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Title:
ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/124857
Kind Code:
A1
Abstract:
Provided are an antibody or an antigen-binding fragment thereof and the use thereof. The antibody or the antigen-binding fragment thereof contains a CDR sequence selected from at least one of the following: the CDR sequence of a heavy chain variable region as shown in SEQ ID NOs: 1-3 and the CDR sequence of a light chain variable region as shown in SEQ ID NOs: 4-6. The antibody can effectively bind to an α3 domain of MICCA or MICB, can further promote the binding of NKG2D to MICCA and/or MICB, can effectively treat or prevent MICCA and/or MICB-mediated diseases, and can promote the NK cells in killing tumors.

Inventors:
TIAN ZHIGANG (CN)
CAO GUOSHUAI (CN)
XIAO WEIHUA (CN)
SUN RUI (CN)
SUN HAOYU (CN)
Application Number:
PCT/CN2022/137233
Publication Date:
July 06, 2023
Filing Date:
December 07, 2022
Export Citation:
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Assignee:
HEFEI TG IMMUNOPHARMA CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61K47/68; A61P31/00; A61P35/00; A61P37/02; A61P37/06; C12N15/13; G01N33/574
Domestic Patent References:
WO2004037999A22004-05-06
WO2000055318A22000-09-21
WO2000078972A22000-12-28
WO1998049185A11998-11-05
Foreign References:
CN110088137A2019-08-02
CN112574311A2021-03-30
CN113637077A2021-11-12
CN112566659A2021-03-26
CN104244977A2014-12-24
CN108136015A2018-06-08
CN112673093A2021-04-16
CN202111629693A2021-12-28
EP0967284A11999-12-29
EP1085089A22001-03-21
GB2357768A2001-07-04
Other References:
LARRICK, J.W. ET AL., SCAND_J.IMMUNOL., vol. 32, 1990, pages 121 - 128
COLOMA, J.J. ET AL., BIOTECHNIQUES, vol. 11, 1991, pages 152 - 156
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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