Title:
ANTIGEN BINDING PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/161454
Kind Code:
A1
Abstract:
An antigen binding protein and the use thereof. The antigen binding protein can compete with pembrolizumab for binding to the same or overlapping PD-1 epitope. The antigen binding protein can effectively inhibit the binding of human PD-L1 to human PD-1 with an EC50 of approximately 2 μg/mL or less.
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Inventors:
CAO GUOQING (CN)
ZHU LIYUAN (CN)
SHI JUNWEI (CN)
ZHU LIYUAN (CN)
SHI JUNWEI (CN)
Application Number:
PCT/CN2022/074550
Publication Date:
August 04, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
MINGHUI PHARMACEUTICAL HANGZHOU LTD (CN)
MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN)
MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN)
International Classes:
C12N15/13; A61K39/395; A61P31/00; C07K16/18
Domestic Patent References:
| WO2020185722A2 | 2020-09-17 | |||
| WO2009114335A2 | 2009-09-17 | |||
| WO2008156712A1 | 2008-12-24 |
Foreign References:
| CN106163547A | 2016-11-23 | |||
| CN110734493A | 2020-01-31 | |||
| CN108473977A | 2018-08-31 |
Other References:
ZHANG YUE-FAN, SHUO-WEN WANG, GUO-RONG FAN: "Comprehensive evaluation of nivolumab and pembrolizumab", ZHONG NAN YAO XUE, CN, vol. 17, no. 8, 31 August 2019 (2019-08-31), CN , pages 1274 - 1279, XP055954840, ISSN: 1672-2981, DOI: 10.7539/j.issn.1672-2981.2019.08.021
GERRY KWOK, ET AL.: "Pembrolizumab (Keytruda)", HUMAN VACCINES & IMMUNOTHERAPEUTICS, TAYLOR & FRANCIS, US, vol. 12, no. 11, 4 June 2016 (2016-06-04), US , pages 2777 - 2789, XP055609923, ISSN: 2164-5515, DOI: 10.1080/21645515.2016.1199310
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CLACKSON, NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., MOL. BIOL., vol. 222, 1991, pages 581 - 597
ISHIDA ET AL., EMBO J, vol. 11, 1992, pages 3887 - 3895
AGATA ET AL., INT. IMMUNOLOGY, vol. 8, 1996, pages 765 - 772
CHINAI ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 36, 2015, pages 587 - 595
"UniProt", Database accession no. Q 15116
"NCBI", Database accession no. NP001254653
SAMBROOK: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
GERRY KWOK, ET AL.: "Pembrolizumab (Keytruda)", HUMAN VACCINES & IMMUNOTHERAPEUTICS, TAYLOR & FRANCIS, US, vol. 12, no. 11, 4 June 2016 (2016-06-04), US , pages 2777 - 2789, XP055609923, ISSN: 2164-5515, DOI: 10.1080/21645515.2016.1199310
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA, NATURE, vol. 342, 1989, pages 877 - 883
PADLAN, FASEB J, vol. 9, 1995, pages 133 - 139
MACCALLUM, J MOL BIOL, vol. 262, no. 5, 1996, pages 732 - 45
CLACKSON, NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., MOL. BIOL., vol. 222, 1991, pages 581 - 597
ISHIDA ET AL., EMBO J, vol. 11, 1992, pages 3887 - 3895
AGATA ET AL., INT. IMMUNOLOGY, vol. 8, 1996, pages 765 - 772
CHINAI ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 36, 2015, pages 587 - 595
"UniProt", Database accession no. Q 15116
"NCBI", Database accession no. NP001254653
SAMBROOK: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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