Title:
ANTIBODY THAT RECOGNIZES NEOEPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/116423
Kind Code:
A1
Abstract:
In the present invention, prepared are a 9-10.2 antibody and an 8-4.1 antibody that recognize eight amino acids, YFGKLESK, present in the neoepitope formed as a result of a precursor pro-IL-18 being cleaved by caspase-1 or caspase-4. The present invention can provide antibodies that only recognize activated IL-18.
Inventors:
URANO TAKESHI (JP)
NARIAI YUKO (JP)
KAMINO HIROKI (JP)
OBAYASHI EIJI (JP)
NARIAI YUKO (JP)
KAMINO HIROKI (JP)
OBAYASHI EIJI (JP)
Application Number:
PCT/JP2019/047154
Publication Date:
June 11, 2020
Filing Date:
December 03, 2019
Export Citation:
Assignee:
MABPROTEIN CO LTD (JP)
International Classes:
A61K39/395; A61P29/00; A61P37/02; C07K16/24; C12N15/13; G01N33/53; G01N33/531; C12P21/08
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| WO2015032932A1 | 2015-03-12 | |||
| WO2014080866A1 | 2014-05-30 | |||
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Other References:
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KRUMM, B. ET AL., PLOS PATHOGENS, vol. 8, 2012, pages e1002876
MORIWAKI, YUJI ET AL.: "Elevated Levels of Interleukin-18 and Tumor Necrosis Factor-a in Serum of Patients With Type2 Diabetes Mellitus : Relationship With Diabetic Nephropathy, Metabolism", vol. 52, no. 5, May 2003 (2003-05-01), pages 605 - 608, XP055643064
AREND, W.P. ET AL., IMMUNOL. REV., vol. 223, 2008, pages 20 - 38
SANDERS, N.L.MISHRA, A., CYTOKINE GROWTH FACTOR REV., vol. 32, 2016, pages 31 - 39
HIREL, P-H. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 8247 - 8251
DALBOGE, H. ET AL., FEBS LETT., vol. 266, no. 1-2, 1990, pages 1 - 3
GIRARD, C. ET AL., RHEUMATOLOGY (OXFORD, vol. 55, no. 12, 2016, pages 2237 - 2247
OKAMURA, H. ET AL., NATURE, vol. 378, no. 6652, 1995, pages 88 - 91
KRUMM, B. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 105, 2008, pages 20711 - 20715
KRUMM, B. ET AL., PLOS PATHOGENS, vol. 8, 2012, pages e1002876
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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