Title:
ANTIGEN-BINDING MOLECULE CONTAINING ANTIGEN-BINDING DOMAIN OF WHICH BINDING ACTIVITY TO ANTIGEN IS CHANGED DEPENDING ON MTA, AND LIBRARY FOR OBTAINING SAID ANTIGEN-BINDING DOMAIN
Document Type and Number:
WIPO Patent Application WO/2020/189748
Kind Code:
A1
Abstract:
The present disclosure addresses the problem of providing: an antigen-binding molecule of which the antigen-binding activity is changed depending on the concentration of a low-molecular-weight compound specific to a target tissue; a polynucleotide encoding said antigen-binding molecule; a vector containing said polynucleotide; a cell carrying said vector; a library containing a plurality of said antigen-binding molecules that are different from each other; a pharmaceutical composition containing said antigen-binding molecule; a method for screening said antigen-binding molecule; and a method for producing the same. The inventors have found methylthioadenosine (MTA) to be a low-molecular-weight compound specific to a tumor tissue, have created an antigen-binding domain of which the binding activity to an antigen is changed depending on the concentration of MTA or created an antigen-binding molecule containing the antigen-binding domain, have further created a library containing a plurality of antigen-binding domains that are different from each other or an antigen-binding molecule containing the antigen-binding domains, and have found that the problem can be solved by using the library. By using an antigen-binding molecule according to the present disclosure, various diseases (for example, cancer) caused by a target tissue (for example, a tumor tissue) can be treated in a target tissue-specific manner.
Inventors:
MIZUNO HIDEAKI (JP)
SAKA KOICHIRO (JP)
KAWAUCHI HIROKI (JP)
KATO KUNIYASU (JP)
SAITO RYOICHI (JP)
IGAWA TOMOYUKI (SG)
OHARA KAZUHIRO (JP)
OKUDE JUNYA (JP)
SAKA KOICHIRO (JP)
KAWAUCHI HIROKI (JP)
KATO KUNIYASU (JP)
SAITO RYOICHI (JP)
IGAWA TOMOYUKI (SG)
OHARA KAZUHIRO (JP)
OKUDE JUNYA (JP)
Application Number:
PCT/JP2020/012189
Publication Date:
September 24, 2020
Filing Date:
March 19, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61P35/00; A61K39/395; C07K16/28; C07K16/44; C12N15/13; C12P21/08; C40B40/08; C40B40/10; G01N33/15; G01N33/53
Domestic Patent References:
| WO2015083764A1 | 2015-06-11 | |||
| WO2013180200A1 | 2013-12-05 | |||
| WO2004044011A2 | 2004-05-27 | |||
| WO2005040229A2 | 2005-05-06 | |||
| WO2002032925A2 | 2002-04-25 | |||
| WO1995001937A1 | 1995-01-19 | |||
| WO2002020565A2 | 2002-03-14 | |||
| WO2003029462A1 | 2003-04-10 | |||
| WO2008016854A2 | 2008-02-07 | |||
| WO1993011161A1 | 1993-06-10 | |||
| WO2015143414A2 | 2015-09-24 | |||
| WO2003000883A1 | 2003-01-03 | |||
| WO2004022754A1 | 2004-03-18 | |||
| WO2006006693A1 | 2006-01-19 | |||
| WO2003104453A1 | 2003-12-18 | |||
| WO1994011523A2 | 1994-05-26 | |||
| WO2013180200A1 | 2013-12-05 | |||
| WO1996034103A1 | 1996-10-31 | |||
| WO1999023221A2 | 1999-05-14 | |||
| WO1996027011A1 | 1996-09-06 | |||
| WO2006106905A1 | 2006-10-12 | |||
| WO2009086320A1 | 2009-07-09 | |||
| WO2008092117A2 | 2008-07-31 | |||
| WO2007041635A2 | 2007-04-12 | |||
| WO2006105338A2 | 2006-10-05 | |||
| WO2007024249A2 | 2007-03-01 | |||
| WO2007021841A2 | 2007-02-22 | |||
| WO2006031370A2 | 2006-03-23 | |||
| WO2000042072A2 | 2000-07-20 | |||
| WO2004029207A2 | 2004-04-08 | |||
| WO2004099249A2 | 2004-11-18 | |||
| WO2005070963A1 | 2005-08-04 | |||
| WO2006020114A2 | 2006-02-23 | |||
| WO2006116260A2 | 2006-11-02 | |||
| WO2006023403A2 | 2006-03-02 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2006067913A1 | 2006-06-29 | |||
| WO2002079255A1 | 2002-10-10 | |||
| WO2004065540A2 | 2004-08-05 | |||
