Title:
ANTICHOLINERGIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2022/111500
Kind Code:
A1
Abstract:
Compounds shown in Formula (I), pharmaceutical compositions, and methods of using related to muscarinic acetylcholine receptors. The compounds herein are typically muscarinic acetylcholine receptor antagonists, such as M 3 antagonists, which can be used for treating a variety of disorders, conditions or diseases such as hyperhidrosis.
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Inventors:
XIONG YUSHENG (CN)
GUAN HONGPING (CN)
GUAN HONGPING (CN)
Application Number:
PCT/CN2021/132671
Publication Date:
June 02, 2022
Filing Date:
November 24, 2021
Export Citation:
Assignee:
REZUBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D207/12; A61K31/40; A61P11/00; A61P17/00
Foreign References:
| US20180186735A1 | 2018-07-05 | |||
| US2956062A | 1960-10-11 | |||
| US3301869A | 1967-01-31 | |||
| US20020173536A1 | 2002-11-21 | |||
| CN106659697A | 2017-05-10 |
Other References:
DATABASE REGISTRY 21 December 2015 (2015-12-21), ANONYMOUS : "Piperidinium, 3-[[(2R)-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethyl-, (3S)- (CA INDEX NAME)", XP055937541, retrieved from STN Database accession no. 1834577-91-1
YAMASHITA， YASUNOBU ET AL.: "Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate，a muscarinic receptor antagonist with anti-inflammatory activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 8 June 2019 (2019-06-08), pages 3339 - 3346, XP085742175, DOI: 10.1016/j.bmc.2019.06.016
RYAN C. W., AINSWORTH C.: "The Synthesis and Anticholinergic Activity of Ester and Amide Derivatives of 2-Substituted Piperidines", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 26, no. 5, 1 May 1961 (1961-05-01), pages 1547 - 1550, XP055937544, ISSN: 0022-3263, DOI: 10.1021/jo01064a058
DOYLE F. P. ET AL.: "Pharmacodynamic compounds.Part I.Some antispasmodics derived from substituted 2-pyrrolidinylalkanols", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1958 (1958-12-31), pages 4458 - 4466, XP009142532, DOI: 10.1039/JR9580004458
YAMASHITA， YASUNOBU ET AL.: "Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate，a muscarinic receptor antagonist with anti-inflammatory activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 8 June 2019 (2019-06-08), pages 3339 - 3346, XP085742175, DOI: 10.1016/j.bmc.2019.06.016
RYAN C. W., AINSWORTH C.: "The Synthesis and Anticholinergic Activity of Ester and Amide Derivatives of 2-Substituted Piperidines", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 26, no. 5, 1 May 1961 (1961-05-01), pages 1547 - 1550, XP055937544, ISSN: 0022-3263, DOI: 10.1021/jo01064a058
DOYLE F. P. ET AL.: "Pharmacodynamic compounds.Part I.Some antispasmodics derived from substituted 2-pyrrolidinylalkanols", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1958 (1958-12-31), pages 4458 - 4466, XP009142532, DOI: 10.1039/JR9580004458
Attorney, Agent or Firm:
INNOPAT INTELLECTUAL PROPERTY CO., LTD. (CN)
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