Title:
ANTIGEN PROTEIN AND NUCLEIC ACID CODING FOR SAID PROTEIN
Document Type and Number:
WIPO Patent Application WO/1999/016881
Kind Code:
A1
Abstract:
A novel antigen protein which is useful for treatment and diagnosis of diseases derived from fungi including $i(Candida albicans); and a nucleic acid coding for the antigen protein. The antigen protein is characterized by being recognized by an antiserum derived from a $i(Candida albicans) infection resistant mammal and the nucleic acid codes for an antigen protein recognized by an antiserum derived from a $i(Candida albicans) infection resistant mammal.
Inventors:
TAKESAKO KAZUTOH (JP)
MIZUTANI SHIGETOSHI (JP)
ENDO MASAHIRO (JP)
OGAWA JUNKO (JP)
OKADO TAKASHI (JP)
KATO IKUNOSHIN (JP)
MIZUTANI SHIGETOSHI (JP)
ENDO MASAHIRO (JP)
OGAWA JUNKO (JP)
OKADO TAKASHI (JP)
KATO IKUNOSHIN (JP)
Application Number:
PCT/JP1998/004326
Publication Date:
April 08, 1999
Filing Date:
September 28, 1998
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
TAKESAKO KAZUTOH (JP)
MIZUTANI SHIGETOSHI (JP)
ENDO MASAHIRO (JP)
OGAWA JUNKO (JP)
OKADO TAKASHI (JP)
KATO IKUNOSHIN (JP)
TAKESAKO KAZUTOH (JP)
MIZUTANI SHIGETOSHI (JP)
ENDO MASAHIRO (JP)
OGAWA JUNKO (JP)
OKADO TAKASHI (JP)
KATO IKUNOSHIN (JP)
International Classes:
G01N33/50; A61K38/00; A61K39/00; A61K49/00; A61P13/02; A61P15/00; A61P31/04; C07K14/40; C07K16/14; C12N5/10; C12N15/09; C12N15/31; C12Q1/68; G01N33/53; G01N33/569; (IPC1-7): C12N15/31; C07K14/40
Domestic Patent References:
| WO1996036707A1 | 1996-11-21 |
Other References:
EROLES P, ET AL.: "CLONING OF A DNA FRAGMENT ENCODING PART OF A 70-KDA HEAT SHOCK PROTEIN OF CANDIDA ALBICANS", FEMS MICROBIOLOGY LETTERS, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 128, 1 January 1995 (1995-01-01), GB, pages 95 - 100, XP002917384, ISSN: 0378-1097, DOI: 10.1016/0378-1097(95)00089-N
MANEU V, ET AL.: "MOLECULAR CLONING OF A CANDIDA ALBICANS GENE (SSB1) CODING FOR A PROTEIN RELATED TO THE HSP70 FAMILY", YEAST, JOHN WILEY & SONS LTD., GB, vol. 13, 1 January 1997 (1997-01-01), GB, pages 677 - 681, XP002917385, ISSN: 0749-503X, DOI: 10.1002/(SICI)1097-0061(19970615)13:7<677::AID-YEA131>3.3.CO;2-Y
GIL-NAVARRO I, ET AL.: "THE GLYCOLYTIC ENZYME GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE OF CANDIDA ALBICANS IS A SURFACE ANTIGEN", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 179, no. 16, 1 January 1997 (1997-01-01), US, pages 4992 - 4999, XP002917386, ISSN: 0021-9193
GOMEZ M J, ET AL.: "PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF A 65-KILODALTON MANNOPROTEIN (MP65), A MAIN TARGET OF ANTI-CANDIDA CELL-MEDIATED IMMUNE RESPONSES IN HUMANS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 64, no. 07, 1 July 1996 (1996-07-01), US, pages 2577 - 2584, XP002917387, ISSN: 0019-9567
SEPULVEDA P, ET AL.: "EVIDENCE FOR THE PRESENCE OF COLLAGENOUS DOMAINS IN CANDIDA ALBICANS CELL SURFACE PROTEINS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 63, no. 06, 1 June 1995 (1995-06-01), US, pages 2173 - 2179, XP002917388, ISSN: 0019-9567
TRINEL P-A, ET AL.: "ISOLATION AND PRELIMINARY CHARACTERIZATION OF THE 14- TO 18- KILODALTON CANDIDA ALBICANS ANTIGEN AS A PHOSPHOLIPOMANNAN CONTAINING BETA-1,2-LINKED OLIGOMANNOSIDES", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 61, no. 10, 1 October 1993 (1993-10-01), US, pages 4398 - 4408, XP002918168, ISSN: 0019-9567