| WO2002060919A2 | 2002-08-08 | |||
| WO2004035752A2 | 2004-04-29 | |||
| WO2011122011A2 | 2011-10-06 | |||
| WO2012133782A1 | 2012-10-04 | |||
| WO2012115241A1 | 2012-08-30 | |||
| WO2013125667A1 | 2013-08-29 | |||
| WO2013002362A1 | 2013-01-03 | |||
| WO2013046704A2 | 2013-04-04 | |||
| WO2009125825A1 | 2009-10-15 | |||
| WO2012073992A1 | 2012-06-07 | |||
| WO2009140242A1 | 2009-11-19 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1993012227A1 | 1993-06-24 | |||
| WO1992003918A1 | 1992-03-19 | |||
| WO1994002602A1 | 1994-02-03 | |||
| WO1994025585A1 | 1994-11-10 | |||
| WO1996034096A1 | 1996-10-31 | |||
| WO1996033735A1 | 1996-10-31 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
| WO1993019172A1 | 1993-09-30 | |||
| WO1995001438A1 | 1995-01-12 | |||
| WO1995015388A1 | 1995-06-08 | |||
| WO2015046554A1 | 2015-04-02 | |||
| WO1996000257A1 | 1996-01-04 |
Foreign References:
| JP2007531724A | 2007-11-08 | |||
| JP2018537473A | 2018-12-20 | |||
| EP0404097A2 | 1990-12-27 | |||
| US6248516B1 | 2001-06-19 | |||
| US20110123527A1 | 2011-05-26 | |||
| US20090136485A1 | 2009-05-28 | |||
| JP2012054624W | 2012-02-24 | |||
| JP2012058603W | 2012-03-30 | |||
| US4816567A | 1989-03-28 | |||
| US5648237A | 1997-07-15 | |||
| US5789199A | 1998-08-04 | |||
| US5840523A | 1998-11-24 | |||
| US5959177A | 1999-09-28 | |||
| US6040498A | 2000-03-21 | |||
| US6420548B1 | 2002-07-16 | |||
| US7125978B1 | 2006-10-24 | |||
| US6417429B1 | 2002-07-09 | |||
| EP0239400A2 | 1987-09-30 | |||
| US4737456A | 1988-04-12 |
Other References:
ENOMOTO K. ET AL.: "Development of high-throughput spermidine synthase activity assay using homogeneous time-resolved fluorescence", ANALYTICAL BIOCHEMISTRY, vol. 351, 2006, pages 229 - 240, XP024942404, DOI: 10.1016/j.ab.2006.01.012
STEVENS A. P. ET AL.: "Quantitative analysis of 5'-deoxy-5'- methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY B, vol. 876, 2008, pages 123 - 128, XP025681507, DOI: 10.1016/j.jchromb.2008.10.038
KATHARINA LIMM, WALLNER SUSANNE, MILENKOVIC VLADIMIR M., WETZEL CHRISTIAN H., BOSSERHOFF ANJA-KATRIN: "The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma", EUROPEAN JOURNAL OF CANCER, vol. 50, no. 15, 30 July 2014 (2014-07-30) - October 2014 (2014-10-01), pages 2714 - 2724, XP055741192
JANICE M REICHERTCLARK J ROSENSWEIGLAURA B FADENMATTHEW C DEWITZ: "Monoclonal antibody successes in the clinic", NAT. BIOTECHNOL., vol. 23, 2005, pages 1073 - 1078, XP002555770, DOI: 10.1038/nbt0905-1073
PAVLOU AKBELSEY MJ.: "The therapeutic antibodies market to 2008", EUR. J. PHARM. BIOPHARM., vol. 59, no. 3, 2005, pages 389 - 396, XP025317626, DOI: 10.1016/j.ejpb.2004.11.007
WEINER LMSURANA RWANG S.: "Monoclonal antibodies: versatile platforms for cancer immunotherapy", NAT. REV. IMMUNOL., vol. 10, no. 5, 2010, pages 317 - 327, XP055217481, DOI: 10.1038/nri2744
LEWIS GDFIGARI IFENDLY BWONG WLCARTER PGORMAN CSHEPARD HM: "Differential responses of human tumor cell lines to anti-pl85HER2 monoclonal antibodies", CANCER IMMUNOL. IMMUNOTHERAPY, vol. 37, 1993, pages 255 - 263, XP002961547, DOI: 10.1007/BF01518520
SATOH MIIDA SSHITARA K.: "Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies", EXPERT OPIN. BIOL. THER., vol. 6, no. 11, 2006, pages 1161 - 1173, XP008078583, DOI: 10.1517/14712598.6.11.1161
DESJARLAIS JRLAZAR GAZHUKOVSKY EACHU SY.: "Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective", DRUG DISCOV. TODAY, vol. 12, 2007, pages 898 - 910, XP022338218, DOI: 10.1016/j.drudis.2007.08.009
ALLEY SCOKELEY NMSENTER PD.: "Antibody-drug conjugates: targeted drug delivery for cancer", CURR. OPIN. CHEM. BIOL., vol. 14, no. 4, 2010, pages 529 - 537, XP055042125, DOI: 10.1016/j.cbpa.2010.06.170
