ZHANG; LAURENT PERRIN; PATRICIA PARDO: "A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti‐LIGHT Antibody, SAR252067", CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 6, no. 3, 28 September 2016 (2016-09-28), GB , pages 292 - 301, XP072461739, ISSN: 2160-763X, DOI: 10.1002/cpdd.295
TAMADA, K. ET AL.: "Modulation of T-Cell-Mediated Immunity in Tumor and Graft-Versus-Host Disease Models through the LIGHT Co-stimulatory Pathway.", NATURE MEDICINE, vol. 6, no. 3, 31 March 2000 (2000-03-31), XP002246831, DOI: 10.1038/73136
PERLIN, D.S. ET AL.: "Randomized, Double-Blind, Controlled Trial of Human Anti-LIGHT Monoclonal Antibody in COVID-19 Acute Respiratory Distress Syndrome.", THE JOURNAL OF CLINICAL INVESTIGATION., vol. 132, no. 3, 1 February 2022 (2022-02-01), XP093114353, DOI: 10.1172/JCI153173
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