SHEN H-D, ET AL.: "CHARACTERIZATION OF A MONOCLONAL ANTIBODY (RJ5) AGAINST THE IMMUNODOMINANT 41-KD ANTIGEN OF CANDIDA ALBICANS", INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, BASEL, CH, vol. 96, no. 02, 1 January 1991 (1991-01-01), CH, pages 142 - 148, XP002917389, ISSN: 0020-5915
SHEN H-D, ET AL.: "THE 40-KILODALTON ALLERGEN OF CANDIDA ALBICANS IS AN ALCOHOL DEHYDROGENASE: MOLECULAR CLONING AND IMMUNOLOGICAL ANALYSIS USING MONOCLONAL ANTIBODIES", CLINICAL & EXPERIMENTAL ALLERGY : JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, WILEY INTERSCIENCE, UK, vol. 21, no. 06, 1 January 1991 (1991-01-01), UK, pages 675 - 682, XP002917390, ISSN: 0954-7894
See also references of EP 1026245A4
MANEU V, ET AL.: "MOLECULAR CLONING OF A CANDIDA ALBICANS GENE (SSB1) CODING FOR A PROTEIN RELATED TO THE HSP70 FAMILY", YEAST, JOHN WILEY & SONS LTD., GB, vol. 13, 1 January 1997 (1997-01-01), GB, pages 677 - 681, XP002917385, ISSN: 0749-503X, DOI: 10.1002/(SICI)1097-0061(19970615)13:7<677::AID-YEA131>3.3.CO;2-Y
GIL-NAVARRO I, ET AL.: "THE GLYCOLYTIC ENZYME GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE OF CANDIDA ALBICANS IS A SURFACE ANTIGEN", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 179, no. 16, 1 January 1997 (1997-01-01), US, pages 4992 - 4999, XP002917386, ISSN: 0021-9193
GOMEZ M J, ET AL.: "PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF A 65-KILODALTON MANNOPROTEIN (MP65), A MAIN TARGET OF ANTI-CANDIDA CELL-MEDIATED IMMUNE RESPONSES IN HUMANS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 64, no. 07, 1 July 1996 (1996-07-01), US, pages 2577 - 2584, XP002917387, ISSN: 0019-9567
SEPULVEDA P, ET AL.: "EVIDENCE FOR THE PRESENCE OF COLLAGENOUS DOMAINS IN CANDIDA ALBICANS CELL SURFACE PROTEINS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 63, no. 06, 1 June 1995 (1995-06-01), US, pages 2173 - 2179, XP002917388, ISSN: 0019-9567
TRINEL P-A, ET AL.: "ISOLATION AND PRELIMINARY CHARACTERIZATION OF THE 14- TO 18- KILODALTON CANDIDA ALBICANS ANTIGEN AS A PHOSPHOLIPOMANNAN CONTAINING BETA-1,2-LINKED OLIGOMANNOSIDES", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 61, no. 10, 1 October 1993 (1993-10-01), US, pages 4398 - 4408, XP002918168, ISSN: 0019-9567
SHEN H-D, ET AL.: "CHARACTERIZATION OF A MONOCLONAL ANTIBODY (RJ5) AGAINST THE IMMUNODOMINANT 41-KD ANTIGEN OF CANDIDA ALBICANS", INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, BASEL, CH, vol. 96, no. 02, 1 January 1991 (1991-01-01), CH, pages 142 - 148, XP002917389, ISSN: 0020-5915
SHEN H-D, ET AL.: "THE 40-KILODALTON ALLERGEN OF CANDIDA ALBICANS IS AN ALCOHOL DEHYDROGENASE: MOLECULAR CLONING AND IMMUNOLOGICAL ANALYSIS USING MONOCLONAL ANTIBODIES", CLINICAL & EXPERIMENTAL ALLERGY : JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, WILEY INTERSCIENCE, UK, vol. 21, no. 06, 1 January 1991 (1991-01-01), UK, pages 675 - 682, XP002917390, ISSN: 0954-7894
See also references of EP 1026245A4
Attorney, Agent or Firm:
Hosoda, Yoshinori (Tanimachi 2-chome Chuo-ku, Osaka-shi Osaka, JP)
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