BAEUERLE PAKUFER PBARGOU R.: "BiTE: Teaching antibodies to engage T-cells for cancer therapy", CURR. OPIN. MOL. THER., vol. 11, no. 1, 2009, pages 22 - 30, XP009151509
LUTTERBUESE RRAUM TKISCHEL RHOFFMANN PMANGOLD SRATTEL BFRIEDRICH MTHOMAS OLORENCZEWSKI GRAU D: "T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells", PROC. NATL. ACAD. SCI. U.S.A., vol. 107, no. 28, 2010, pages 12605 - 12610, XP055067703, DOI: 10.1073/pnas.1000976107
RIECHELMANN HSAUTER AGOLZE WHANFT GSCHROEN CHOERMANN KERHARDT TGRONAU S: "Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma", ORAL ONCOL, vol. 44, no. 9, 2008, pages 823 - 829, XP024341160, DOI: 10.1016/j.oraloncology.2007.10.009
TRINH VAHWU WJ.: "Ipilimumab in the treatment of melanoma", EXPERT OPIN. BIOL. THER., 2012
KIM SJPARK YHONG HJ.: "Antibody engineering for the development of therapeutic antibodies", MOL. CELLS., vol. 20, no. 1, 2005, pages 17 - 29
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. U.S.A., vol. 100, no. 11, 2003, pages 6353 - 6357
CO, M. S. ET AL., J. IMMUNOL., vol. 152, no. 10, 1994, pages 2968 - 2976
NAT. MED., vol. 13, 2007, pages 851 - 856
PORTOLANO ET AL., J. IMMUNOL., vol. 150, 1993, pages 880 - 887
CLARKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
CHOTHIA AND LESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
BIRD ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
PLUECKTHUN AND SKERRA, METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
HUSTON ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, no. 23, 1988, pages 8998 - 9002
HUDSON ET AL., J. IMMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
BETTER, M.HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E.WALKER, B. W., BIOTECHNOL, vol. 9, 1991, pages 132 - 137
C VINCKE ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, pages 3273 - 3284
METHODS IN MOLECULAR BIOLOGY, vol. 911, 2012, pages 65 - 78
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1764, no. 8, 2006, pages 1307 - 1319
JOURNAL OF APPLIED MICROBIOLOGY, vol. 117, no. 2, 2014, pages 528 - 536
JOURNAL OF BIOMOLECULAR SCREENING, vol. 21, no. 1, 2016, pages 35 - 43
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 24, 2016, pages 12641 - 12657
AIDS, vol. 30, no. 11, 2016, pages 1691 - 1701
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
J. IMMUNOL. METHODS, vol. 35, no. 1-2, 1980, pages 1 - 21
J. EXP. MED., vol. 148, no. 1, 1978, pages 313 - 323
NATURE, vol. 277, no. 5692, 1979, pages 131 - 133
KOHLERMILSTEIN ET AL., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
CURRENT PROTOCOLS IN PROTEIN SCIENCE, May 2001 (2001-05-01)
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CONRATH ET AL., J. BIOL. CHEM., vol. 276, no. 10, 2001, pages 7346 - 7350
MUYLDERMANS, REV. MOL. BIOTECH., vol. 74, 2001, pages 277 - 302
MILSTEIN ET AL., NATURE, vol. 305, 1983, pages 537 - 540
HOLLIGER ET AL., PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
MERCHANT ET AL., NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681
STEVENS ET AL., J CHROMATOGR A., vol. 1217, no. 19, 7 May 2010 (2010-05-07), pages 3282 - 8
EVA GOTTFRIEDKATRIN PETERMARINA P. KREUTZ, FROM MOLECULAR TO MODULAR TUMOR THERAPY, vol. 3, no. 2, 2010, pages 111 - 132
DHANASEKARAN ET AL., NATURE, vol. 412, 2001, pages 822 - 826
LAPOINTE ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 101, 2004, pages 811 - 816
PEROU ET AL., NATURE, vol. 406, 2000, pages 747 - 752
AHRAM ET AL., MOL. CARCINOG., vol. 33, 2002, pages 9 - 15
HOOD ET AL., MOL. CELL. PROTEOMICS, vol. 4, 2005, pages 1741 - 1753
BRINDLE ET AL., J. MOL. RECOGNIT., vol. 10, 1997, pages 182 - 187
GATESSWEELEY, CLIN. CHEM., vol. 24, 1978, pages 1663 - 1673
DANGSEMENZA, TRENDS BIOCHEM. SCI., vol. 24, 1999, pages 68 - 72
