Title:
ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2019/151320
Kind Code:
A1
Abstract:
The problem addressed by the present invention is to provide a technique for improving the anticancer effect of ubenimex, especially the anticancer effect on solid cancers. The problem is solved by a compound containing a chain-form structure obtained by linking a plurality of ubenimex to a chain-form polymer.
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Inventors:
MORI MASAKI (JP)
ISHII HIDESHI (JP)
KONNO MASAMITSU (JP)
EGUCHI HIDETOSHI (JP)
HARAGUCHI NAOTSUGU (JP)
TOSHIYAMA REISHI (JP)
NISHIYAMA NOBUHIRO (JP)
TAKEMOTO HIROYASU (JP)
ISHII HIDESHI (JP)
KONNO MASAMITSU (JP)
EGUCHI HIDETOSHI (JP)
HARAGUCHI NAOTSUGU (JP)
TOSHIYAMA REISHI (JP)
NISHIYAMA NOBUHIRO (JP)
TAKEMOTO HIROYASU (JP)
Application Number:
PCT/JP2019/003150
Publication Date:
August 08, 2019
Filing Date:
January 30, 2019
Export Citation:
Assignee:
UNIV OSAKA (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
C07K19/00; A61K31/198; A61K31/785; A61K45/00; A61K47/34; A61K47/42; A61K47/60; A61K47/64; A61P35/00; A61P43/00; C07K5/06; C07K14/81; C12N9/99; C12N9/64
Foreign References:
| JP2002515418A | 2002-05-28 | |||
| JP2017105800A | 2017-06-15 |
Other References:
YAMASHITA, MASAFUMI ET AL.: "A CD 13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 49, 2016, pages 89 - 98, XP055628479
ZHOU, ZHUXIAN ET AL.: "A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, 2015, pages 7594 - 7603, XP055628483
TOSHIYAMA, REISHI ET AL.: "Poly(ethylene glycol)- poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells", ONCOGENE, vol. 38, no. 2, August 2018 (2018-08-01), pages 244 - 260, XP036668959
YAMASHITA MWADA HEGUCHI HOGAWA HYAMADA DNODA T ET AL.: "A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma", INT J ONCOL, vol. 49, 2016, pages 89 - 98, XP055628479, DOI: 10.3892/ijo.2016.3496
ZHOU, ZHUXIAN ET AL.: "A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, 2015, pages 7594 - 7603, XP055628483
TOSHIYAMA, REISHI ET AL.: "Poly(ethylene glycol)- poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells", ONCOGENE, vol. 38, no. 2, August 2018 (2018-08-01), pages 244 - 260, XP036668959
YAMASHITA MWADA HEGUCHI HOGAWA HYAMADA DNODA T ET AL.: "A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma", INT J ONCOL, vol. 49, 2016, pages 89 - 98, XP055628479, DOI: 10.3892/ijo.2016.3496
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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