Title:
ANTICANCER DRUGS CONTAINING MICRORNAS AS ACTIVE INGREDIENTS, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2010/064762
Kind Code:
A1
Abstract:
The present invention relates to anticancer drugs containing microRNAs as active ingredients, and more particularly, to anticancer drugs containing miRNAs, to anticancer drugs containing miRNAs that inhibit the activity of p85α or Cdc42, and to anticancer drugs containing miRNAs that promote the activity of p53, as well as to a method for preparing same.
Inventors:
KIM VIC NARRY (KR)
LEE JUNG HYUN (KR)
PARK SUNG-YEON (KR)
LEE JUNG HYUN (KR)
PARK SUNG-YEON (KR)
Application Number:
PCT/KR2009/000414
Publication Date:
June 10, 2010
Filing Date:
January 28, 2009
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
KIM VIC NARRY (KR)
LEE JUNG HYUN (KR)
PARK SUNG-YEON (KR)
KIM VIC NARRY (KR)
LEE JUNG HYUN (KR)
PARK SUNG-YEON (KR)
International Classes:
A61K31/7105
Domestic Patent References:
| WO2008097277A2 | 2008-08-14 |
Other References:
PEKARSKY, Y ET AL.: "Tcll Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181", CANCER RESEARCH, vol. 66, no. 24, 15 December 2006 (2006-12-15), pages 11590 - 11593
FABBI, M. ET AL.: "MicroRNA-29 Family Reverts A berrant Methylation in Lung Cancer by Targeting DNA methyltransferases 3A and 3B", PNAS, vol. 104, no. 40, 2 October 2007 (2007-10-02), pages 15805 - 15810
MOTT, J. L. ET AL.: "miR-29 Regulates Mcl-1 Protein Expression and Apoptosis", ONCOGENE, vol. 26, no. 42, 2 April 2007 (2007-04-02), pages 6133 - 6140
WANG, H. ET AL.: "NF-kappaB-YYl-miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma.", CANCER CELL, vol. 14, no. 5, 4 November 2008 (2008-11-04), pages 369 - 381
FABBI, M. ET AL.: "MicroRNA-29 Family Reverts A berrant Methylation in Lung Cancer by Targeting DNA methyltransferases 3A and 3B", PNAS, vol. 104, no. 40, 2 October 2007 (2007-10-02), pages 15805 - 15810
MOTT, J. L. ET AL.: "miR-29 Regulates Mcl-1 Protein Expression and Apoptosis", ONCOGENE, vol. 26, no. 42, 2 April 2007 (2007-04-02), pages 6133 - 6140
WANG, H. ET AL.: "NF-kappaB-YYl-miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma.", CANCER CELL, vol. 14, no. 5, 4 November 2008 (2008-11-04), pages 369 - 381
Attorney, Agent or Firm:
LEE, WON-HEE (KR)
이원희 (KR)
이원희 (KR)
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