VIZAN ET AL., CANCER RES., vol. 65, 2005, pages 5512 - 5515
LAWTON ET AL., PHARMACOGENOMICS, vol. 9, 2008, pages 383
DESMOULIN F ET AL., DRUG METAB DISPOS, 2002
DUAN JX ET AL., J MED CHEM., 2008
CHRISTOFK ET AL., NATURE, vol. 452, 2008, pages 230 - 233
FANTIN ET AL., CANCER CELL, vol. 9, 2006, pages 425 - 434
TERESA ET AL., MOL. CANCER, vol. 8, 2009, pages 41 - 59
NATURE IMMUNOLOGY, vol. 9, 2008, pages 1261 - 1269
MAZUREKEIGENBRODT, ANTICANCER RES, vol. 23, 2003, pages 1149 - 1154
MAZUREK ET AL., J. CELL. PHYSIOL., vol. 181, 1999, pages 136 - 146
DROGE, IMMUNOBIOLOGY, vol. 174, 1987, pages 473 - 479
UYTTENHOVE ET AL., NAT. MED., vol. 9, 2003, pages 1269 - 127
LOB ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 58, 2009, pages 153 - 157
OPITZ ET AL., NATURE, vol. 478, no. 7368, 2011, pages 197 - 203
J. IMMUNOL., vol. 181, 2008, pages 5396 - 5404
YU ET AL., J. IMMUNOL., vol. 190, 2013, pages 3783 - 3797
FRUMENTO ET AL., J. EXP. MED., vol. 196, 2002, pages 459 - 468
WARNERMITCHELL, FASEB J, vol. 18, 2004, pages 790 - 804
SHENG ET AL., CANCER RES., vol. 58, 1998, pages 362 - 366
DENKERT ET AL., CLIN. BREAST CANCER, vol. 4, 2004, pages 428 - 433
DENKER ET AL., MOD. PATHOL., vol. 19, 2006, pages 1261 - 1269
CURR. MED. CHEM., vol. 18, 2011, pages 5217 - 5223
NAT. REV. CANCER, vol. 12, no. 11, 2012, pages 782 - 792
J. LAB. CLIN. MED., vol. 122, 1993, pages 518 - 523
EUR. J. CLIN. PHARMACOL., vol. 46, 1994, pages 3 - 7
CLIN. EXP. RHEUMATOL., vol. 17, 1999, pages 151 - 160
AM. J. VET. RES., vol. 65, 2004, pages 1269 - 1275
PLOS ONE, vol. 3, 2008, pages e2599
RESTATHOMPSON, IMMUNOL. REV., vol. 161, 1998, pages 95 - 109
SADEJ, MELANOMA RES, vol. 16, 2006, pages 213 - 222
BLAYHOSKIN, CANCER RES., vol. 57, 1997, pages 2602 - 2605
KOBIE ET AL., J. IMMUNOL., vol. 176, 2006, pages 4449 - 4458
CANBOLAT ET AL., BREAST CANCER RES. TREAT., vol. 37, 1996, pages 189 - 193
DURAK ET AL., CANCER LETT., vol. 84, 1994, pages 199 - 202
FLOCKEMANNHERZ, BIOCHIM. BIOPHYS. ACTA, vol. 1076, 1991, pages 273 - 281
BARDOT ET AL., BR. J. CANCER, vol. 70, 1994, pages 212 - 218
HEADRICKWILLIS, BIOCHEM. J., vol. 261, 1989, pages 541 - 550
PROC. NATL. ACAD. SCI., vol. 103, no. 35, 2006, pages 13132 - 13137
AM. J. RESPIR. CRIT. CARE MED., vol. 182, 2010, pages 774 - 783
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 36, 2004, pages 877 - 882
NAT. MED., vol. 16, 2010, pages 1434 - 1438
FASEB J., vol. 22, 2008, pages 2263 - 2272
J. AM. SOC. NEPHROL., vol. 22, no. 5, 2011, pages 890 - 901
PLOS ONE J, vol. 5, no. 2, 2010, pages e9242
J. CLIN. INVEST., vol. 120, no. 6, 2010, pages 1939 - 1949
ULANOVSKAYA ET AL., CHEM. BIOL., vol. 9, no. 5, 2013, pages 300 - 306
YAMADA ET AL., J. NUTR. SCI. VITAMINOL., vol. 56, 2010, pages 83 - 86
EPITOPE MAPPING PROTOCOLS IN METHODS IN MOLECULAR BIOLOGY, vol. 66, 1996
CASELLAS ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
PROC. NATL. ACAD. SCI. U.S.A., vol. 103, no. 11, 2006, pages 4005 - 4010
CURR. OPIN. BIOTECHNOL., vol. 20, no. 6, 2009, pages 685 - 91
CURR. OPIN. IMMUNOL., vol. 20, no. 4, 2008, pages 460 - 470
PROTEIN ENG. DES. SEL., vol. 23, no. 4, 2010, pages 195 - 202
VAUPEL ET AL., CANCER RES., vol. 49, 1989, pages 6449 - 6665
SATOH MIIDA SSHITARA K., EXPERT OPIN. BIOL. THER., vol. 6, no. 11, 2006, pages 1161 - 1173
WEITZHANDLER ET AL., J. PHARMA. SCIENCES, vol. 83, no. 12, 1994, pages 1670 - 1675
SCHENK ET AL., J. CLIN. INVESTIGATION, vol. 108, no. 11, 2001, pages 1687 - 1695
BIGGE ET AL., ANAL. BIOCHEM., vol. 230, no. 2, 1995, pages 229 - 238
BURMEISTER ET AL., NATURE, vol. 372, 1994, pages 336 - 343
CUR. OPIN. IN BIOTECH., vol. 20, no. 6, 2009, pages 685 - 691
IMMUNITY, vol. 23, 2005, pages 503 - 514
RAGHAVAN ET AL., IMMUNITY, vol. 1, 1994, pages 303 - 315
CURR OPIN CHEM BIOL, vol. 14, 2010, pages 529 - 37
LANGONE ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
THORPE ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
WAWRZYNCZAK ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
BOLOGNESI ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE F.BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
HEINRICH ET AL., BIOCHEM. J., vol. 334, 1998, pages 297 - 314
ISHIKAWA ET AL., J. CLIN. EXP. HEMATOPATHOL., vol. 46, no. 2, 2006, pages 55 - 66
CANCER RES., vol. 53, 1993, pages 851 - 856
J. APPL. PHYS., vol. 248, 2003, pages L798 - L800
GERNGROSS, NAT. BIOTECH., vol. 22, 2004, pages 1409 - 1414
LI ET AL., NAT. BIOTECH., vol. 24, 2006, pages 210 - 215
GRAHAM ET AL., J. GEN VIROL., vol. 36, 1977, pages 59
MATHER, BIOL. REPROD., vol. 23, 1980, pages 243 - 251
MATHER ET AL., ANNALS N.Y. ACAD. SCI., vol. 383, 1982, pages 44 - 68
URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
J. IMMUNOL. METHODS., 28 September 2003 (2003-09-28), pages 139 - 55
BMC BIOTECHNOL, vol. 9, 29 January 2009 (2009-01-29), pages 6
PROC NATL ACAD SCI USA., vol. 97, no. 20, 26 September 2000 (2000-09-26), pages 10701 - 5
TOMLINSON ET AL., J. MOL. BIOL., vol. 227, 1992, pages 799 - 817
WILLIAMSWINTER, EUR. J. IMMUNOL., vol. 23, 1993, pages 1456 - 1461
COX ET AL., NAT. GENETICS, vol. 7, 1994, pages 162 - 168
MATSUDA ET AL., J. EXP. MED., vol. 188, 1998, pages 1973 - 1975
KAWASAKI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 1017 - 1028
SCHABLEZACHAU, BIOL. CHEM. HOPPE SEYLER, vol. 374, 1993, pages 1001 - 1022
BRENSING-KUPPERS ET AL., GENE, vol. 191, 1997, pages 173 - 181
KAWASAKI ET AL., GENOME RES, vol. 7, 1997, pages 250 - 261
WU ET AL., J. EXP. MED., vol. 132, 1970, pages 211 - 250
BBRC, vol. 436, no. 3, 2013, pages 543 - 50
GEJIMA ET AL., HUMAN ANTIBODIES, vol. 11, 2002, pages 121 - 129
CARDOSO ET AL., SCAND. J. IMMUNOL., vol. 51, 2000, pages 337 - 344
AL-LAZIKANI ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
GONZALEZ-MUNOZ A ET AL., MABS, 2012
LEE CV ET AL., J MOL BIOL., 2004
KNAPPIK A. ET AL., J MOL BIOL., 2000
TILLER T ET AL., MABS, 2013
BARRETINA J ET AL., NATURE, vol. 483, 2012, pages 603 - 7
REINOSO RF ET AL., DRUG METAB DISPOS, vol. 29, April 2001 (2001-04-01), pages 453 - 9
METHODS MOL. BIOL., vol. 178, 2002, pages 133 - 145
J. APPL. CRYST., vol. 43, 2010, pages 186 - 190
J. APPL. CRYST., vol. 40, 2007, pages 658 - 674
ACTA CRYST, vol. D66, 2010, pages 486 - 501
ACTA CRYST, vol. D67, 2011, pages 293 - 302
METHODS MOL. BIOL., vol. 178, 2002, pages 133 - 145
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
STEVENS A. P. ET AL.: "Quantitative analysis of 5'-deoxy-5'- methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY B, vol. 876, 2008, pages 123 - 128, XP025681507, DOI: 10.1016/j.jchromb.2008.10.038
KATHARINA LIMM, WALLNER SUSANNE, MILENKOVIC VLADIMIR M., WETZEL CHRISTIAN H., BOSSERHOFF ANJA-KATRIN: "The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma", EUROPEAN JOURNAL OF CANCER, vol. 50, no. 15, 30 July 2014 (2014-07-30) - October 2014 (2014-10-01), pages 2714 - 2724, XP055741192
JANICE M REICHERTCLARK J ROSENSWEIGLAURA B FADENMATTHEW C DEWITZ: "Monoclonal antibody successes in the clinic", NAT. BIOTECHNOL., vol. 23, 2005, pages 1073 - 1078, XP002555770, DOI: 10.1038/nbt0905-1073
PAVLOU AKBELSEY MJ.: "The therapeutic antibodies market to 2008", EUR. J. PHARM. BIOPHARM., vol. 59, no. 3, 2005, pages 389 - 396, XP025317626, DOI: 10.1016/j.ejpb.2004.11.007
WEINER LMSURANA RWANG S.: "Monoclonal antibodies: versatile platforms for cancer immunotherapy", NAT. REV. IMMUNOL., vol. 10, no. 5, 2010, pages 317 - 327, XP055217481, DOI: 10.1038/nri2744
LEWIS GDFIGARI IFENDLY BWONG WLCARTER PGORMAN CSHEPARD HM: "Differential responses of human tumor cell lines to anti-pl85HER2 monoclonal antibodies", CANCER IMMUNOL. IMMUNOTHERAPY, vol. 37, 1993, pages 255 - 263, XP002961547, DOI: 10.1007/BF01518520
SATOH MIIDA SSHITARA K.: "Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies", EXPERT OPIN. BIOL. THER., vol. 6, no. 11, 2006, pages 1161 - 1173, XP008078583, DOI: 10.1517/14712598.6.11.1161
DESJARLAIS JRLAZAR GAZHUKOVSKY EACHU SY.: "Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective", DRUG DISCOV. TODAY, vol. 12, 2007, pages 898 - 910, XP022338218, DOI: 10.1016/j.drudis.2007.08.009
ALLEY SCOKELEY NMSENTER PD.: "Antibody-drug conjugates: targeted drug delivery for cancer", CURR. OPIN. CHEM. BIOL., vol. 14, no. 4, 2010, pages 529 - 537, XP055042125, DOI: 10.1016/j.cbpa.2010.06.170
BAEUERLE PAKUFER PBARGOU R.: "BiTE: Teaching antibodies to engage T-cells for cancer therapy", CURR. OPIN. MOL. THER., vol. 11, no. 1, 2009, pages 22 - 30, XP009151509
LUTTERBUESE RRAUM TKISCHEL RHOFFMANN PMANGOLD SRATTEL BFRIEDRICH MTHOMAS OLORENCZEWSKI GRAU D: "T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells", PROC. NATL. ACAD. SCI. U.S.A., vol. 107, no. 28, 2010, pages 12605 - 12610, XP055067703, DOI: 10.1073/pnas.1000976107
RIECHELMANN HSAUTER AGOLZE WHANFT GSCHROEN CHOERMANN KERHARDT TGRONAU S: "Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma", ORAL ONCOL, vol. 44, no. 9, 2008, pages 823 - 829, XP024341160, DOI: 10.1016/j.oraloncology.2007.10.009
TRINH VAHWU WJ.: "Ipilimumab in the treatment of melanoma", EXPERT OPIN. BIOL. THER., 2012
KIM SJPARK YHONG HJ.: "Antibody engineering for the development of therapeutic antibodies", MOL. CELLS., vol. 20, no. 1, 2005, pages 17 - 29
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. U.S.A., vol. 100, no. 11, 2003, pages 6353 - 6357
CO, M. S. ET AL., J. IMMUNOL., vol. 152, no. 10, 1994, pages 2968 - 2976
NAT. MED., vol. 13, 2007, pages 851 - 856
PORTOLANO ET AL., J. IMMUNOL., vol. 150, 1993, pages 880 - 887
CLARKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
CHOTHIA AND LESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
BIRD ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
PLUECKTHUN AND SKERRA, METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
HUSTON ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, no. 23, 1988, pages 8998 - 9002
HUDSON ET AL., J. IMMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
BETTER, M.HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E.WALKER, B. W., BIOTECHNOL, vol. 9, 1991, pages 132 - 137
C VINCKE ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, pages 3273 - 3284
METHODS IN MOLECULAR BIOLOGY, vol. 911, 2012, pages 65 - 78
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1764, no. 8, 2006, pages 1307 - 1319
JOURNAL OF APPLIED MICROBIOLOGY, vol. 117, no. 2, 2014, pages 528 - 536
JOURNAL OF BIOMOLECULAR SCREENING, vol. 21, no. 1, 2016, pages 35 - 43
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 24, 2016, pages 12641 - 12657
AIDS, vol. 30, no. 11, 2016, pages 1691 - 1701
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
J. IMMUNOL. METHODS, vol. 35, no. 1-2, 1980, pages 1 - 21
J. EXP. MED., vol. 148, no. 1, 1978, pages 313 - 323
NATURE, vol. 277, no. 5692, 1979, pages 131 - 133
KOHLERMILSTEIN ET AL., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
CURRENT PROTOCOLS IN PROTEIN SCIENCE, May 2001 (2001-05-01)
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CONRATH ET AL., J. BIOL. CHEM., vol. 276, no. 10, 2001, pages 7346 - 7350
MUYLDERMANS, REV. MOL. BIOTECH., vol. 74, 2001, pages 277 - 302
MILSTEIN ET AL., NATURE, vol. 305, 1983, pages 537 - 540
HOLLIGER ET AL., PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
MERCHANT ET AL., NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681
STEVENS ET AL., J CHROMATOGR A., vol. 1217, no. 19, 7 May 2010 (2010-05-07), pages 3282 - 8
EVA GOTTFRIEDKATRIN PETERMARINA P. KREUTZ, FROM MOLECULAR TO MODULAR TUMOR THERAPY, vol. 3, no. 2, 2010, pages 111 - 132
DHANASEKARAN ET AL., NATURE, vol. 412, 2001, pages 822 - 826
LAPOINTE ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 101, 2004, pages 811 - 816
PEROU ET AL., NATURE, vol. 406, 2000, pages 747 - 752
AHRAM ET AL., MOL. CARCINOG., vol. 33, 2002, pages 9 - 15
HOOD ET AL., MOL. CELL. PROTEOMICS, vol. 4, 2005, pages 1741 - 1753
BRINDLE ET AL., J. MOL. RECOGNIT., vol. 10, 1997, pages 182 - 187
GATESSWEELEY, CLIN. CHEM., vol. 24, 1978, pages 1663 - 1673
DANGSEMENZA, TRENDS BIOCHEM. SCI., vol. 24, 1999, pages 68 - 72
VIZAN ET AL., CANCER RES., vol. 65, 2005, pages 5512 - 5515
LAWTON ET AL., PHARMACOGENOMICS, vol. 9, 2008, pages 383
DESMOULIN F ET AL., DRUG METAB DISPOS, 2002
DUAN JX ET AL., J MED CHEM., 2008
CHRISTOFK ET AL., NATURE, vol. 452, 2008, pages 230 - 233
FANTIN ET AL., CANCER CELL, vol. 9, 2006, pages 425 - 434
TERESA ET AL., MOL. CANCER, vol. 8, 2009, pages 41 - 59
NATURE IMMUNOLOGY, vol. 9, 2008, pages 1261 - 1269
MAZUREKEIGENBRODT, ANTICANCER RES, vol. 23, 2003, pages 1149 - 1154
MAZUREK ET AL., J. CELL. PHYSIOL., vol. 181, 1999, pages 136 - 146
DROGE, IMMUNOBIOLOGY, vol. 174, 1987, pages 473 - 479
UYTTENHOVE ET AL., NAT. MED., vol. 9, 2003, pages 1269 - 127
LOB ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 58, 2009, pages 153 - 157
OPITZ ET AL., NATURE, vol. 478, no. 7368, 2011, pages 197 - 203
J. IMMUNOL., vol. 181, 2008, pages 5396 - 5404
YU ET AL., J. IMMUNOL., vol. 190, 2013, pages 3783 - 3797
FRUMENTO ET AL., J. EXP. MED., vol. 196, 2002, pages 459 - 468
WARNERMITCHELL, FASEB J, vol. 18, 2004, pages 790 - 804
SHENG ET AL., CANCER RES., vol. 58, 1998, pages 362 - 366
DENKERT ET AL., CLIN. BREAST CANCER, vol. 4, 2004, pages 428 - 433
DENKER ET AL., MOD. PATHOL., vol. 19, 2006, pages 1261 - 1269
CURR. MED. CHEM., vol. 18, 2011, pages 5217 - 5223
NAT. REV. CANCER, vol. 12, no. 11, 2012, pages 782 - 792
J. LAB. CLIN. MED., vol. 122, 1993, pages 518 - 523
EUR. J. CLIN. PHARMACOL., vol. 46, 1994, pages 3 - 7
CLIN. EXP. RHEUMATOL., vol. 17, 1999, pages 151 - 160
AM. J. VET. RES., vol. 65, 2004, pages 1269 - 1275
PLOS ONE, vol. 3, 2008, pages e2599
RESTATHOMPSON, IMMUNOL. REV., vol. 161, 1998, pages 95 - 109
SADEJ, MELANOMA RES, vol. 16, 2006, pages 213 - 222
BLAYHOSKIN, CANCER RES., vol. 57, 1997, pages 2602 - 2605
KOBIE ET AL., J. IMMUNOL., vol. 176, 2006, pages 4449 - 4458
CANBOLAT ET AL., BREAST CANCER RES. TREAT., vol. 37, 1996, pages 189 - 193
DURAK ET AL., CANCER LETT., vol. 84, 1994, pages 199 - 202
FLOCKEMANNHERZ, BIOCHIM. BIOPHYS. ACTA, vol. 1076, 1991, pages 273 - 281
BARDOT ET AL., BR. J. CANCER, vol. 70, 1994, pages 212 - 218
HEADRICKWILLIS, BIOCHEM. J., vol. 261, 1989, pages 541 - 550
PROC. NATL. ACAD. SCI., vol. 103, no. 35, 2006, pages 13132 - 13137
AM. J. RESPIR. CRIT. CARE MED., vol. 182, 2010, pages 774 - 783
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 36, 2004, pages 877 - 882
NAT. MED., vol. 16, 2010, pages 1434 - 1438
FASEB J., vol. 22, 2008, pages 2263 - 2272
J. AM. SOC. NEPHROL., vol. 22, no. 5, 2011, pages 890 - 901
PLOS ONE J, vol. 5, no. 2, 2010, pages e9242
J. CLIN. INVEST., vol. 120, no. 6, 2010, pages 1939 - 1949
ULANOVSKAYA ET AL., CHEM. BIOL., vol. 9, no. 5, 2013, pages 300 - 306
YAMADA ET AL., J. NUTR. SCI. VITAMINOL., vol. 56, 2010, pages 83 - 86
EPITOPE MAPPING PROTOCOLS IN METHODS IN MOLECULAR BIOLOGY, vol. 66, 1996
CASELLAS ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
PROC. NATL. ACAD. SCI. U.S.A., vol. 103, no. 11, 2006, pages 4005 - 4010
CURR. OPIN. BIOTECHNOL., vol. 20, no. 6, 2009, pages 685 - 91
CURR. OPIN. IMMUNOL., vol. 20, no. 4, 2008, pages 460 - 470
PROTEIN ENG. DES. SEL., vol. 23, no. 4, 2010, pages 195 - 202
VAUPEL ET AL., CANCER RES., vol. 49, 1989, pages 6449 - 6665
SATOH MIIDA SSHITARA K., EXPERT OPIN. BIOL. THER., vol. 6, no. 11, 2006, pages 1161 - 1173
WEITZHANDLER ET AL., J. PHARMA. SCIENCES, vol. 83, no. 12, 1994, pages 1670 - 1675
SCHENK ET AL., J. CLIN. INVESTIGATION, vol. 108, no. 11, 2001, pages 1687 - 1695
BIGGE ET AL., ANAL. BIOCHEM., vol. 230, no. 2, 1995, pages 229 - 238
BURMEISTER ET AL., NATURE, vol. 372, 1994, pages 336 - 343
CUR. OPIN. IN BIOTECH., vol. 20, no. 6, 2009, pages 685 - 691
IMMUNITY, vol. 23, 2005, pages 503 - 514
RAGHAVAN ET AL., IMMUNITY, vol. 1, 1994, pages 303 - 315
CURR OPIN CHEM BIOL, vol. 14, 2010, pages 529 - 37
LANGONE ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
THORPE ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
WAWRZYNCZAK ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
BOLOGNESI ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE F.BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
HEINRICH ET AL., BIOCHEM. J., vol. 334, 1998, pages 297 - 314
ISHIKAWA ET AL., J. CLIN. EXP. HEMATOPATHOL., vol. 46, no. 2, 2006, pages 55 - 66
CANCER RES., vol. 53, 1993, pages 851 - 856
J. APPL. PHYS., vol. 248, 2003, pages L798 - L800
GERNGROSS, NAT. BIOTECH., vol. 22, 2004, pages 1409 - 1414
LI ET AL., NAT. BIOTECH., vol. 24, 2006, pages 210 - 215
GRAHAM ET AL., J. GEN VIROL., vol. 36, 1977, pages 59
MATHER, BIOL. REPROD., vol. 23, 1980, pages 243 - 251
MATHER ET AL., ANNALS N.Y. ACAD. SCI., vol. 383, 1982, pages 44 - 68
URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
J. IMMUNOL. METHODS., 28 September 2003 (2003-09-28), pages 139 - 55
BMC BIOTECHNOL, vol. 9, 29 January 2009 (2009-01-29), pages 6
PROC NATL ACAD SCI USA., vol. 97, no. 20, 26 September 2000 (2000-09-26), pages 10701 - 5
TOMLINSON ET AL., J. MOL. BIOL., vol. 227, 1992, pages 799 - 817
WILLIAMSWINTER, EUR. J. IMMUNOL., vol. 23, 1993, pages 1456 - 1461
COX ET AL., NAT. GENETICS, vol. 7, 1994, pages 162 - 168
MATSUDA ET AL., J. EXP. MED., vol. 188, 1998, pages 1973 - 1975
KAWASAKI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 1017 - 1028
SCHABLEZACHAU, BIOL. CHEM. HOPPE SEYLER, vol. 374, 1993, pages 1001 - 1022
BRENSING-KUPPERS ET AL., GENE, vol. 191, 1997, pages 173 - 181
KAWASAKI ET AL., GENOME RES, vol. 7, 1997, pages 250 - 261
WU ET AL., J. EXP. MED., vol. 132, 1970, pages 211 - 250
BBRC, vol. 436, no. 3, 2013, pages 543 - 50
GEJIMA ET AL., HUMAN ANTIBODIES, vol. 11, 2002, pages 121 - 129
CARDOSO ET AL., SCAND. J. IMMUNOL., vol. 51, 2000, pages 337 - 344
AL-LAZIKANI ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
GONZALEZ-MUNOZ A ET AL., MABS, 2012
LEE CV ET AL., J MOL BIOL., 2004
KNAPPIK A. ET AL., J MOL BIOL., 2000
TILLER T ET AL., MABS, 2013
BARRETINA J ET AL., NATURE, vol. 483, 2012, pages 603 - 7
REINOSO RF ET AL., DRUG METAB DISPOS, vol. 29, April 2001 (2001-04-01), pages 453 - 9
METHODS MOL. BIOL., vol. 178, 2002, pages 133 - 145
J. APPL. CRYST., vol. 43, 2010, pages 186 - 190
J. APPL. CRYST., vol. 40, 2007, pages 658 - 674
ACTA CRYST, vol. D66, 2010, pages 486 - 501
ACTA CRYST, vol. D67, 2011, pages 293 - 302
METHODS MOL. BIOL., vol. 178, 2002, pages 133 - 145
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Download PDF:
Previous Patent: FITTING STRUCTURE FOR UPPER CAP AND DIVISION BAR
Next Patent: MODIFIED ADENOVIRUS AND MEDICINE COMPRISING SAME
Next Patent: MODIFIED ADENOVIRUS AND MEDICINE COMPRISING SAME